(Q36174039)

12 August 2017

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title

Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand? (English)

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12 August 2017

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Jeffrey M Peters

1

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12 August 2017

Connie Cheung

series ordinal

2

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12 August 2017

Frank J Gonzalez

series ordinal

3

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12 August 2017

language of work or name

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23 June 2005

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Journal of Molecular Medicine

12 August 2017

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12 August 2017

83

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12 August 2017

774-785

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12 August 2017

10

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https://scigraph.springernature.com/pub.10.1007/s00109-005-0678-9

12 August 2017

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cites work

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12 December 2020

Activation of PPARgamma coactivator-1 through transcription factor docking

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12 December 2020

Peroxisome proliferator-activated receptor alpha target genes

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12 December 2020

Age and organ difference in amount and distribution of autofluorescent granules in rats.

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12 December 2020

Peroxisome proliferators do not increase DNA synthesis in purified rat hepatocytes

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12 December 2020

Relationship between morphological changes and lipid-lowering action of p-chlorphenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man

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12 December 2020

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

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12 December 2020

Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding.

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12 December 2020

Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys

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12 December 2020

Contrasting hepatocytic peroxisome proliferation, lipofuscin accumulation and cell turnover for the hepatocarcinogens Wy-14,643 and clofibric acid

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12 December 2020

Induction of fatty acid beta-oxidation and peroxisome proliferation in the liver of rhesus monkeys by DL-040, a new hypolipidemic agent

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12 December 2020

Induction of replicative DNA synthesis and PPAR alpha-dependent gene transcription by Wy-14 643 in primary rat hepatocyte and non-parenchymal cell co-cultures.

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12 December 2020

Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism.

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12 December 2020

Species differences in the effects of bezafibrate, a hypolipidemic agent, on hepatic peroxisome-associated enzymes

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12 December 2020

Species differences in response to diethylhexylphthalate: suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression

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12 December 2020

Effects of di-isononyl phthalate (DINP) on peroxisomal markers in the marmoset-DINP is not a peroxisome proliferator

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12 December 2020

The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants.

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12 December 2020

Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis

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12 December 2020

Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation

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12 December 2020

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

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12 December 2020

Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis

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12 December 2020

Molecular scanning of the human PPARa gene: association of the L162v mutation with hyperapobetalipoproteinemia.

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12 December 2020

Peroxisome proliferator activated receptor-alpha expression in human liver.

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12 December 2020

Consensus for the use of fibrates in the treatment of dyslipoproteinemia and coronary heart disease. Fibrate Consensus Group

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12 December 2020

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

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12 December 2020

Identification of peroxisomal targeting signals located at the carboxy terminus of four peroxisomal proteins

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12 December 2020

The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs.

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12 December 2020

Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients

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12 December 2020

Expression of PPAR(alpha) in human hepatocytes and activation by trichloroacetate and dichloroacetate

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12 December 2020

Recent advances in peroxisome proliferator-activated receptor science

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12 December 2020

Hepatocellular proliferation in response to a peroxisome proliferator does not require TNFalpha signaling

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12 December 2020

W.H.O. cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: mortality follow-up. Report of the Committee of Principal Investigators

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12 December 2020

Effect of dietary selenium on the induction of altered hepatic foci and hepatic tumors by the peroxisome proliferator ciprofibrate.

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12 December 2020

Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha

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12 December 2020

Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators

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12 December 2020

Induction of hepatic peroxisome proliferation in nonrodent species, including primates

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12 December 2020

Effects of p-chlorophenoxyisobutyric acid (CPIB) on the human liver

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12 December 2020

Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene

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12 December 2020

WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: final mortality follow-up. Report of the Committee of Principal Investigators

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12 December 2020

Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter

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12 December 2020

Effects of the peroxisome proliferators ciprofibrate and perfluorodecanoic acid on hepatic cellular antioxidants and lipid peroxidation in rats

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12 December 2020

Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.

