(Q36282901)

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Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation

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Europe PubMed Central

PMC publication ID

13 August 2017

Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation (English)

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Europe PubMed Central

PMC publication ID

13 August 2017

phosphorylation

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J. Andrew McCammon

8

object named as

J Andrew McCammon

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Europe PubMed Central

PMC publication ID

13 August 2017

author name string

Yuanhua Cheng

1

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Europe PubMed Central

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13 August 2017

Vijay Rao

2

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Europe PubMed Central

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13 August 2017

An-Yue Tu

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Steffen Lindert

4

1 reference

Europe PubMed Central

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13 August 2017

Dan Wang

5

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Lucas Oxenford

6

1 reference

Europe PubMed Central

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13 August 2017

Andrew D McCulloch

7

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Europe PubMed Central

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13 August 2017

Michael Regnier

9

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13 August 2017

language of work or name

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publication date

21 September 2015

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Europe PubMed Central

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13 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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13 August 2017

290

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Europe PubMed Central

PMC publication ID

13 August 2017

46

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

27749-27766

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

The R21C Mutation in Cardiac Troponin I Imposes Differences in Contractile Force Generation between the Left and Right Ventricles of Knock-In Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Effects of HCM cTnI mutation R145G on troponin structure and modulation by PKA phosphorylation elucidated by molecular dynamics simulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Ca(2+)-regulatory function of the inhibitory peptide region of cardiac troponin I is aided by the C-terminus of cardiac troponin T: Effects of familial hypertrophic cardiomyopathy mutations cTnI R145G and cTnT R278C, alone and in combination, on fil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca(2+)-desensitizing variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Structural and kinetic effects of hypertrophic cardiomyopathy related mutations R146G/Q and R163W on the regulatory switching activity of rat cardiac troponin I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal history

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Sites of intra- and intermolecular cross-linking of the N-terminal extension of troponin I in human cardiac whole troponin complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Protein kinase A-mediated phosphorylation of cMyBP-C increases proximity of myosin heads to actin in resting myocardium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Role of the acidic N' region of cardiac troponin I in regulating myocardial function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Gene mutations in apical hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Scalable molecular dynamics with NAMD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Sarcomeric determinants of striated muscle relaxation kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Cardiac length dependence of force and force redevelopment kinetics with altered cross-bridge cycling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Relaxation kinetics following sudden Ca(2+) reduction in single myofibrils from skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Myofilament calcium sensitivity and cardiac disease: insights from troponin I isoforms and mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Effects of T142 phosphorylation and mutation R145G on the interaction of the inhibitory region of human cardiac troponin I with the C-domain of human cardiac troponin C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Development and current status of the CHARMM force field for nucleic acids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Ca2+ - and cross-bridge-dependent changes in N- and C-terminal structure of troponin C in rat cardiac muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

The effect of inorganic phosphate on force generation in single myofibrils from rabbit skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Regulation of contraction in striated muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Calcium-induced structural transition in the regulatory domain of human cardiac troponin C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Active and passive forces of isolated myofibrils from cardiac and fast skeletal muscle of the frog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

VMD: visual molecular dynamics

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

Rate of force generation in muscle: correlation with actomyosin ATPase activity in solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

30 September 2017

In vivo and in vitro analysis of cardiac troponin I phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

29 June 2018

Stepwise subunit interaction changes by mono- and bisphosphorylation of cardiac troponin I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

29 June 2018

N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

A mutation in the N-terminus of troponin I that is associated with hypertrophic cardiomyopathy affects the Ca(2+)-sensitivity, phosphorylation kinetics and proteolytic susceptibility of troponin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Myofibrillar determinants of rate of relaxation in skinned skeletal muscle fibers.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.

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22 September 2018

Small-angle neutron scattering with contrast variation reveals spatial relationships between the three subunits in the ternary cardiac troponin complex and the effects of troponin I phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Functional analysis of a troponin I (R145G) mutation associated with familial hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Effects of phosphorylation and mutation R145G on human cardiac troponin I function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Phosphorylation-induced distance change in a cardiac muscle troponin I mutant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Preparation of troponin and its subunits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Rapid 'give' and the tension 'shoulder' in the relaxation of frog muscle fibres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646022

22 September 2018

Comparison of simple potential functions for simulating liquid water

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.683045

21 January 2018

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.683045

21 January 2018

2-Deoxy-ATP Enhances Contractility of Rat Cardiac Muscle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.683045

21 January 2018

Structural mapping of single cysteine mutants of cardiac troponin I

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+-induced conformational transition in the inhibitory and regulatory regions of cardiac troponin I

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some precautions in using chelators to buffer metals in biological solutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural changes during activation of frog muscle studied by time-resolved X-ray diffraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reconstitution of skinned cardiac fibres with human recombinant cardiac troponin-I mutants and troponin-C

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fourth EF-hand of calmodulin and its helix-loop-helix components: impact on calcium binding and enzyme activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of protein kinase A phosphorylation on signaling between cardiac troponin I and the N-terminal domain of cardiac troponin C

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of troponin-C interactions in skinned barnacle muscle: comparison with troponin-C from rabbit striated muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMR analysis of cardiac troponin C-troponin I complexes: effects of phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thin filament Ca2+ binding properties and regulatory unit interactions alter kinetics of tension development and relaxation in rabbit skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/26391394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M115.683045

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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