(Q36215920)

English

PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition

scientific article

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scholarly article

1 reference

Europe PubMed Central

12 August 2017

PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition (English)

1 reference

Europe PubMed Central

12 August 2017

author name string

Samuel W Brady

1

1 reference

Europe PubMed Central

12 August 2017

Jian Zhang

2

1 reference

Europe PubMed Central

12 August 2017

Ming-Horng Tsai

3

1 reference

Europe PubMed Central

12 August 2017

Dihua Yu

4

1 reference

Europe PubMed Central

12 August 2017

publication date

1 January 2015

1 reference

Europe PubMed Central

12 August 2017

Cancer Biology and Therapy

1 reference

Europe PubMed Central

12 August 2017

16

1 reference

Europe PubMed Central

12 August 2017

3

1 reference

Europe PubMed Central

12 August 2017

402-411

1 reference

Europe PubMed Central

12 August 2017

Tumour heterogeneity and the evolution of polyclonal drug resistance

1 reference

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Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models

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The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells

1 reference

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1 October 2017

Adverse events associated with mTOR inhibitors

1 reference

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1 October 2017

PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells

1 reference

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Concomitant targeting of tumor cells and induction of T-cell response synergizes to effectively inhibit trastuzumab-resistant breast cancer

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mTOR signaling in growth control and disease

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PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib

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1 October 2017

Molecular predictors of response to trastuzumab and lapatinib in breast cancer.

1 reference

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1 October 2017

Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.

1 reference

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1 October 2017

Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

1 reference

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1 October 2017

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

1 reference

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1 October 2017

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

1 reference

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1 October 2017

IAPs: more than just inhibitors of apoptosis proteins

1 reference

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1 October 2017

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Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.

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1 October 2017

The inhibitors of apoptosis (IAPs) as cancer targets

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1 October 2017

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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A census of human cancer genes

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Regulation of survivin function by Hsp90

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Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.

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22 September 2018

Identifiers

10.1080/15384047.2014.1002693

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

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