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12 December 2020

A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Report from the Committee of Principal Investigators

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12 December 2020

Peroxisome proliferator-activated receptors: structures and function

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12 December 2020

Morphometric study of human hepatic cell modifications induced by fenofibrate

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12 December 2020

Light and electron microscopy of liver in hyperlipoproteinemic patients under long-term gemfibrozil treatment

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12 December 2020

Mitogenic effect in mouse liver induced by a hypolipidemic drug, nafenopin

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12 December 2020

Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay

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12 December 2020

PPARalpha agonist-induced rodent tumors: modes of action and human relevance

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12 December 2020

A conserved tripeptide sorts proteins to peroxisomes

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12 December 2020

Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene

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12 December 2020

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

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12 December 2020

Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.

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12 December 2020

Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARalpha

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12 December 2020

Differential induction and regulation of peroxisomal enzymes: predictive value of peroxisome proliferation in identifying certain nonmutagenic carcinogens.

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12 December 2020

Role of oxidative stress in peroxisome proliferator-mediated carcinogenesis

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12 December 2020

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

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12 December 2020

The Helsinki Heart Study: an 8.5-year safety and mortality follow-up

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12 December 2020

Regulation of cytokine receptor signaling by nuclear hormone receptors: a new paradigm for receptor interaction

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12 December 2020

Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha

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12 December 2020

Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease

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12 December 2020

Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis

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12 December 2020

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

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12 December 2020

Association between the PPARalpha-L162V polymorphism and components of the metabolic syndrome

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12 December 2020

Influence of fenofibrate on cellular and subcellular liver structure in hyperlipidemic patients

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12 December 2020

Variation at position 162 of peroxisome proliferator-activated receptor alpha does not influence the effect of fibrates on cholesterol or triacylglycerol concentrations in hyperlipidaemic subjects

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12 December 2020

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

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12 December 2020

Lack of peroxisome proliferation in marmoset liver following treatment with ciprofibrate for 3 years

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12 December 2020

Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator, [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14, 643), in rat and mouse liver

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12 December 2020

A quantitative analysis of fine structure and drug metabolism in livers of clofibrate-treated young adult and retired breeder rats

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12 December 2020

Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidemic peroxisome proliferators

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12 December 2020

Fibrate treatment does not modify the expression of acyl coenzyme A oxidase in human liver

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12 December 2020

Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2

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12 December 2020

Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmoset

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12 December 2020

Ligand and coactivator recruitment preferences of peroxisome proliferator activated receptor alpha

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12 December 2020

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

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12 December 2020

Influences of the PPAR alpha-L162V polymorphism on plasma HDL(2)-cholesterol response of abdominally obese men treated with gemfibrozil

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12 December 2020

NATURE OF THE HEPATOMEGALIC EFFECT PRODUCED BY ETHYL-CHLOROPHENOXY-ISOBUTYRATE IN THE RAT

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12 December 2020

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

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12 December 2020

Species differences in ciprofibrate induction of hepatic cytochrome p450 4A1 and peroxisome proliferation

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12 December 2020

Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters

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12 December 2020

Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators

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12 December 2020

trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals

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12 December 2020

Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease

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12 December 2020

Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate

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12 December 2020

Tumor necrosis factor alpha is not required for WY14,643-induced cell proliferation

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12 December 2020

Variation in the PPARα gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects

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12 December 2020

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

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12 December 2020

Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver

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12 December 2020

Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation

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12 December 2020

Coregulator function: a key to understanding tissue specificity of selective receptor modulators

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12 December 2020

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers

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12 December 2020

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

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12 December 2020

Effects of peroxisome proliferators on antioxidant enzymes and antioxidant vitamins in rats and hamsters.

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12 December 2020

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

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12 December 2020

Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator.

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12 December 2020

The coregulator exchange in transcriptional functions of nuclear receptors

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12 December 2020

A Val227Ala polymorphism in the peroxisome proliferator activated receptor alpha (PPARalpha) gene is associated with variations in serum lipid levels

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12 December 2020

Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity

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12 December 2020

The mechanisms of action of PPARs

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12 December 2020

A truncated human peroxisome proliferator-activated receptor alpha splice variant with dominant negative activity.

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12 December 2020

Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor ex

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12 December 2020

A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines

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12 December 2020

Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.

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12 December 2020

10.1007/S00109-005-0678-9

Identifiers

DOI

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12 August 2017

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