(Q36274925)

13 August 2017

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title

Regulation of MHC class II gene expression by the class II transactivator (English)

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Salomé Leibundgut-Landmann

13 August 2017

object named as

Salomé LeibundGut-Landmann

series ordinal

2

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Walter Reith

series ordinal

1

object named as

Walter Reith

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13 August 2017

Jean-Marc Waldburger

3

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13 August 2017

1 October 2005

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Nature Reviews Immunology

13 August 2017

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13 August 2017

5

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13 August 2017

793-806

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13 August 2017

10

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Major histocompatibility complex class II deficiency: clinical manifestations, immunologic features, and outcome

13 August 2017

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The bare lymphocyte syndrome and the regulation of MHC expression

31 March 2020

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Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression

31 March 2020

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Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice.

31 March 2020

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MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells.

31 March 2020

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Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene.

31 March 2020

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Genetic control of MHC class II expression

31 March 2020

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Transcriptional regulation of the MHC class II antigen presentation pathway

31 March 2020

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Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes

31 March 2020

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Long distance control of MHC class II expression by multiple distal enhancers regulated by regulatory factor X complex and CIITA.

31 March 2020

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Chromatin remodeling and extragenic transcription at the MHC class II locus control region.

31 March 2020

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Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets

31 March 2020

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aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression

31 March 2020

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Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

31 March 2020

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A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)

31 March 2020

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A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients

31 March 2020

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RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency

31 March 2020

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RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency

31 March 2020

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Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X.

31 March 2020

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CREB regulates MHC class II expression in a CIITA-dependent manner

31 March 2020

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The molecular biology of the CCAAT-binding factor NF-Y

31 March 2020

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The S box of major histocompatibility complex class II promoters is a key determinant for recruitment of the transcriptional co-activator CIITA.

31 March 2020

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Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes

31 March 2020

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CATERPILLER: a novel gene family important in immunity, cell death, and diseases

31 March 2020

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NOD-LRR proteins: role in host-microbial interactions and inflammatory disease

31 March 2020

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The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32

31 March 2020

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Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein

31 March 2020

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CIITA regulates transcription onset viaSer5-phosphorylation of RNA Pol II

31 March 2020

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Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection

31 March 2020

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The class II transactivator requires brahma-related gene 1 to activate transcription of major histocompatibility complex class II genes.

31 March 2020

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Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250

31 March 2020

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Phosphorylation of CIITA directs its oligomerization, accumulation and increased activity on MHCII promoters

31 March 2020

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Phosphorylation of class II transactivator regulates its interaction ability and transactivation function.

31 March 2020

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Serine residues 286, 288, and 293 within the CIITA: a mechanism for down-regulating CIITA activity through phosphorylation

31 March 2020

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Enhancement of CIITA transcriptional function by ubiquitin

31 March 2020

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Promoter IV of the class II transactivator gene is essential for positive selection of CD4+ T cells.

31 March 2020

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Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.

31 March 2020

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Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1

31 March 2020

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Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.

31 March 2020

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Lack of CIITA expression is central to the absence of antigen presentation functions of trophoblast cells and is caused by methylation of the IFN-gamma inducible promoter (PIV) of CIITA.

31 March 2020

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Methylation of class II trans-activator promoter IV: a novel mechanism of MHC class II gene control

31 March 2020

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Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.

31 March 2020

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Active suppression of the class II transactivator-encoding AIR-1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells

31 March 2020

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Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression

31 March 2020

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Regulation of MHC class II expression in human T-cell malignancies

31 March 2020

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DNA alkylating agents alleviate silencing of class II transactivator gene expression in L1210 lymphoma cells

31 March 2020

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Lack of IFN-gamma-mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines

31 March 2020

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Class II transactivator and class II MHC gene expression in microglia: modulation by the cytokines TGF-beta, IL-4, IL-13 and IL-10.

31 March 2020

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Regulation by transforming growth factor-beta1 of class II mRNA and protein expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

31 March 2020

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The Smad3 Protein Is Involved in TGF- Inhibition of Class II Transactivator and Class II MHC Expression

31 March 2020

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Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.

31 March 2020

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Modulation of major histocompatibility class II protein expression by varicella-zoster virus

31 March 2020

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Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway

31 March 2020

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Human parainfluenza virus type 3 inhibits gamma interferon-induced major histocompatibility complex class II expression directly and by inducing alpha/beta interferon

31 March 2020

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Chlamydia inhibits interferon gamma-inducible major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1.

31 March 2020

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Toxoplasma gondii inhibits MHC class II expression in neural antigen-presenting cells by down-regulating the class II transactivator CIITA.

31 March 2020

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Inhibition of IFN-gamma-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion

31 March 2020

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Statins as a newly recognized type of immunomodulator

31 March 2020

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The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

31 March 2020

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The MHC class II transactivator (CIITA) mRNA stability is critical for the HLA class II gene expression in myelomonocytic cells.

31 March 2020

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N-terminal destruction signals lead to rapid degradation of the major histocompatibility complex class II transactivator CIITA.

31 March 2020

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Dendritic cell-specific MHC class II transactivator contains a caspase recruitment domain that confers potent transactivation activity

31 March 2020

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Constitutive expression of MHC class II genes in melanoma cell lines results from the transcription of class II transactivator abnormally initiated from its B cell-specific promoter

31 March 2020

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Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta

31 March 2020

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Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitis

31 March 2020

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Regulation of class II MHC expression in APCs: roles of types I, III, and IV class II transactivator

31 March 2020

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IFN-gamma regulation of class II transactivator promoter IV in macrophages and microglia: involvement of the suppressors of cytokine signaling-1 protein

31 March 2020

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Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-alpha

31 March 2020

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Positive and negative selection of T cells

31 March 2020

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Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC

31 March 2020

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Co-occupancy of the interferon regulatory element of the class II transactivator (CIITA) type IV promoter by interferon regulatory factors 1 and 2.

