(Q36239212)

13 August 2017

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title

When epigenetics kills: MLL fusion proteins in leukemia (English)

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13 August 2017

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Robert K Slany

1

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13 August 2017

1 March 2005

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13 August 2017

Hematological Oncology

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13 August 2017

23

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13 August 2017

1-9

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13 August 2017

1

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The molecular basis of leukemia

13 August 2017

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The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

21 January 2018

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Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice

21 January 2018

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PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins

21 January 2018

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HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells

21 January 2018

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Significance of a (4;11) translocation in acute lymphoblastic leukemia

21 January 2018

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7 January 2021

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

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7 January 2021

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7 January 2021

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.

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7 January 2021

Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

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7 January 2021

MLL amplification in myeloid malignancies: clinical, molecular, and cytogenetic findings

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7 January 2021

Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies

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7 January 2021

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7 January 2021

Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further process

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7 January 2021

A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells.

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7 January 2021

Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

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7 January 2021

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

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7 January 2021

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

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7 January 2021

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

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7 January 2021

Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila

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7 January 2021

Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

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7 January 2021

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

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7 January 2021

MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis

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7 January 2021

Altered Hox expression and segmental identity in Mll-mutant mice

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7 January 2021

Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

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7 January 2021

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

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7 January 2021

MLL targets SET domain methyltransferase activity to Hox gene promoters

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7 January 2021

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

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7 January 2021

The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex

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7 January 2021

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

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7 January 2021

Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex

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7 January 2021

Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation

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7 January 2021

AT-hook motifs identified in a wide variety of DNA-binding proteins

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7 January 2021

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

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7 January 2021

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

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7 January 2021

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

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7 January 2021

A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells

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7 January 2021

Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells

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7 January 2021

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

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7 January 2021

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

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7 January 2021

Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?

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7 January 2021

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

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7 January 2021

The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis

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7 January 2021

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer

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7 January 2021

Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia

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7 January 2021

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

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7 January 2021

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7 January 2021

Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

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7 January 2021

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

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7 January 2021

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

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7 January 2021

Common mechanism for oncogenic activation of MLL by forkhead family proteins

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7 January 2021

De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19.

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7 January 2021

Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein

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7 January 2021

Transcriptional activation is a key function encoded by MLL fusion partners

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7 January 2021

The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator

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7 January 2021

Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia

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7 January 2021

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).

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7 January 2021

EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein

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7 January 2021

ENL, the MLL fusion partner in t(11;19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t(10;11)+.

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7 January 2021

The herpes simplex virus VP16-induced complex: the makings of a regulatory switch

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7 January 2021

MLL fusion partners AF4 and AF9 interact at subnuclear foci

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7 January 2021

The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex

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7 January 2021

Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex

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7 January 2021

An RNA polymerase II elongation factor encoded by the human ELL gene

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7 January 2021

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

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7 January 2021

Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.

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7 January 2021

The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells

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7 January 2021

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.

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7 January 2021

Dimerization of MLL fusion proteins immortalizes hematopoietic cells

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7 January 2021

Gene expression profiling of pediatric acute myelogenous leukemia.

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7 January 2021

Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein

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7 January 2021

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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7 January 2021

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

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7 January 2021

Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia

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7 January 2021

The pathophysiology of HOX genes and their role in cancer.

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7 January 2021

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

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7 January 2021

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

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7 January 2021

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

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7 January 2021

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

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7 January 2021

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

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7 January 2021

Identifiers

DOI

10.1002/HON.739

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release_zusy4xpkyfae3pgc57rqkiyoau

13 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/zusy4xpkyfae3pgc57rqkiyoau

24 November 2022

mapped directly with Wikidata item

PubMed ID

16118769

1 reference

PubMed ID

16118769