(Q36245192)

13 August 2017

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title

Making the most of a little: dosage effects in eukaryotic telomere length maintenance (English)

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13 August 2017

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Lea Harrington

1

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13 August 2017

publication date

1 January 2005

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13 August 2017

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13 August 2017

volume

13

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13 August 2017

issue

5

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13 August 2017

page(s)

493-504

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https://scigraph.springernature.com/pub.10.1007/s10577-005-0994-5

13 August 2017

exact match

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cites work

Telomere dysfunction triggers developmentally regulated germ cell apoptosis.

1 reference

https://api.crossref.org/works/10.1007%2FS10577-005-0994-5

Ku86 is essential in human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10577-005-0994-5

Repair of chromosome ends after telomere loss in Saccharomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10577-005-0994-5

The C terminus of the major yeast telomere binding protein Rap1p enhances telomere formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10577-005-0994-5

The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10577-005-0994-5

The zebrafish as a vertebrate model of functional aging and very gradual senescence

21 January 2018

1 reference

12 December 2020

The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities

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12 December 2020

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

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12 December 2020

Telomerase expression in chickens: constitutive activity in somatic tissues and down-regulation in culture

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12 December 2020

Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs

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12 December 2020

A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length

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12 December 2020

Telomere repeat binding factors: keeping the ends in check

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12 December 2020

Involvement of mammalian Mus81 in genome integrity and tumor suppression

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12 December 2020

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

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12 December 2020

Enhanced tumor formation in mice heterozygous for Blm mutation

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12 December 2020

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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12 December 2020

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

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12 December 2020

Length control of human telomeres.

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12 December 2020

The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae

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12 December 2020

Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast

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12 December 2020

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

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12 December 2020

Expression of mouse telomerase catalytic subunit in embryos and adult tissues.

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12 December 2020

Ndj1p-dependent epigenetic resetting of telomere size in yeast meiosis

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12 December 2020

The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance

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12 December 2020

Reverse transcriptase motifs in the catalytic subunit of telomerase

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12 December 2020

The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion

1 reference

12 December 2020

Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.

1 reference

12 December 2020

Dosage sensitivity and the evolution of gene families in yeast

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12 December 2020

Varying the number of telomere-bound proteins does not alter telomere length in tel1Delta cells.

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12 December 2020

Two recessive suppressors of Saccharomyces cerevisiae cho1 that are unlinked but fall in the same complementation group

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12 December 2020

Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA.

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12 December 2020

Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres

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12 December 2020

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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12 December 2020

Generation of telomere-length heterogeneity in Saccharomyces cerevisiae

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12 December 2020

Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.

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12 December 2020

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

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12 December 2020

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

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12 December 2020

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA

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12 December 2020

Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase

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12 December 2020

Telomerase levels control the lifespan of human T lymphocytes

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12 December 2020

A bulged stem tethers Est1p to telomerase RNA in budding yeast

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12 December 2020

Est1 and Cdc13 as comediators of telomerase access

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12 December 2020

Developmental and tissue-specific regulation of mouse telomerase and telomere length

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12 December 2020

Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.

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12 December 2020

Ku acts in a unique way at the mammalian telomere to prevent end joining

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12 December 2020

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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12 December 2020

Ku binds telomeric DNA in vitro

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12 December 2020

Telomerase maintains telomere structure in normal human cells.

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12 December 2020

Msh2 deficiency increases the mutation frequency in all parts of the mouse colon

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12 December 2020

Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability

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12 December 2020

Exploring the etiology of haploinsufficiency

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12 December 2020

The Est3 protein is a subunit of yeast telomerase

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12 December 2020

Telomerase activity in candidate stem cells from fetal liver and adult bone marrow

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12 December 2020

Telomere dysfunction and the initiation of genome instability.

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12 December 2020

Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.

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12 December 2020

Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity

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12 December 2020

Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiae

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12 December 2020

Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis

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12 December 2020

Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

1 reference

12 December 2020

Association of the Est1 protein with telomerase activity in yeast

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12 December 2020

Association between aplastic anaemia and mutations in telomerase RNA

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12 December 2020

Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.

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12 December 2020

Expanded repeat sequences and disease

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12 December 2020

The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression

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12 December 2020

Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis

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12 December 2020

Est1p as a cell cycle-regulated activator of telomere-bound telomerase

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12 December 2020

Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity.

