(Q36247797)

English

Transcriptional upregulation of p57 (Kip2) by the cyclin-dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity

scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Transcriptional upregulation of p57 (Kip2) by the cyclin-dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

author name string

Y Ma

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

W D Cress

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

0 references

publication date

18 December 2006

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

26

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

24

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

3532-3540

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210143

0 references

Cyclin-dependent kinase pathways as targets for cancer treatment

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29 June 2018

Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma

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29 June 2018

A role of p73 in mitotic exit.

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29 June 2018

p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation

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29 June 2018

Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

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29 June 2018

Drugging cell cycle kinases in cancer therapy

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29 June 2018

Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism.

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29 June 2018

Clinical anticancer drug development: targeting the cyclin-dependent kinases

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29 June 2018

Transcriptional signature of flavopiridol-induced tumor cell death.

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29 June 2018

Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol

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29 June 2018

Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci.

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29 June 2018

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent

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29 June 2018

Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents

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29 June 2018

Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity

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29 June 2018

Small-molecule cyclin-dependent kinase modulators

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29 June 2018

Novel small molecule cyclin-dependent kinases modulators in human clinical trials

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29 June 2018

Cyclin E ablation in the mouse

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29 June 2018

Identification of a functional glucocorticoid response element in the promoter of the cyclin-dependent kinase inhibitor p57Kip2.

1 reference

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29 June 2018

Regulation of the cyclin D3 promoter by E2F1.

1 reference

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29 June 2018

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia

1 reference

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29 June 2018

Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6.

1 reference

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29 June 2018

Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1.

1 reference

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29 June 2018

Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models

1 reference

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29 June 2018

Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms

1 reference

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29 June 2018

E2Fs regulate adipocyte differentiation

1 reference

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29 June 2018

E2F-3B is a physiological target of cyclin A

1 reference

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29 June 2018

Flavopiridol, a novel cyclin-dependent kinase inhibitor, in clinical development

1 reference

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29 June 2018

Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors

1 reference

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29 June 2018

Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase

1 reference

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29 June 2018

Induction of p57(KIP2) expression by p73beta.

1 reference

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29 June 2018

Identification of novel E2F1-regulated genes by microarray

1 reference

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29 June 2018

Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

1 reference

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29 June 2018

Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

1 reference

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29 June 2018

The Rb/E2F pathway and cancer

1 reference

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29 June 2018

Role of the p53-homologue p73 in E2F1-induced apoptosis

1 reference

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29 June 2018

Role for the p53 homologue p73 in E2F-1-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

Expression of p57(KIP2) potently blocks the growth of human astrocytomas and induces cell senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

Cyclin-dependent kinases as a therapeutic target for stroke.

1 reference

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29 June 2018

A role for E2F1 in Ras activation of p21(WAF1/CIP1) transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

p57Kip2, a glucocorticoid-induced inhibitor of cell cycle progression in HeLa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

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29 June 2018

Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

The Us9 gene product of pseudorabies virus, an alphaherpesvirus, is a phosphorylated, tail-anchored type II membrane protein

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29 June 2018

Use of the E2F transcription factor by DNA tumor virus regulatory proteins.

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29 June 2018

A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.

1 reference

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29 June 2018

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

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29 June 2018

The transcription factor E2F-1 mediates the autoregulation of RB gene expression

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29 June 2018

WAF1, a potential mediator of p53 tumor suppression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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29 June 2018

Interacting domains of E2F1, DP1, and the adenovirus E4 protein

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29 June 2018

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

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29 June 2018

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

G1 phase progression: cycling on cue

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29 June 2018

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

1 reference

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29 June 2018

Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2128050

29 June 2018

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

1 reference

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29 June 2018

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site

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29 June 2018

Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity

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29 June 2018

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc

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29 June 2018

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control

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29 June 2018

E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor

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29 June 2018

Cyclins: wheels within wheels

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29 June 2018

A family of human cdc2-related protein kinases

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29 June 2018

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7 January 2021

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New drugs in cancer therapy, National Tumor Institute, Naples, 17-18 June 2004.

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22 September 2018

E2F4 deficiency promotes drug-induced apoptosis

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22 September 2018

P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats

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22 September 2018

Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation

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22 September 2018

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

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22 September 2018

p21Cip1 nullizygosity increases tumor metastasis in irradiated mice.

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22 September 2018

Proliferation of cancer cells despite CDK2 inhibition.

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22 September 2018

Clinical pharmacology and pharmacogenetics of flavopiridol 1-h i.v. infusion in patients with refractory neoplasms.

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22 September 2018

Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation

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22 September 2018

A pro-apoptotic effect of the CDK inhibitor p57(Kip2) on staurosporine-induced apoptosis in HeLa cells

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22 September 2018

A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer.

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22 September 2018

Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells.

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22 September 2018

E2F-3 accumulation is regulated by polypeptide stability

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22 September 2018

Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression

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22 September 2018

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression

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22 September 2018

Gateways to clinical trials

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21 October 2018

p73β-Mediated Apoptosis Requires p57kip2Induction and IEX-1 Inhibition

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21 January 2018

Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins

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12 December 2020

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An integral membrane green fluorescent protein marker, Us9-GFP, is quantitatively retained in cells during propidium iodide-based cell cycle analysis by flow cytometry

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https://pubmed.ncbi.nlm.nih.gov/17173074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for a p21-E2F interaction during senescence arrest of normal human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17173074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of E2F activity by p21Waf1/Cip1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17173074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17173074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.ONC.1210143

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Dimensions Publication ID

0 references

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Europe PubMed Central

PMC publication ID

13 August 2017

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1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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