(Q36219281)

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Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Sergio I Valdés-Ferrer

object named as

Sergio I Valdés-Ferrer

2

0 references

Valentin A Pavlov

object named as

Valentin A Pavlov

11

0 references

Kevin J. Tracey

object named as

Kevin J Tracey

10

0 references

Sangeeta S Chavan

8

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Sangeeta S Chavan

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

6

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Kai Fan Cheng

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Mahendar Ochani

4

object named as

Mahendar Ochani

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Mauricio Rosas-Ballina

1

object named as

Mauricio Rosas-Ballina

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Meghan E Dancho

3

object named as

Meghan E Dancho

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Peder S Olofsson

7

object named as

Peder S Olofsson

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

author name string

David Katz

5

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Yousef Al-Abed

9

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

publication date

23 July 2014

1 reference

Europe PubMed Central

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12 August 2017

Brain, Behavior, and Immunity

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

44

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

19-27

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Vagus nerve controls resolution and pro-resolving mediators of inflammation

1 reference

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1 October 2017

Getting nervous about immunity

1 reference

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1 October 2017

High-mobility group box 1 mediates persistent splenocyte priming in sepsis survivors: evidence from a murine model

1 reference

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1 October 2017

Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis

1 reference

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1 October 2017

HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors.

1 reference

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1 October 2017

Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias

1 reference

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1 October 2017

Sepsis definitions: time for change

1 reference

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1 October 2017

Immune-neural connections: how the immune system's response to infectious agents influences behavior

1 reference

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1 October 2017

The vagus nerve and the inflammatory reflex--linking immunity and metabolism

1 reference

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1 October 2017

Muscarinic mechanisms in psychotic disorders

1 reference

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1 October 2017

Rethinking inflammation: neural circuits in the regulation of immunity

1 reference

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1 October 2017

Neural reflexes in inflammation and immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia

1 reference

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1 October 2017

Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Galantamine alleviates inflammation and other obesity-associated complications in high-fat diet-fed mice.

1 reference

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1 October 2017

Immune system to brain signaling: neuropsychopharmacological implications.

1 reference

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1 October 2017

Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Comprehensive assessment of chemokine expression profiles by flow cytometry

1 reference

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1 October 2017

Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Identification of splenic reservoir monocytes and their deployment to inflammatory sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Reflex control of immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Immunodesign of experimental sepsis by cecal ligation and puncture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Cholinergic modulation of inflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis

1 reference

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1 October 2017

Physiology and immunology of the cholinergic antiinflammatory pathway

1 reference

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1 October 2017

Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis

1 reference

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1 October 2017

Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

The cholinergic anti-inflammatory pathway

1 reference

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1 October 2017

Neural regulators of innate immune responses and inflammation.

1 reference

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1 October 2017

The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation

1 reference

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1 October 2017

The inflammatory reflex

1 reference

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1 October 2017

AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease

1 reference

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1 October 2017

Vagal immune-to-brain communication: a visceral chemosensory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

Cellular and molecular mechanisms of TNF protection in septic peritonitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624331

1 October 2017

PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man.

1 reference

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1 October 2017

Characterization of vagal innervation to the rat celiac, suprarenal and mesenteric ganglia

1 reference

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1 October 2017

Lessons learned at the intersection of immunology and neuroscience

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29 June 2018

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors

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29 June 2018

Origin of noradrenergic innervation of the spleen in rats

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29 June 2018

Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice-Possible involvement of muscarinic receptors

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22 September 2018

Controlling inflammation: the cholinergic anti-inflammatory pathway

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22 September 2018

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

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22 September 2018

Brain proton magnetic resonance spectroscopy in Alzheimer disease: changes after treatment with xanomeline

1 reference

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22 September 2018

The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease.

1 reference

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Standardization of the sucrose-potassium phosphate-glyoxylic acid histofluorescence method for tissue monoamines

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based on heuristic

inferred from PubMed ID database lookup

Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25063706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Injury of the blood brain barrier and up-regulation of icam-1 in polymicrobial sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25063706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25063706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of TNF and TNF receptor type 2 for LPS-induced protection from lethal septic peritonitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25063706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory processes in schizophrenia: a promising neuroimmunological target for the treatment of negative/cognitive symptoms and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/25063706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.BBI.2014.07.010

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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