(Q36268310)

13 August 2017

1 reference

title

Targeting calcineurin and associated pathways in cardiac hypertrophy and failure (English)

1 reference

13 August 2017

Beate Fiedler

1

1 reference

PubMed ID

16185152

13 August 2017

Kai C Wollert

series ordinal

2

1 reference

PubMed ID

16185152

13 August 2017

language of work or name

English

0 references

publication date

1 October 2005

1 reference

Expert Opinion on Therapeutic Targets

13 August 2017

1 reference

13 August 2017

9

1 reference

13 August 2017

5

1 reference

13 August 2017

963-973

1 reference

Hypertrophy of the heart: a new therapeutic target?

13 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

The cellular and molecular response of cardiac myocytes to mechanical stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Signaling pathways for cardiac hypertrophy and failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Cytoplasmic signaling pathways that regulate cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Sizing up the heart: development redux in disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

A guide for the perplexed: towards an understanding of the molecular basis of heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Toward transcriptional therapies for the failing heart: chemical screens to modulate genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Calcineurin inhibition and cardiac hypertrophy: a matter of balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Calcineurin activates NF-kappaB in skeletal muscle C2C12 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

From calcium to NF-kappa B signaling pathways in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Downregulation of cytoskeletal muscle LIM protein by nitric oxide: impact on cardiac myocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

The SCF ubiquitin ligase: an extended look

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Calcineurin and human heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Isolation of the cyclosporin-sensitive T cell transcription factor NFATp

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Identification of a putative regulator of early T cell activation genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Calcineurin signaling and muscle remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Regulation of cardiac remodeling by nitric oxide: focus on cardiac myocyte hypertrophy and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Putting the brakes on cardiac hypertrophy: exploiting the NO-cGMP counter-regulatory system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Viagra: now mending hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Interactions among ACE, kinins and NO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Effect of ACE inhibitors and angiotensin II type 1 receptor antagonists on endothelial NO synthase knockout mice with heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Identification of ubiquitin ligases required for skeletal muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Cain, a novel physiologic protein inhibitor of calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Association of protein kinase A and protein phosphatase 2B with a common anchoring protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

21 January 2018

The renaissance of GSK3

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.5.963

21 January 2018

Identifiers

DOI

10.1517/14728222.9.5.963

1 reference

13 August 2017

1 reference

PubMed ID

16185152