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Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?
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Europe PubMed Central
PubMed publication ID
15221006
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15221006%20AND%20SRC:MED&resulttype=core&format=json
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30 December 2019
title
Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?
(English)
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PubMed publication ID
15221006
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30 December 2019
author
Theodor Dingermann
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5
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PubMed publication ID
15221006
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30 December 2019
Rolf Marschalek
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6
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PubMed publication ID
15221006
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30 December 2019
Adelheid Bursen
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Adelheid Bursen
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PubMed publication ID
15221006
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30 December 2019
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Sven Moritz
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2
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15221006
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30 December 2019
Anne Gaussmann
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3
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PubMed publication ID
15221006
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30 December 2019
Sören Moritz
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4
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PubMed publication ID
15221006
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30 December 2019
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publication date
1 August 2004
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PubMed publication ID
15221006
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30 December 2019
published in
Oncogene
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PubMed publication ID
15221006
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30 December 2019
volume
23
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PubMed publication ID
15221006
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30 December 2019
issue
37
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Europe PubMed Central
PubMed publication ID
15221006
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15221006%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
page(s)
6237-6249
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Europe PubMed Central
PubMed publication ID
15221006
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15221006%20AND%20SRC:MED&resulttype=core&format=json
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30 December 2019
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7 January 2021
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Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
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ENL, the MLL fusion partner in t(11;19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t(10;11)+.
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The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7.
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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
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Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island
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The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias
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A binding motif for Siah ubiquitin ligase.
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Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization
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Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression
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Characterization of human homologs of the Drosophila seven in absentia (sina) gene
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Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins
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Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway
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A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse.
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Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue
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Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice
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ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
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Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia
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7 January 2021
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Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death
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7 January 2021
based on heuristic
inferred from DOI database lookup
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling
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Crossref
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7 January 2021
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inferred from DOI database lookup
Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
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7 January 2021
based on heuristic
inferred from DOI database lookup
Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
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7 January 2021
based on heuristic
inferred from DOI database lookup
SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
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7 January 2021
based on heuristic
inferred from DOI database lookup
The der(11) chromosome contains the critical breakpoint junction in the 4;11, 9;11, and 11;19 translocations in acute leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
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7 January 2021
based on heuristic
inferred from DOI database lookup
EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Siah-1 binds and regulates the function of Numb
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular memory and the histone code
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The trithorax-group and polycomb-group chromatin modifiers: implications for disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasomal regulation of nuclear receptor corepressor-mediated repression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1207837
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1207837
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15221006
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15221006%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
Dimensions Publication ID
1042922754
0 references
PubMed publication ID
15221006
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15221006
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15221006%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
ResearchGate publication ID
8487343
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