(Q36159130)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

cAMP and Epac in the regulation of tissue fibrosis (English)

1 reference

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20 January 2020

2

1 reference

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20 January 2020

author name string

Paul A Insel

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Utako Yokoyama

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Silvia Romano

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Hongruo Yun

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Loren Brown

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Aaron Snead

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

David Lu

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Nakon Aroonsakool

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

language of work or name

English

0 references

publication date

1 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Pharmacology

20 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

volume

166

1 reference

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20 January 2020

issue

2

1 reference

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20 January 2020

page(s)

447-456

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

Circulating fibrocytes--biology and mechanisms in wound healing and scar formation

20 January 2020

cites work

1 reference

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Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

2 October 2017

1 reference

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Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts

2 October 2017

1 reference

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Pericytes: developmental, physiological, and pathological perspectives, problems, and promises

2 October 2017

1 reference

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Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts by reorganizing protein kinase A signaling

2 October 2017

1 reference

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Integrating mechanisms of pulmonary fibrosis

2 October 2017

1 reference

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Mechanisms of resolution of inflammation: a focus on cardiovascular disease

2 October 2017

1 reference

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Anti-fibrogenic strategies and the regression of fibrosis

2 October 2017

1 reference

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GPCR expression in tissues and cells: are the optimal receptors being used as drug targets?

2 October 2017

1 reference

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A perspective on cancer cell metastasis

2 October 2017

1 reference

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Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition

2 October 2017

1 reference

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Mechanisms of fibrosis: the role of the pericyte

2 October 2017

1 reference

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Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications

2 October 2017

1 reference

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Matrix control of scarring.

2 October 2017

1 reference

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Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger

2 October 2017

1 reference

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Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

2 October 2017

1 reference

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G protein-coupled receptor kinase-2 is a novel regulator of collagen synthesis in adult human cardiac fibroblasts

2 October 2017

1 reference

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Fibroblasts and myofibroblasts in renal fibrosis

2 October 2017

1 reference

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The role of cell plasticity in progression and reversal of renal fibrosis

2 October 2017

1 reference

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Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

2 October 2017

1 reference

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Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.

2 October 2017

1 reference

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FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition

2 October 2017

1 reference

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Smaddening complexity: the role of Smad3 in epithelial-myofibroblast transition

2 October 2017

1 reference

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Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Update on the pathophysiology of liver fibrosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

The origin of fibroblasts and mechanism of cardiac fibrosis

2 October 2017

1 reference

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Experimental therapies in hypertrophic cardiomyopathy

2 October 2017

1 reference

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Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation

2 October 2017

1 reference

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The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice

2 October 2017

1 reference

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Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis.

2 October 2017

1 reference

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The role of inflammatory and fibrogenic pathways in heart failure associated with aging.

2 October 2017

1 reference

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Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3

2 October 2017

1 reference

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Epac: defining a new mechanism for cAMP action

2 October 2017

1 reference

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Pirfenidone: an anti-fibrotic therapy for progressive kidney disease

2 October 2017

1 reference

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Reversibility of liver fibrosis.

2 October 2017

1 reference

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Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis

2 October 2017

1 reference

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Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

The myofibroblast: paradigm for a mechanically active cell

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Prostaglandin E2 differentially regulates contraction and structural reorganization of anchored collagen gels by human adult and fetal dermal fibroblasts.

2 October 2017

1 reference

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Effect of cAMP on TGFbeta1-induced corneal keratocyte-myofibroblast transformation

2 October 2017

1 reference

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Regulation of transforming growth factor beta-induced responses by protein kinase A in pancreatic acinar cells.

2 October 2017

1 reference

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The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Prostaglandin E2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac-1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts.

2 October 2017

1 reference

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Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

2 October 2017

1 reference

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Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

2 October 2017

1 reference

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p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway

2 October 2017

1 reference

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Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase

2 October 2017

1 reference

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Inflammation-associated remodelling and fibrosis in the lung - a process and an end point

2 October 2017

1 reference

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Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: role of inhibiting TGF-beta-induced epithelial-to-mesenchymal transition

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Epac proteins: multi-purpose cAMP targets

2 October 2017

1 reference

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cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Prostaglandin D2 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in MDCK cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Prostaglandin E2 is a potent inhibitor of epithelial-to-mesenchymal transition: interaction with hepatocyte growth factor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Fibrotic lung fibroblasts show blunted inhibition by cAMP due to deficient cAMP response element-binding protein phosphorylation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts.

2 October 2017

1 reference

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Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging

2 October 2017

1 reference

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Role of prostaglandin E(2) EP receptors and cAMP in the expression of connective tissue growth factor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Inhibition of TGF-beta-stimulated CTGF gene expression and anchorage-independent growth by cAMP identifies a CTGF-dependent restriction point in the cell cycle.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

alpha 1- and beta 2-adrenergic receptor expression in the Madin-Darby canine kidney epithelial cell line

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Cyclic AMP-Dependent Protein Kinase: Pivotal Role in Regulation of Enzyme Induction and Growth

2 October 2017

1 reference

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Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure

2 October 2017

1 reference

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Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block.

2 July 2018

1 reference

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Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis

2 July 2018

1 reference

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Renal alpha 1-adrenergic receptor subtypes: MDCK-D1 cells, but not rat cortical membranes possess a single population of receptors.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA.

2 July 2018

1 reference

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Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome.

23 September 2018

1 reference

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Prostacyclin receptor suppresses cardiac fibrosis: role of CREB phosphorylation

23 September 2018

1 reference

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Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition

23 September 2018

1 reference

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Procaterol inhibits lung fibroblast migration

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Inhibition of TGF-beta induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Differential regulation of free-floating collagen gel contraction by human fetal and adult dermal fibroblasts in response to prostaglandin E2 mediated by an EP2/cAMP-dependent mechanism.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)-beta1-induced collagen synthesis.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Prostaglandin E2 differentially modulates human fetal and adult dermal fibroblast migration and contraction: implication for wound healing.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Inhibitory control of TGF-beta1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Cyclic adenosine 3',5'-monophosphate-elevating agents inhibit transforming growth factor-beta-induced SMAD3/4-dependent transcription via a protein kinase A-dependent mechanism.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3417479

Elevation of intracellular cyclic AMP inhibits NF-kappaB-mediated thymosin beta4 expression in melanoma cells

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22233238

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1476-5381.2012.01847.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

22233238

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22233238%20AND%20SRC:MED&resulttype=core&format=json