(Q36281273)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10548068%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Incorporation of noncoded amino acids into the N-terminal domain 1-47 of hirudin yields a highly potent and selective thrombin inhibitor (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10548068%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

2

1 reference

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1 November 2019

author name string

V De Filippis

1

1 reference

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1 November 2019

A Vindigni

3

1 reference

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1 November 2019

E Di Cera

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10548068%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

S Salmaso

5

1 reference

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1 November 2019

A Fontana

6

1 reference

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1 November 2019

publication date

1 October 1999

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1 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10548068%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

volume

8

1 reference

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1 November 2019

issue

10

1 reference

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1 November 2019

page(s)

2213-2217

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10548068%20AND%20SRC:MED&resulttype=core&format=json

Thrombin and antithrombotics

1 November 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Novastan (brand of argatroban): a small-molecule, direct thrombin inhibitor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Site-specific dissection of substrate recognition by thrombin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

NMR solution structure of a novel hirudin variant HM2, N-terminal 1-47 and N64-->V + G mutant

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

The development of hirudin as an antithrombotic drug

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Novel hirudin variants from the leech Hirudinaria manillensis. Amino acid sequence, cDNA cloning and genomic organization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Thrombin active site inhibitors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Conformation of recombinant desulfatohirudin in aqueous solution determined by nuclear magnetic resonance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Production, properties, and thrombin inhibitory mechanism of hirudin amino-terminal core fragments.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

The coagulation cascade: initiation, maintenance, and regulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Refined structure of the hirudin-thrombin complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Pharmacologic Aspects of the Development of Selective Synthetic Thrombin Inhibitors as Anticoagulants

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Thrombin inhibitor design.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Hirudin and hirudin analogues as new anticoagulant agents

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Probing the conformational state of apomyoglobin by limited proteolysis.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Interaction of the N-terminal region of hirudin with the active-site cleft of thrombin

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

16 The interpretation of near-ultraviolet circular dichroism

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

29 June 2018

Anticoagulant thrombins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Site-specific analysis of mutational effects in proteins.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144148

Probing the structure of hirudin from Hirudinaria manillensis by limited proteolysis. Isolation, characterization and thrombin-inhibitory properties of N-terminal fragments

22 September 2018

1 reference

12 December 2020

Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids

1 reference

12 December 2020

Determination of protein secondary structure in solution by vacuum ultraviolet circular dichroism

1 reference

12 December 2020

Molecular recognition by thrombin. Role of the slow-->fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components

1 reference

12 December 2020

Comparative pharmacology of site directed antithrombin agents. Implication in drug development

1 reference

12 December 2020

Direct thrombin inhibitors: appraisal of the antithrombotic/hemorrhagic balance

1 reference

12 December 2020

Core domain of hirudin from the leech Hirudinaria manillensis: chemical synthesis, purification, and characterization of a Trp3 analog of fragment 1-47

1 reference

12 December 2020

Identifiers

DOI

10.1110/PS.8.10.2213

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10548068%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10548068%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

PubMed publication ID

10548068

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10548068%20AND%20SRC:MED&resulttype=core&format=json