(Q36236088)

12 August 2017

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title

Leptin: structure, function and biology (English)

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12 August 2017

Faming Zhang

1

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12 August 2017

Yanyun Chen

series ordinal

2

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12 August 2017

Mark Heiman

series ordinal

3

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12 August 2017

Richard Dimarchi

series ordinal

4

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12 August 2017

publication date

1 January 2005

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12 August 2017

published in

Vitamins and Hormones

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12 August 2017

volume

71

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12 August 2017

page(s)

345-372

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Role of leptin in the neuroendocrine response to fasting

12 August 2017

cites work

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Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme

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7 January 2021

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

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7 January 2021

Activation of downstream signals by the long form of the leptin receptor

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7 January 2021

Strategies for the delivery of leptin to the CNS.

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7 January 2021

Leptin enters the brain by a saturable system independent of insulin

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7 January 2021

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

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7 January 2021

The role of SOCS-3 in leptin signaling and leptin resistance

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7 January 2021

Identification of SOCS-3 as a potential mediator of central leptin resistance

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7 January 2021

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

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7 January 2021

The future of leptin and leptin analogues in the treatment of obesity

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7 January 2021

IRS-2 pathways integrate female reproduction and energy homeostasis

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7 January 2021

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

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7 January 2021

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

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7 January 2021

Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats

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7 January 2021

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

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7 January 2021

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss

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7 January 2021

Selective deletion of leptin receptor in neurons leads to obesity

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7 January 2021

Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.

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7 January 2021

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

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7 January 2021

Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers

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7 January 2021

Essential role of STAT3 in body weight and glucose homeostasis

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7 January 2021

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

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7 January 2021

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.

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https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

Regulation of leptin release by mammalian adipose tissue

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https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

1 reference

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7 January 2021

Partial leptin deficiency and human adiposity.

1 reference

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7 January 2021

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

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7 January 2021

Localization of leptin binding domain in the leptin receptor.

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7 January 2021

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

1 reference

7 January 2021

A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

Epitope mapping of secreted mouse leptin utilizing peripherally administered synthetic peptides

1 reference

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7 January 2021

[D-LEU-4]-OB3, a synthetic leptin agonist, improves hyperglycemic control in C57BL/6J ob/ob mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin

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7 January 2021

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

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7 January 2021

Weight-reducing effects of the plasma protein encoded by the obese gene

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7 January 2021

Management of cellular energy by the AMP-activated protein kinase system

1 reference

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7 January 2021

Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling

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7 January 2021

Leptin in the CNS: much more than a satiety signal.

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7 January 2021

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

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7 January 2021

Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells

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7 January 2021

Crystal structure of a ubiquitin-dependent degradation substrate: a three-disulfide form of lysozyme

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7 January 2021

Homology modeling of human leptin/leptin receptor complex.

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7 January 2021

Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization

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7 January 2021

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

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7 January 2021

Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance

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7 January 2021

Modulation of circulating leptin levels by its soluble receptor

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7 January 2021

Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin

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7 January 2021

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

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7 January 2021

Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor

1 reference

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7 January 2021

Leptin receptor isoforms expressed in human adipose tissue

1 reference

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7 January 2021

Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene

1 reference

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7 January 2021

Hypothalamic CART is a new anorectic peptide regulated by leptin

1 reference

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7 January 2021

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1 reference

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7 January 2021

Unraveling the multiple roles of leptin in inflammation and autoimmunity

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7 January 2021

Soluble Leptin Receptor Represents the Main Leptin Binding Activity in Human Blood

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7 January 2021

Influence of cortisol status on leptin secretion

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7 January 2021

Abnormal splicing of the leptin receptor in diabetic mice

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7 January 2021

Decreased food intake does not completely account for adiposity reduction after ob protein infusion

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7 January 2021

The effects of insulin, glucose, and pyruvate on the kinetics of leptin secretion

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7 January 2021

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

1 reference

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7 January 2021

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and, e in different mouse tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

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7 January 2021

Direct delivery of leptin to the hypothalamus using recombinant adeno-associated virus vectors results in increased therapeutic efficacy

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7 January 2021

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

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7 January 2021

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

1 reference

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7 January 2021

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

1 reference

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7 January 2021

Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity

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7 January 2021

BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry

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7 January 2021

Role of stearoyl-coenzyme A desaturase in lipid metabolism

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7 January 2021

Life without white fat: a transgenic mouse

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7 January 2021

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

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7 January 2021

Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy.

1 reference

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7 January 2021

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

1 reference

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7 January 2021

Fasting-induced activation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus

1 reference

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7 January 2021

Single intracerebroventricular bolus injection of a recombinant adenovirus expressing leptin results in reduction of food intake and body weight in both lean and obese Zucker fa/fa rats

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7 January 2021

Leptin receptor signaling and the regulation of mammalian physiology

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7 January 2021

Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia

1 reference

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7 January 2021

Intracellular signalling. Key enzyme in leptin-induced anorexia

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7 January 2021

Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity

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7 January 2021

Leptin-replacement therapy for lipodystrophy.

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7 January 2021

Phylogeny of a growth hormone-like cytokine superfamily based upon 3D structure.

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7 January 2021

Effects of the obese gene product on body weight regulation in ob/ob mice

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7 January 2021

Lipoatrophy revisited

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7 January 2021

The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding

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7 January 2021

Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis, and thermoregulation

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7 January 2021

Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity

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7 January 2021

Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action

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7 January 2021

Soluble leptin receptor and soluble receptor-bound fraction of leptin in the metabolic syndrome.

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7 January 2021

Subcloning, expression, purification, and characterization of recombinant human leptin-binding domain

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7 January 2021

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

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7 January 2021

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1 reference

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7 January 2021

Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy

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7 January 2021

The X-ray structure of a growth hormone-prolactin receptor complex

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7 January 2021

A leptin missense mutation associated with hypogonadism and morbid obesity.

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7 January 2021

Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat

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7 January 2021

Identification and expression cloning of a leptin receptor, OB-R

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7 January 2021

Leptin: fundamental aspects

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7 January 2021

A frameshift mutation in human MC4R is associated with a dominant form of obesity

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7 January 2021

Leptin and soluble leptin receptor levels in obese and weight-losing individuals

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7 January 2021

Diet-induced obese mice develop peripheral, but not central, resistance to leptin

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7 January 2021

Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling.

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7 January 2021

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

Aberrant expression and possible involvement of the leptin receptor in endometrial cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

Crystal structure of the obese protein leptin-E100

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

Positional cloning of the mouse obese gene and its human homologue

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2805%2971012-8

7 January 2021

10.1016/S0083-6729(05)71012-8

Identifiers

DOI

1 reference

12 August 2017

1 reference