(Q24322792)

MAP kinase kinase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Marius Ueffing

Christian Johannes Gloeckner

4

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1

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Karsten Boldt

3

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author name string

Annette Schumacher

Journal of Neurochemistry

2

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language of work or name

English

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publication date

May 2009

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published in

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volume

109

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page(s)

959-68

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issue

4

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cites work

MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease.

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A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes

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Lrrk2 pathogenic substitutions in Parkinson's disease

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Roc, a Ras/GTPase domain in complex proteins

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

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Control of a kinesin-cargo linkage mechanism by JNK pathway kinases

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Structural basis for the interaction of TAK1 kinase with its activating protein TAB1.

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Regulation of protein kinases; controlling activity through activation segment conformation

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Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases

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Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

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Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease

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LRRK2 in Parkinson's disease: protein domains and functional insights

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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

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Mixed-lineage kinase control of JNK and p38 MAPK pathways

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

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LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

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LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

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Genetics of Parkinson's disease: LRRK2 on the rise

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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

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7 January 2021

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

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Apoptotic mechanisms in mutant LRRK2-mediated cell death

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Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

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7 January 2021

The Parkinson disease gene LRRK2: evolutionary and structural insights

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SWISS-MODEL: An automated protein homology-modeling server

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The protein kinase complement of the human genome

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Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06024.X

7 January 2021

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06024.X

7 January 2021

The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06024.X

7 January 2021

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06024.X

7 January 2021

LRRK2 mutations in Parkinson disease

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06024.X

7 January 2021

The roles of kinases in familial Parkinson's disease.

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06024.X

7 January 2021

JNK signalling: a possible target to prevent neurodegeneration.

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7 January 2021