(Q36223954)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

4

1 reference

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30 January 2020

author name string

C-Y Chen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Y-H Weng

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

K-Y Chien

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

T-H Yeh

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Y-P Cheng

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

C-S Lu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

H-L Wang

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

language of work or name

1 reference

27 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

Cell Death & Differentiation

30 January 2020

published in

1 reference

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30 January 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

page(s)

1623-1633

1 reference

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30 January 2020

issue

10

1 reference

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describes a project that uses

30 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3438494/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/cdd.2012.42

0 references

cites work

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

1 reference

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Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation

1 October 2017

1 reference

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MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

1 October 2017

1 reference

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Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

1 October 2017

1 reference

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

1 October 2017

1 reference

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The genetics of Parkinson's syndromes: a critical review

1 October 2017

1 reference

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The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

1 October 2017

1 reference

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Parkinson's disease: from monogenic forms to genetic susceptibility factors

1 October 2017

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The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

1 October 2017

1 reference

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Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

1 October 2017

1 reference

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Apoptotic mechanisms in mutant LRRK2-mediated cell death

1 October 2017

1 reference

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Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease

1 October 2017

1 reference

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G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies

1 October 2017

1 reference

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

1 October 2017

1 reference

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

1 October 2017

1 reference

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

1 October 2017

1 reference

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Parkinsonism, Lrrk2 G2019S, and tau neuropathology

1 October 2017

1 reference

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

1 October 2017

1 reference

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

1 October 2017

1 reference

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LRRK2 in Parkinson's disease: protein domains and functional insights

1 October 2017

1 reference

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Biochemical and pathological characterization of Lrrk2.

1 October 2017

1 reference

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Life in the balance: how BH3-only proteins induce apoptosis.

1 October 2017

1 reference

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A common LRRK2 mutation in idiopathic Parkinson's disease

1 October 2017

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

1 October 2017

1 reference

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 October 2017

1 reference

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Mixed-lineage kinases: a target for the prevention of neurodegeneration

1 October 2017

1 reference

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Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor.

1 October 2017

1 reference

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A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

1 October 2017

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Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 October 2017

1 reference

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 October 2017

1 reference

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JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438494

Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons.

29 June 2018

1 reference

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Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438494

Quantitative micro-SPECT/CT for detecting focused ultrasound-induced blood-brain barrier opening in the rat.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438494

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438494

Improved neuronal transgene expression from an AAV-2 vector with a hybrid CMV enhancer/PDGF-beta promoter

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438494

Control of death receptor and mitochondrial-dependent apoptosis by c-Jun N-terminal kinase in hippocampal CA1 neurones following global transient ischaemia

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438494

Specific pathophysiological functions of JNK isoforms in the brain

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438494

Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438494

22 September 2018

Identifiers

DOI

10.1038/CDD.2012.42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22539006%20AND%20SRC:MED&resulttype=core&format=json