31 March 2020

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Impaired class II transactivator expression in mice lacking interferon regulatory factor-2.

31 March 2020

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Kinetics of a gamma interferon response: expression and assembly of CIITA promoter IV and inhibition by methylation

31 March 2020

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Differential usage of class II transactivator promoters PI and PIV during inflammation and injury in kidney

31 March 2020

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Interferon-gamma-induced chromatin remodeling at the CIITA locus is BRG1 dependent

31 March 2020

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Class II Transactivator (CIITA) Promoter Methylation Does Not Correlate with Silencing of CIITA Transcription in Trophoblasts1

31 March 2020

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Regulation of major histocompatibility complex class II gene expression in trophoblast cells

31 March 2020

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MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

31 March 2020

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Lymphostromal interactions in thymic development and function

31 March 2020

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Discrimination between maintenance- and differentiation-inducing signals during initial and intermediate stages of positive selection

31 March 2020

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The pIV-otal class II transactivator promoter regulates major histocompatibility complex class II expression in the thymus

31 March 2020

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In vitro models of T cell development

31 March 2020

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Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

31 March 2020

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Immune response in mice that lack the interferon-gamma receptor

31 March 2020

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Thymic generation and regeneration

31 March 2020

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Isolation of a B-cell-specific promoter for the human class II transactivator

31 March 2020

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Plasmacytoid dendritic cells in immunity

31 March 2020

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Deregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4+ T lymphocytes

31 March 2020

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Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III

31 March 2020

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Regulation and specificity of MHC2TA promoter usage in human primary T lymphocytes and cell line

31 March 2020

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A novel element and a TEF-2-like element activate the major histocompatibility complex class II transactivator in B-lymphocytes

31 March 2020

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Transcriptional regulation of the MHC class II trans-activator (CIITA) promoter III: identification of a novel regulatory region in the 5'-untranslated region and an important role for cAMP-responsive element binding protein 1 and activating transcr

31 March 2020

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E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII).

31 March 2020

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MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction

31 March 2020

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BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells

31 March 2020

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Positive regulatory domain I binding factor 1 silences class II transactivator expression in multiple myeloma cells

31 March 2020

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The HLA class II transcriptional activator blocks the function of HIV-1 Tat and inhibits viral replication

31 March 2020

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The MHC class II transcriptional activator (CIITA) inhibits HTLV-2 viral replication by blocking the function of the viral transactivator Tax-2.

31 March 2020

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Tumour immunology, vaccination and escape strategies

31 March 2020

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CD40–CD40Ligand interactions and their role in cytotoxic T lymphocyte priming and anti-tumor immunity

31 March 2020

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Regulation of the expression of MHC class I and II by class II transactivator (CIITA) in hematopoietic cells

31 March 2020

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B-cell lymphomas of high-grade malignancy frequently lack HLA-DR, -DP and -DQ antigens and associated invariant chain.

31 March 2020

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Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma Mol

31 March 2020

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Targeted therapy of solid malignancies via HLA class II antigens: a new biotherapeutic approach?

31 March 2020

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Inactivation of class II transactivator by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon-gamma in haematopoietic tumour cells

31 March 2020

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Immune regulation in multiple myeloma: the host-tumour conflict

31 March 2020

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Regulation of MHC class II expression in glioma cells by class II transactivator (CIITA).

31 March 2020

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Major histocompatibility complex class II expression by intrinsic renal cells is required for crescentic glomerulonephritis

31 March 2020

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A novel anti-inflammatory role for simvastatin in inflammatory arthritis

31 March 2020

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Assessment of the efficacy of different statins in murine collagen-induced arthritis

31 March 2020

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Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial

31 March 2020

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Statins and control of MHC2TA gene transcription

31 March 2020

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Tumor rejection by gene transfer of the MHC class II transactivator in murine mammary adenocarcinoma cells.

31 March 2020

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Generating MHC Class II+/Ii- phenotype after adenoviral delivery of both an expressible gene for MHC Class II inducer and an antisense Ii-RNA construct in tumor cells

31 March 2020

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Presentation of endogenously synthesized MHC class II-restricted epitopes by MHC class II cancer vaccines is independent of transporter associated with Ag processing and the proteasome.

31 March 2020

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Curative antitumor immune response is optimal with tumor irradiation followed by genetic induction of major histocompatibility complex class I and class II molecules and suppression of Ii protein

31 March 2020

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Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells

31 March 2020

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HLA class II antibodies in the treatment of hematologic malignancies

31 March 2020

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Induction of MHC class I expression by the MHC class II transactivator CIITA.

31 March 2020

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Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA

31 March 2020

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CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions.

31 March 2020

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Modulation of gene expression by the MHC class II transactivator

31 March 2020

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A 36-amino-acid region of CIITA is an effective inhibitor of CBP: novel mechanism of gamma interferon-mediated suppression of collagen alpha(2)(I) and other promoters

31 March 2020

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Cathepsin E: a novel target for regulation by class II transactivator

31 March 2020

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Aberrant expression of Fas ligand in mice deficient for the MHC class II transactivator

31 March 2020

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MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300.

31 March 2020

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T cell expression of CIITA represses Th1 immunity.

31 March 2020

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Escape of human cytomegalovirus from HLA-DR-restricted CD4(+) T-cell response is mediated by repression of gamma interferon-induced class II transactivator expression

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1708

1 reference

13 August 2017

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PubMed ID

16200082