(Q48007250)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9615169%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

review article

1 reference

title

Site-specific analysis of mutational effects in proteins (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9615169%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

author name string

E di Cera

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9615169%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

publication date

1 January 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9615169%20AND%20SRC:MED&resulttype=core&format=json

Advances in Protein Chemistry

12 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9615169%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

volume

51

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9615169%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

page(s)

59-119

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9615169%20AND%20SRC:MED&resulttype=core&format=json

Effects of site-specific amino acid modification on protein interactions and biological function

12 November 2019

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7 January 2021

Molecular recognition by thrombin. Role of the slow-->fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components

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7 January 2021

Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species

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7 January 2021

Multiple-site titration curves of proteins: an analysis of exact and approximate methods for their calculation

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7 January 2021

Enhanced protein C activation and inhibition of fibrinogen cleavage by a thrombin modulator

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7 January 2021

Ionic interactions in the formation of the thrombin-hirudin complex

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7 January 2021

The Mechanism of Action of Methionyl-tRNA Synthetase from Escherichia coli. Inhibition by Adenosine and 8-Aminoadenosine of the Amino-Acid Activation Reaction

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7 January 2021

The N-Terminal Disulphide Knot of Human Fibrinogen

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7 January 2021

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

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7 January 2021

Human alpha- to zeta-thrombin cleavage occurs with neutrophil cathepsin G or chymotrypsin while fibrinogen clotting activity is retained

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7 January 2021

Dissecting the catalytic triad of a serine protease

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7 January 2021

The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)

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7 January 2021

Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin.

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7 January 2021

A hot spot of binding energy in a hormone-receptor interface

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7 January 2021

Redesigning trypsin: alteration of substrate specificity

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7 January 2021

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7 January 2021

High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

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7 January 2021

Peptides on phage: a vast library of peptides for identifying ligands

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7 January 2021

Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases

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7 January 2021

An allosteric switch controls the procoagulant and anticoagulant activities of thrombin

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7 January 2021

Rational engineering of activity and specificity in a serine protease

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7 January 2021

Selective loss of fibrinogen clotting in a loop-less thrombin

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7 January 2021

The coagulation cascade: initiation, maintenance, and regulation

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7 January 2021

Core domain of hirudin from the leech Hirudinaria manillensis: chemical synthesis, purification, and characterization of a Trp3 analog of fragment 1-47

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7 January 2021

Random peptide libraries: a source of specific protein binding molecules

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7 January 2021

The Na+ binding site of thrombin

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7 January 2021

Molecular mechanisms of thrombin function

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7 January 2021

Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa

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7 January 2021

Dominant forces in protein folding

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7 January 2021

Origins of the specificity of tissue-type plasminogen activator

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7 January 2021

Reconstructing the evolution of vertebrate blood coagulation from a consideration of the amino acid sequences of clotting proteins

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7 January 2021

Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

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7 January 2021

Characterization of a cDNA coding for human protein C

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https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Factor XI activation in a revised model of blood coagulation

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https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Experimental measurement of the effective dielectric in the hydrophobic core of a protein.

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7 January 2021

Conversion of thrombin into an anticoagulant by protein engineering

1 reference

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7 January 2021

Multiple-site titration and molecular modeling: two rapid methods for computing energies and forces for ionizable groups in proteins

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7 January 2021

Cellular consequences of thrombin-receptor activation

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7 January 2021

Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease

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7 January 2021

Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state.

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7 January 2021

Tipping the balance of blood coagulation

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7 January 2021

Critical role of W60d in thrombin allostery

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7 January 2021

Identification of residues linked to the slow-->fast transition of thrombin

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7 January 2021

Characterization of a cDNA coding for human factor VII

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7 January 2021

Converting trypsin to chymotrypsin: the role of surface loops

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7 January 2021

Enzymatic properties of proteolytic derivatives of human alpha-thrombin

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7 January 2021

On the active site topography of isoleucyl transfer ribonucleic acid synthetase of Escherichia coli B.

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7 January 2021

Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins

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7 January 2021

Co-operative interactions during protein folding.

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7 January 2021

A second-site mutation at phenylalanine-137 that increases catalytic efficiency in the mutant aspartate-27----serine Escherichia coli dihydrofolate reductase.

