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Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592
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Europe PubMed Central
PMCID
4646291
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
title
Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592
(English)
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stated in
Europe PubMed Central
PMCID
4646291
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
main subject
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
1 reference
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GOA release 2020-03-11
defense response to virus
1 reference
stated in
GOA release 2020-03-11
author
Li Wu
series ordinal
3
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Europe PubMed Central
PMCID
4646291
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
author name string
Chenxiang Tang
series ordinal
1
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Europe PubMed Central
PMCID
4646291
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
Xiaoyun Ji
series ordinal
2
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stated in
Europe PubMed Central
PMCID
4646291
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
Yong Xiong
series ordinal
4
1 reference
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Europe PubMed Central
PMCID
4646291
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
language of work or name
English
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publication date
20 August 2015
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stated in
Europe PubMed Central
PMCID
4646291
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
published in
Journal of Biological Chemistry
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Europe PubMed Central
PMCID
4646291
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retrieved
22 February 2020
volume
290
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Europe PubMed Central
PMCID
4646291
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22 February 2020
page(s)
26352-26359
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Europe PubMed Central
PMCID
4646291
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
issue
44
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stated in
Europe PubMed Central
PMCID
4646291
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
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SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity
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PubMed Central
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CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain
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The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
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Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells
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GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state
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SAMHD1 prevents autoimmunity by maintaining genome stability
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SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.
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Mechanism of allosteric activation of SAMHD1 by dGTP
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SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.
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Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1.
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Deoxynucleoside triphosphate (dNTP) synthesis and destruction regulate the replication of both cell and virus genomes.
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GTP is the primary activator of the anti-HIV restriction factor SAMHD1.
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The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.
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Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells
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Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.
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The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation
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Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection
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SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons
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SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells
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SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations
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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
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Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype
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30 September 2017
SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection
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30 September 2017
Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase
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30 September 2017
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
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30 September 2017
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
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30 September 2017
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response
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Phasercrystallographic software
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Cyclin-dependent kinases: engines, clocks, and microprocessors
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The role of the alpha-helix dipole in protein function and structure
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Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 A
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30 September 2017
Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity
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retrieved
29 June 2018
Identifiers
DOI
10.1074/JBC.M115.677435
1 reference
stated in
Europe PubMed Central
PMCID
4646291
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
PMCID
4646291
1 reference
stated in
Europe PubMed Central
PMCID
4646291
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
PubMed ID
26294762
1 reference
stated in
Europe PubMed Central
PMCID
4646291
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
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