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R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
title
R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
main subject
gene silencing
0 references
Friedreich ataxia
1 reference
based on heuristic
inferred from title
fragile X syndrome
1 reference
based on heuristic
inferred from title
author
Richard Wade-Martins
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
author name string
Matthias Groh
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
Michele M P Lufino
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
Natalia Gromak
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
publication date
1 May 2014
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
published in
PLOS Genetics
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
volume
10
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
issue
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
page(s)
e1004318
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
copyright license
Creative Commons Attribution 4.0 International
start time
1 May 2014
1 reference
stated in
April 2022 Public Data File from Crossref
copyright status
copyrighted
0 references
cites work
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome
1 reference
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PubMed Central
reference URL
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13 July 2018
A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.
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PubMed Central
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13 July 2018
GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
The sub-nanomolar binding of DNA-RNA hybrids by the single-chain Fv fragment of antibody S9.6.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instability
1 reference
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PubMed Central
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13 July 2018
R loops: from transcription byproducts to threats to genome stability
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13 July 2018
Is Friedreich ataxia an epigenetic disorder?
1 reference
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13 July 2018
R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
DNA-RNA hybrid formation mediates RNAi-directed heterochromatin formation.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Molecular mechanisms of fragile X syndrome: a twenty-year perspective
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia
1 reference
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PubMed Central
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13 July 2018
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination
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PubMed Central
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13 July 2018
Friedreich's ataxia: past, present and future
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13 July 2018
Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Repeat instability as the basis for human diseases and as a potential target for therapy
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
R loops stimulate genetic instability of CTG.CAG repeats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Ribonuclease H: the enzymes in eukaryotes
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
DNA triplexes and Friedreich ataxia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Repeat-induced epigenetic changes in intron 1 of the frataxin gene and its consequences in Friedreich ataxia
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination
1 reference
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PubMed Central
reference URL
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13 July 2018
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability
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PubMed Central
reference URL
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13 July 2018
Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination
1 reference
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PubMed Central
reference URL
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13 July 2018
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Characterization of monoclonal antibody to DNA.RNA and its application to immunodetection of hybrids
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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13 July 2018
Detection of interruptions in the GAA trinucleotide repeat expansion in the FXN gene of Friedreich ataxia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
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27 September 2018
Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4006715
retrieved
27 September 2018
Impairment of transcription elongation by R-loops in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24787137
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1371/JOURNAL.PGEN.1004318
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
PMC publication ID
4006715
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
PubMed publication ID
24787137
1 reference
stated in
Europe PubMed Central
PMC publication ID
4006715
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24787137%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
ResearchGate publication ID
262023456
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