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12 December 2020

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

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12 December 2020

Telomerase modulates expression of growth-controlling genes and enhances cell proliferation

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12 December 2020

TLC1: template RNA component of Saccharomyces cerevisiae telomerase

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12 December 2020

Telomere cap components influence the rate of senescence in telomerase-deficient yeast cells

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12 December 2020

Wild-derived inbred mouse strains have short telomeres

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12 December 2020

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

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12 December 2020

A DNA damage checkpoint response in telomere-initiated senescence

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12 December 2020

Telomeres and senescence: the history, the experiment, the future

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12 December 2020

Alternatives to telomerase: keeping linear chromosomes via telomeric circles

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12 December 2020

Telomere structure, function and maintenance in Arabidopsis

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12 December 2020

Unlinked noncomplementation: isolation of new conditional-lethal mutations in each of the tubulin genes of Saccharomyces cerevisiae

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12 December 2020

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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12 December 2020

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia

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12 December 2020

Progressive cis-inhibition of telomerase upon telomere elongation.

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12 December 2020

Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma.

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12 December 2020

Alternative lengthening of telomeres, telomerase, and cancer.

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12 December 2020

Haploinsufficiency of mTR results in defects in telomere elongation

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12 December 2020

Rap1 affects the length and heterogeneity of human telomeres

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12 December 2020

Different telomere damage signaling pathways in human and mouse cells

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12 December 2020

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.

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12 December 2020

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12 December 2020

A critical role for telomeres in suppressing and facilitating carcinogenesis

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12 December 2020

Homologous recombination generates T-loop-sized deletions at human telomeres

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12 December 2020

Does a sentinel or a subset of short telomeres determine replicative senescence?

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12 December 2020

Role of human Ku86 in telomere length maintenance and telomere capping

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12 December 2020

A mutant with a defect in telomere elongation leads to senescence in yeast

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12 December 2020

Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice

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12 December 2020

Rap1p and telomere length regulation in yeast.

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12 December 2020

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

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12 December 2020

Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeres

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12 December 2020

Essential role of mouse telomerase in highly proliferative organs

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12 December 2020

Combined haploinsufficiency for ATM and RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair dynamics.

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12 December 2020

Synthetic dosage lethality

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12 December 2020

DNA damage foci at dysfunctional telomeres

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12 December 2020

Yeast genome-wide drug-induced haploinsufficiency screen to determine drug mode of action

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12 December 2020

Alternative lengthening of telomeres: dangerous road less travelled

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12 December 2020

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

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12 December 2020

The yeast VPS genes affect telomere length regulation

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12 December 2020

Telomerase activity, cell proliferation, and cancer

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12 December 2020

End Resection Initiates Genomic Instability in the Absence of Telomerase

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12 December 2020

Mutations in the pho80 gene confer permeability to 5'-mononucleotides in Saccharomyces cerevisiae

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12 December 2020

Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenita

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12 December 2020

A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation

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12 December 2020

A novel mechanism for telomere size control in Saccharomyces cerevisiae

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12 December 2020

Identification of telomere-dependent "senescence-like" arrest in mouse embryonic fibroblasts

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12 December 2020

A protein-counting mechanism for telomere length regulation in yeast.

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12 December 2020

Ku is associated with the telomere in mammals

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12 December 2020

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

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12 December 2020

Switching and signaling at the telomere

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12 December 2020

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.

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12 December 2020

Dynamics of telomeric DNA turnover in yeast

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12 December 2020

Short telomeres induce a DNA damage response in Saccharomyces cerevisiae

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12 December 2020

Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways

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12 December 2020

Regulation of tubulin gene expression during embryogenesis in Drosophila melanogaster.

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12 December 2020

Human Ku70/80 associates physically with telomerase through interaction with hTERT

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12 December 2020

Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis

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12 December 2020

An alternative pathway for yeast telomere maintenance rescues est1- senescence

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12 December 2020

Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86

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12 December 2020

Which end: dissecting Ku's function at telomeres and double-strand breaks: Figure 1

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12 December 2020

Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo

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12 December 2020

Regulation of telomerase by telomeric proteins

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12 December 2020

Nonlinear effects in macromolecular assembly and dosage sensitivity

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12 December 2020

Telomere maintenance without telomerase

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12 December 2020

The Rad51 pathway of telomerase-independent maintenance of telomeres can amplify TG1-3 sequences in yku and cdc13 mutants of Saccharomyces cerevisiae.

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12 December 2020

Est1 has the properties of a single-stranded telomere end-binding protein

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12 December 2020

Living with genome instability: plant responses to telomere dysfunction

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12 December 2020

Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span

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12 December 2020

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

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12 December 2020

A molecular switch underlies a human telomerase disease

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12 December 2020

Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae

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12 December 2020

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein

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12 December 2020

Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events

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12 December 2020

Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase

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12 December 2020

Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA

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12 December 2020

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

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12 December 2020

10.1007/S10577-005-0994-5

Identifiers

DOI

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13 August 2017

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