(Q36240398)

English

A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26079410%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26079410%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Alzheimer's disease

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Michael W. Lutz

1

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17 February 2020

5

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Allen D Roses

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17 February 2020

author name string

Robert Saul

2

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17 February 2020

Colton Linnertz

3

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17 February 2020

Omolara-Chinue Glenn

4

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17 February 2020

Ornit Chiba-Falek

6

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17 February 2020

publication date

13 June 2015

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17 February 2020

Alzheimer's and Dementia

1 reference

Europe PubMed Central

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17 February 2020

11

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17 February 2020

10

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17 February 2020

1133-1143

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Europe PubMed Central

PMC publication ID

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17 February 2020

Resolving the complexity of the human genome using single-molecule sequencing

1 reference

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1 reference

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The landscape of human STR variation

1 reference

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1 October 2017

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.

1 reference

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1 October 2017

The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease

1 reference

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Enhancer biology and enhanceropathies

1 reference

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C9orf72 nucleotide repeat structures initiate molecular cascades of disease.

1 reference

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1 October 2017

The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes

1 reference

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The clinical and pathological phenotypes of frontotemporal dementia with C9ORF72 mutations

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Histone modifications for human epigenome analysis

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Transcriptional regulation by the Set7 lysine methyltransferase

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1 October 2017

Using genetics to enable studies on the prevention of Alzheimer's disease

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1 October 2017

ENCODE Project Writes Eulogy for Junk DNA

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1 October 2017

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

1 reference

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1 October 2017

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

1 reference

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1 October 2017

The importance of phase information for human genomics

1 reference

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Genome-wide association study confirms extant PD risk loci among the Dutch

1 reference

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1 October 2017

SNCA variant associated with Parkinson disease and plasma alpha-synuclein level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Genome-wide association study reveals genetic risk underlying Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

SNCA variants are associated with increased risk for multiple system atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Human genetic variation and its contribution to complex traits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Genomewide association study for susceptibility genes contributing to familial Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

1 reference

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1 October 2017

Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

1 October 2017

Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease

1 reference

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1 October 2017

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

1 reference

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Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels

1 reference

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1 October 2017

Multiple regions of alpha-synuclein are associated with Parkinson's disease

1 reference

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1 October 2017

Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene

1 reference

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1 October 2017

The ENCODE (ENCyclopedia Of DNA Elements) Project

1 reference

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1 October 2017

A variable dinucleotide repeat in the CFTR gene contributes to phenotype diversity by forming RNA secondary structures that alter splicing

1 reference

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1 reference

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1 October 2017

Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system

1 reference

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1 October 2017

Report of the second dementia with Lewy body international workshop: diagnosis and treatment. Consortium on Dementia with Lewy Bodies

1 reference

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1 October 2017

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1 reference

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1 October 2017

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

1 reference

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1 October 2017

Neuropathological stageing of Alzheimer-related changes

1 reference

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1 October 2017

Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease

1 reference

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29 June 2018

African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.

1 reference

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22 September 2018

Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4630109

22 September 2018

alpha-Synuclein promoter confers susceptibility to Parkinson's disease.

1 reference

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22 September 2018

Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene

1 reference

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22 September 2018

A promoter-associated polymorphic repeat modulates PAX-6 expression in human brain

1 reference

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22 September 2018

The Lewy body variant of Alzheimer disease

1 reference

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22 September 2018

The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: a commentary

1 reference

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22 September 2018

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part IX. A prospective cliniconeuropathologic study of Parkinson's features in Alzheimer's disease.

1 reference

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22 September 2018

Multiplealpha-synucleingene polymorphisms are associated with Parkinson’s disease in a Norwegian population

1 reference

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5 December 2018

-Synuclein and Parkinson disease susceptibility

1 reference

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5 December 2018

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

1 reference

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5 December 2018

Transcriptional regulation of the human type I collagen alpha2 (COL1A2) gene by the combination of two dinucleotide repeats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26079410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-synuclein gene haplotypes are associated with Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26079410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/26079410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shortened microsatellite d(CA)21 sequence down-regulates promoter activity of matrix metalloproteinase 9 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/26079410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/26079410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ENCODE project

1 reference

https://pubmed.ncbi.nlm.nih.gov/26079410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphism of NACP-Rep1 in Parkinson's disease: an etiologic link with essential tremor?

1 reference

https://pubmed.ncbi.nlm.nih.gov/26079410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional polymorphism in the matrix metalloproteinase-9 promoter as a potential risk factor for intracranial aneurysm

1 reference

https://pubmed.ncbi.nlm.nih.gov/26079410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JALZ.2015.05.011

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26079410%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26079410%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26079410%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

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