(Q36219689)

12 August 2017

1 reference

title

New targets for neuropathic pain therapeutics (English)

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12 August 2017

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Ross A Kinloch

1

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12 August 2017

Peter J Cox

series ordinal

2

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12 August 2017

language of work or name

English

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publication date

1 August 2005

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Expert Opinion on Therapeutic Targets

12 August 2017

published in

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12 August 2017

volume

9

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12 August 2017

issue

4

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12 August 2017

page(s)

685-698

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Molecular mechanisms of nociception

12 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Neuronal plasticity: increasing the gain in pain

21 January 2018

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An overview of neuropathic pain: syndromes, symptoms, signs, and several mechanisms.

21 January 2018

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Chronic pain: mechanisms and treatment

21 January 2018

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Neuropathic pain: aetiology, symptoms, mechanisms, and management

21 January 2018

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Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

What should we be measuring in behavioral studies of chronic pain in animals?

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Pathways that elicit long-term changes in gene expression in nociceptive neurons following nerve injury: contributions to neuropathic pain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Glial activation and pathological pain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

The role of voltage-gated sodium channels in neuropathic pain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Strategies to identify ion channel modulators: current and novel approaches to target neuropathic pain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Targeting Ca2+ channels to treat pain: T-type versus N-type.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

The therapeutic potential of Na+ and Ca2+ channel blockers in pain management

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Voltage-gated sodium channels and hyperalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Plasticity of TTX-sensitive sodium channels PN1 and brain III in injured human nerves

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Pre- and postsynaptic contributions of voltage-dependent Ca2+ channels to nociceptive transmission in rat spinal lamina I neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Ziconotide: neuronal calcium channel blocker for treating severe chronic pain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Reversal of experimental neuropathic pain by T-type calcium channel blockers

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Thalamic Control of Visceral Nociception Mediated by T-Type Ca 2+ Channels

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Auxiliary subunits: essential components of the voltage-gated calcium channel complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Spinal dorsal horn calcium channel alpha2delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

3-substituted GABA analogs with central nervous system activity: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Vanilloid (capsaicin) receptors in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Increased Expression of Vanilloid Receptor 1 on Myelinated Primary Afferent Neurons Contributes to the Antihyperalgesic Effect of Capsaicin Cream in Diabetic Neuropathic Pain in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

P2X receptors in peripheral neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

siRNA relieves chronic neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Endocannabinoids in pain modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Evidence for a selective role of the delta-opioid agonist [8R-(4bS*,8aalpha,8abeta, 12bbeta)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoline hydrochloride (SB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Mu-opioid receptor knockout prevents changes in delta-opioid receptor trafficking induced by chronic inflammatory pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Up-regulation and trafficking of delta opioid receptor in a model of chronic inflammation: implications for pain control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Effects of peripheral nerve injury on delta opioid receptor (DOR) immunoreactivity in the rat spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Glutamate receptors and nociception: implications for the drug treatment of pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Sensory neuron-specific receptor activation elicits central and peripheral nociceptive effects in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Identification of a G protein-coupled receptor specifically responsive to beta-alanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Identification and characterization of two G protein-coupled receptors for neuropeptide FF

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Neuropeptide FF receptor 2 (NPFF2) is localized to pain-processing regions in the primate spinal cord and the lower level of the medulla oblongata

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Rodent strain differences in the NPFF1 and NPFF2 receptor distribution and density in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

MAPK activation in nociceptive neurons and pain hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Identification of MEK1 as a novel target for the treatment of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Signaling of ATP receptors in glia-neuron interaction and pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Potential applications of siRNA for pain therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Human chromaffin cell graft into the CSF for cancer pain management: a prospective phase II clinical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Cell therapy for neuropathic pain in spinal cord injuries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Embryonic stem cells in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

Gene therapy of chronic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.685

21 January 2018

Identifiers

DOI

10.1517/14728222.9.4.685

1 reference

12 August 2017

1 reference