1 reference

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7 January 2021

Protease-activated receptor 3 is a second thrombin receptor in humans

1 reference

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7 January 2021

Contribution of long-range electrostatic interactions to the stabilization of the catalytic transition state of the serine protease subtilisin BPN'

1 reference

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7 January 2021

On the attribution and additivity of binding energies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Probing the mechanism of staphylococcal nuclease with unnatural amino acids: kinetic and structural studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Transition modes in Ising networks: an approximate theory for macromolecular recognition

1 reference

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7 January 2021

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Conserved water molecules in the specificity pocket of serine proteases and the molecular mechanism of Na+ binding

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Conversion of allosteric inhibition to activation in phosphofructokinase by protein engineering.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Conservation and variability in the structures of serine proteinases of the chymotrypsin family

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Long-range, small magnitude nonadditivity of mutational effects in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Direct and indirect pathways of functional coupling in human hemoglobin are revealed by quantitative low-temperature isoelectric focusing of mutant hybrids

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Evaluating the effects of a single amino acid substitution on both the native and denatured states of a protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

The action of thrombin on peptide p-nitroanilide substrates. Substrate selectivity and examination of hydrolysis under different reaction conditions

1 reference

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7 January 2021

Cofactor proteins in the assembly and expression of blood clotting enzyme complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

The 2.8 A crystal structure of Gla-domainless activated protein C

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7 January 2021

Structural and genetic analysis of protein stability

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Contributions of the ionizable amino acids to the stability of staphylococcal nuclease.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Quantitative interpretations of double mutations of enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Protein stability effects of a complete set of alanine substitutions in Arc repressor

1 reference

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7 January 2021

Prothrombin Salakta: substitution of glutamic acid-466 by alanine reduces the fibrinogen clotting activity and the esterase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Allosteric proteins and cellular control systems

1 reference

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7 January 2021

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

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7 January 2021

Dissociation constants and structures of glutamic acid and its esters

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7 January 2021

Evolution of Proteolytic Enzymes

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7 January 2021

Solution structure of a platelet receptor peptide bound to bovine alpha-thrombin

1 reference

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7 January 2021

Structure of human des(1-45) factor Xa at 2.2 A resolution

1 reference

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7 January 2021

Structural basis of substrate specificity in the serine proteases

1 reference

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7 January 2021

Relocating a negative charge in the binding pocket of trypsin

1 reference

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7 January 2021

Long-range electrostatic interactions can influence the folding, stability, and cooperativity of dihydrofolate reductase.

1 reference

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7 January 2021

Evolutionary families of peptidases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Tryptophan 60-D in the B-insertion loop of thrombin modulates the thrombin-antithrombin reaction

1 reference

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7 January 2021

Contribution of lysine 60f to S1' specificity of thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Mutants of rat intestinal fatty acid-binding protein illustrate the critical role played by enthalpy-entropy compensation in ligand binding

1 reference

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7 January 2021

Electrostatic stabilization in four-helix bundle proteins

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7 January 2021

Refined structure of the hirudin-thrombin complex

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7 January 2021

Influence of interior packing and hydrophobicity on the stability of a protein.

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7 January 2021

On the size of the active site in proteases. I. Papain

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7 January 2021

A simple model for solvation in mixed solvents. Applications to the stabilization and destabilization of macromolecular structures

1 reference

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7 January 2021

Searching for Peptide Ligands with an Epitope Library

1 reference

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7 January 2021

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

The denatured state (the other half of the folding equation) and its role in protein stability.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation

1 reference

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7 January 2021

Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

1 reference

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

1 reference

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

1 reference

7 January 2021

Site-directed isotope labelling and FTIR spectroscopy of bacteriorhodopsin

1 reference

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7 January 2021

New tool for spectroscopists

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Warfarin-induced changes in procoagulant and anticoagulant proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Mechanism of action of enolase: effect of the beta-hydroxy group on the rate of dissociation of the alpha-carbon-hydrogen bond

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

The interaction of thrombin with fibrinogen. A structural basis for its specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Amino acid sequence studies on factor XIII and the peptide released during its activation by thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

1 reference

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7 January 2021

Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Release of fibrinopeptides by the slow and fast forms of thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Site-specific dissection of substrate recognition by thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Energetics of thrombin-thrombomodulin interaction.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Contribution of the N-terminal region of hirudin to its interaction with thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Systematic derivation of partition functions for ligand binding to two-dimensional lattices

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

How do serine proteases really work?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Thrombin is a Na(+)-activated enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Additivity of mutational effects in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

1 reference

7 January 2021

Small peptides as potent mimetics of the protein hormone erythropoietin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

LINKED FUNCTIONS AND RECIPROCAL EFFECTS IN HEMOGLOBIN: A SECOND LOOK.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

On the calculation of pKas in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Characterization of the receptor binding determinants of granulocyte colony stimulating factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

The molecular environment of the Na+ binding site of thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Stability of proteins: small globular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

Energetics of Ligand Binding to Proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-3233%2808%2960651-8

1 reference

7 January 2021

10.1016/S0065-3233(08)60651-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9615169%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference