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Emerging role of RNA•DNA hybrids in C9orf72-linked neurodegeneration.
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Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
review article
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stated in
Europe PubMed Central
title
Emerging role of RNA•DNA hybrids in C9orf72-linked neurodegeneration
(English)
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stated in
Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
main subject
neurodegeneration
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inferred from title
author
Eric A J Simko
series ordinal
3
1 reference
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Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
author name string
Jiou Wang
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
Aaron R Haeusler
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
publication date
1 January 2015
1 reference
stated in
Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
number of pages
7
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inferred from page(s)
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Cell Cycle
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stated in
Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
volume
14
1 reference
stated in
Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
page(s)
526-532
1 reference
stated in
Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
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Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion
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RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
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C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease
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The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures
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Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS
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The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.
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1 October 2017
Repeat expansions in the C9ORF72 gene contribute to Alzheimer's disease in Caucasians
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1 October 2017
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1 October 2017
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1 October 2017
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1 October 2017
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1 October 2017
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1 October 2017
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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
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1 October 2017
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
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1 October 2017
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1 October 2017
RNA-mediated neurodegeneration in repeat expansion disorders
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1 October 2017
R loops stimulate genetic instability of CTG.CAG repeats
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1 October 2017
The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression
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1 October 2017
Ribonuclease H: the enzymes in eukaryotes
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1 October 2017
A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro
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1 October 2017
Expandable DNA repeats and human disease.
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1 October 2017
Trinucleotide Repeat Disorders
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1 October 2017
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection
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1 October 2017
Repeat instability: mechanisms of dynamic mutations
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
The GAA*TTC triplet repeat expanded in Friedreich's ataxia impedes transcription elongation by T7 RNA polymerase in a length and supercoil dependent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
A novel pairing process promoted by Escherichia coli RecA protein: inverse DNA and RNA strand exchange
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
RecA protein-dependent R-loop formation in vitro.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
The sen1(+) gene of Schizosaccharomyces pombe, a homologue of budding yeast SEN1, encodes an RNA and DNA helicase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
Hybridization of RNA to double-stranded DNA: formation of R-loops
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
1 October 2017
Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
2 July 2018
The homologous recombination machinery modulates the formation of RNA-DNA hybrids and associated chromosome instability.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
2 July 2018
C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
2 July 2018
A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
2 July 2018
Effects of Friedreich's ataxia (GAA)n*(TTC)n repeats on RNA synthesis and stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
2 July 2018
Escherichia coli DNA topoisomerase I inhibits R-loop formation by relaxing transcription-induced negative supercoiling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
2 July 2018
Hypermethylation of the CpG-island near the C9orf72 G₄C₂-repeat expansion in FTLD patients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
23 September 2018
C9ORF72 hexanucleotide repeat expansion as a rare cause of bipolar disorder
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
23 September 2018
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
23 September 2018
Characterization of the repeat expansion size in C9orf72 in amyotrophic lateral sclerosis and frontotemporal dementia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
23 September 2018
Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
23 September 2018
Bipolar affective disorder preceding frontotemporal dementia in a patient with C9ORF72 mutation: is there a genetic link between these two disorders?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
23 September 2018
Analysis of the hexanucleotide repeat in C9ORF72 in Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
23 September 2018
C9orf72 repeat expansions in patients with ALS and FTD.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
23 September 2018
A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
23 September 2018
Inhibitory effects of expanded GAA.TTC triplet repeats from intron I of the Friedreich ataxia gene on transcription and replication in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614400
retrieved
23 September 2018
Stability and Properties of Double and Triple Helices: Dramatic Effects of RNA or DNA Backbone Composition
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25590632
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25590632
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Human telomere RNA and DNA form an intermolecular G-quadruplex
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25590632
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1080/15384101.2014.995490
1 reference
stated in
Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
PMC publication ID
4614400
1 reference
stated in
Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
PubMed publication ID
25590632
1 reference
stated in
Europe PubMed Central
PMC publication ID
4614400
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25590632%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 February 2020
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