(Q37696952)

22 August 2017

1 reference

title

Repeat instability as the basis for human diseases and as a potential target for therapy (English)

1 reference

22 August 2017

Arturo López Castel

1

1 reference

22 August 2017

John D Cleary

series ordinal

2

1 reference

22 August 2017

Christopher E Pearson

series ordinal

3

1 reference

22 August 2017

publication date

1 March 2010

1 reference

Nature Reviews Molecular Cell Biology

22 August 2017

published in

1 reference

22 August 2017

volume

11

1 reference

22 August 2017

issue

3

1 reference

22 August 2017

page(s)

165-170

1 reference

https://scigraph.springernature.com/pub.10.1038/nrm2854

22 August 2017

exact match

0 references

cites work

Repeat instability: mechanisms of dynamic mutations

1 reference

Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset

31 March 2020

1 reference

The contribution of <i>cis</i>-elements to disease-associated repeat instability: clinical and experimental evidence

31 March 2020

1 reference

DNA instability in postmitotic neurons

31 March 2020

1 reference

Regional FMRP deficits and large repeat expansions into the full mutation range in a new Fragile X premutation mouse model

31 March 2020

1 reference

CTG trinucleotide repeat "big jumps": large expansions, small mice

31 March 2020

1 reference

Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline

31 March 2020

1 reference

ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice

31 March 2020

1 reference

CTG repeat instability in a human embryonic stem cell line carrying the myotonic dystrophy type 1 mutation.

31 March 2020

1 reference

Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos

31 March 2020

1 reference

Human embryonic stem cell models of Huntington disease.

31 March 2020

1 reference

Slipping while sleeping? Trinucleotide repeat expansions in germ cells

31 March 2020

1 reference

Checkpoint responses to unusual structures formed by DNA repeats.

31 March 2020

1 reference

Huntingtin triplet-repeat locus is stable under long-term Fen1 knockdown in human cells

31 March 2020

1 reference

CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair

31 March 2020

1 reference

Mrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms.

31 March 2020

1 reference

Large-scale expansions of Friedreich's ataxia GAA repeats in yeast

31 March 2020

1 reference

Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae

31 March 2020

1 reference

Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice.

31 March 2020

1 reference

(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition

31 March 2020

1 reference

MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice

31 March 2020

1 reference

Mutagenic roles of DNA "repair" proteins in antibody diversity and disease-associated trinucleotide repeat instability

31 March 2020

1 reference

Incision-dependent and error-free repair of (CAG)(n)/(CTG)(n) hairpins in human cell extracts

31 March 2020

1 reference

Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair

31 March 2020

1 reference

Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro.

31 March 2020

1 reference

Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion.

31 March 2020

1 reference

Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice

31 March 2020

1 reference

Structure-dependent DNA damage and repair in a trinucleotide repeat sequence.

31 March 2020

1 reference

CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease

31 March 2020

1 reference

Transcription promotes contraction of CAG repeat tracts in human cells

31 March 2020

1 reference

R loops stimulate genetic instability of CTG.CAG repeats

31 March 2020

1 reference

SCA8 CAG/CTG expansions, a tale of two TOXICities: a unique or common case?

31 March 2020

1 reference

An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals

31 March 2020

1 reference

SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination

31 March 2020

1 reference

CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination

31 March 2020

1 reference

The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues

31 March 2020

1 reference

DNA methylation in intron 1 of the frataxin gene is related to GAA repeat length and age of onset in Friedreich ataxia patients.

31 March 2020

1 reference

A Z-DNA sequence reduces slipped-strand structure formation in the myotonic dystrophy type 2 (CCTG) x (CAGG) repeat

31 March 2020

1 reference

Chromatin remodeling in the noncoding repeat expansion diseases

31 March 2020

1 reference

Highly unstable sequence interruptions of the CTG repeat in the myotonic dystrophy gene

31 March 2020

1 reference

A genetic defect caused by a triplet repeat expansion in Arabidopsis thaliana

31 March 2020

1 reference

Expanded repeat in canine epilepsy

31 March 2020

1 reference

Unstable tandem repeats in promoters confer transcriptional evolvability

31 March 2020

1 reference

Replication Inhibitors Modulate Instability of an Expanded Trinucleotide Repeat at the Myotonic Dystrophy Type 1 Disease Locus in Human Cells

31 March 2020

1 reference

Chemotherapeutic deletion of CTG repeats in lymphoblast cells from DM1 patients

31 March 2020

1 reference

Chemically induced increases and decreases in the rate of expansion of a CAG*CTG triplet repeat

31 March 2020

1 reference

Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells

31 March 2020

1 reference

Expandable DNA repeats and human disease.

31 March 2020

1 reference

A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro

31 March 2020

1 reference

Variant CCG and GGC repeats within the CTG expansion dramatically modify mutational dynamics and likely contribute toward unusual symptoms in some myotonic dystrophy type 1 patients.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20177394

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM2854

1 reference

22 August 2017

1 reference