Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q36189311)
Watch
English
Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation.
scientific article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
title
Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
main subject
microRNA
1 reference
based on heuristic
inferred from title
non-small-cell lung carcinoma
1 reference
based on heuristic
inferred from title
author
Frank J. Slack
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
author name string
Carlos Stahlhut
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
language of work or name
English
1 reference
based on heuristic
inferred from title
publication date
25 February 2015
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
published in
Cell Cycle
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
volume
14
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
issue
13
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
page(s)
2171-2180
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
cites work
A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Aberrant regulation and function of microRNAs in cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
MicroRNA-34a overcomes HGF-mediated gefitinib resistance in EGFR mutant lung cancer cells partly by targeting MET.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
In-depth analysis shows synergy between erlotinib and miR-34a
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Quantification of therapeutic miRNA mimics in whole blood from nonhuman primates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
MicroRNAs and the cancer phenotype: profiling, signatures and clinical implications
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
miR-34 - a microRNA replacement therapy is headed to the clinic
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Regression of murine lung tumors by the let-7 microRNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
HuR recruits let-7/RISC to repress c-Myc expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Beyond doublet chemotherapy for advanced non-small-cell lung cancer: combination of targeted agents with first-line chemotherapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Bevacizumab and erlotinib: a promising new approach to the treatment of advanced NSCLC.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
The MYCN oncogene is a direct target of miR-34a
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Selective blockade of microRNA processing by Lin28
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
The role of microRNAs in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Lung cancer in never smokers--a different disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
p53-mediated activation of miRNA34 candidate tumor-suppressor genes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
A microRNA component of the p53 tumour suppressor network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Epidermal growth factor receptor mutations in lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
RAS is regulated by the let-7 microRNA family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Molecular genetics of lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Smoking molecular damage in bronchial epithelium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Focus on lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Early glandular neoplasia of the lung
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
EGFR and cancer prognosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Cisplatin, etoposide, and paclitaxel in the treatment of patients with extensive small-cell lung carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
The epidermal growth factor receptor and its inhibition in cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
1 October 2017
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
22 September 2018
Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
22 September 2018
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
22 September 2018
Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
22 September 2018
EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
22 September 2018
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
22 September 2018
Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lun
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4615025
retrieved
22 September 2018
Identifiers
DOI
10.1080/15384101.2014.1003008
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
PMC publication ID
4615025
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
PubMed publication ID
25714397
1 reference
stated in
Europe PubMed Central
PMC publication ID
4615025
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714397%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
