(Q36170226)

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Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

based on heuristic

inferred from title

Lutzomyia longipalpis

1 reference

based on heuristic

inferred from title

Anderson Sa-Nunes

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

José M. Ribeiro

9

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Jesus G Valenzuela

11

object named as

Jesus G Valenzuela

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

author name string

Nicolas Collin

1

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7 February 2020

Teresa C F Assumpção

2

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7 February 2020

Daniella M Mizurini

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Dana C Gilmore

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Angélica Dutra-Oliveira

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Michalis Kotsyfakis

6

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7 February 2020

Clarissa Teixeira

8

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Robson Q Monteiro

10

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Ivo M B Francischetti

12

1 reference

Europe PubMed Central

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7 February 2020

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publication date

12 July 2012

1 reference

Europe PubMed Central

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7 February 2020

Arteriosclerosis, Thrombosis, and Vascular Biology

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

32

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

2185-2198

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Simukunin from the salivary glands of the black fly Simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Tissue factor pathway inhibitor: structure-function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Protease-activated receptor 2 signaling in inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Blood coagulation factor Xa as an emerging drug target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Regulation of proteases by protein inhibitors of the serpin superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Complex assemblies of factors IX and X regulate the initiation, maintenance, and shutdown of blood coagulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Dipetalodipin, a novel multifunctional salivary lipocalin that inhibits platelet aggregation, vasoconstriction, and angiogenesis through unique binding specificity for TXA2, PGF2alpha, and 15(S)-HETE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Platelet aggregation inhibitors from hematophagous animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Evidence for tissue factor phosphorylation and its correlation with protease-activated receptor expression and the prognosis of primary breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Analysis of salivary transcripts and antigens of the sand fly Phlebotomus arabicus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Proteinase-activated receptor-2 in the skin: receptor expression, activation and function during health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Active and exo-site inhibition of human factor Xa: structure of des-Gla factor Xa inhibited by NAP5, a potent nematode anticoagulant protein from Ancylostoma caninum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

The immunomodulatory factors of arthropod saliva and the potential for these factors to serve as vaccine targets to prevent pathogen transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Protease-activated receptors in hemostasis, thrombosis and vascular biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

The many faces of protease-protein inhibitor interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Exosite-driven substrate specificity and function in coagulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Protease-activated receptor 2: activation, signalling and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

A novel family of anticoagulants from the saliva of Ixodes scapularis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Role of arthropod saliva in blood feeding: sialome and post-sialome perspectives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Direct measurement of protein binding energetics by isothermal titration calorimetry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

The salivary apyrase of the blood-sucking sand fly Phlebotomus papatasi belongs to the novel Cimex family of apyrases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Delayed onset of inflammation in protease-activated receptor-2-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly Lutzomyia longipalpis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Unexpected binding mode of tick anticoagulant peptide complexed to bovine factor Xa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Isolation and characterization of the gene encoding a novel factor Xa-directed anticoagulant from the yellow fever mosquito, Aedes aegypti

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

X-ray structure of antistasin at 1.9 A resolution and its modelled complex with blood coagulation factor Xa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Ancylostoma caninum anticoagulant peptide: a hookworm-derived inhibitor of human coagulation factor Xa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

1 October 2017

Ixolaris: a factor Xa heparin-binding exosite inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

2 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

2 July 2018

17 The kinetics of reversible tight-binding inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

2 July 2018

Molecular diversity of anticoagulants from haematophagous animals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

23 September 2018

Protein Z-dependent regulation of coagulation.

1 reference

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23 September 2018

Anophelin: kinetics and mechanism of thrombin inhibition

1 reference

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23 September 2018

Triplatin, a platelet aggregation inhibitor from the salivary gland of the triatomine vector of Chagas disease, binds to TXA(2) but does not interact with glycoprotein PVI

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

21 October 2018

Antagonism of Protease-Activated Receptor 2 Protects against Experimental Colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421056

5 December 2018

Antistasin, a leech-derived inhibitor of factor Xa. Kinetic analysis of enzyme inhibition and identification of the reactive site

1 reference

https://pubmed.ncbi.nlm.nih.gov/22796577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa

1 reference

https://pubmed.ncbi.nlm.nih.gov/22796577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heparin chain-length dependence of factor Xa inhibition by antithrombin in plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22796577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Towards a standardization of the murine ferric chloride-induced carotid arterial thrombosis model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22796577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/ATVBAHA.112.253906

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22796577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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