(Q36287487)

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The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection

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Europe PubMed Central

PubMed publication ID

13 August 2017

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Europe PubMed Central

The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection (English)

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Europe PubMed Central

PubMed publication ID

13 August 2017

2

object named as

Emil R Unanue

1 reference

Europe PubMed Central

PubMed publication ID

13 August 2017

author name string

Anish Suri

1

1 reference

Europe PubMed Central

PubMed publication ID

13 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 January 2005

1 reference

Europe PubMed Central

PubMed publication ID

13 August 2017

Advances in Immunology

1 reference

Europe PubMed Central

PubMed publication ID

13 August 2017

88

1 reference

Europe PubMed Central

PubMed publication ID

13 August 2017

235-265

1 reference

Europe PubMed Central

PubMed publication ID

13 August 2017

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The MHC class II molecule I-Ag7 exists in alternate conformations that are peptide dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Adrenalitis in the non-obese diabetic mouse

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nonobese diabetic mice display elevated levels of class II-associated invariant chain peptide associated with I-Ag7 on the cell surface

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic Analysis of Autoimmune Sialadenitis in Nonobese Diabetic Mice: A Major Susceptibility Region on Chromosome 1

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Spontaneous autoimmune thyroiditis in NOD.H-2h4 mice

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The lack of consensus for I-A(g7)-peptide binding motifs: is there a requirement for anchor amino acid side chains?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Two structural states of complexes of peptide and class II major histocompatibility complex revealed by photoaffinity-labeled peptides

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

T cell receptor recognition of MHC class II-bound peptide flanking residues enhances immunogenicity and results in altered TCR V region usage

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of immunogenic epitopes of GAD 65 presented by Ag7 in non-obese diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Self-peptides bound to the type I diabetes associated class II MHC molecules HLA-DQ1 and HLA-DQ8.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Insights into antigen processing gained by direct analysis of the naturally processed class I MHC associated peptide repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of I-Ak in complex with a dominant epitope of lysozyme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The motif for peptide binding to the insulin-dependent diabetes mellitus-associated class II MHC molecule I-Ag7 validated by phage display library

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of peptides from autoantigens GAD65 and IA-2 that bind to HLA class II molecules predisposing to or protecting from type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

pH-dependent peptide binding properties of the type I diabetes-associated I-Ag7 molecule: rapid release of CLIP at an endosomal pH.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a putative motif for binding of peptides to HLA-DQ2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of I-Ag7 beta chain in peptide binding and antigen recognition by T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Thymic and postthymic regulation of diabetogenic CD8 T cell development in TCR transgenic nonobese diabetic (NOD) mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Following a diabetogenic T cell from genesis through pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A defect in central tolerance in NOD mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms and consequences of peptide selection by the I-Ak class II molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A comprehensive guide to antibody and T-cell responses in type 1 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic lesions in T-cell tolerance and thresholds for autoimmunity.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Selection of antigen-specific T cells by a single IEk peptide combination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The non-obese diabetic (NOD) mouse: an animal model for autoimmune thyroiditis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

CD4+CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Peptide analysis, stability studies, and structural modeling explain contradictory peptide motifs and unique properties of the NOD mouse MHC class II molecule H2-A(g7).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of an I-Ag7-expressing antigen-presenting cell line: intrinsic molecular defect in compact I-Ag7 dimer generation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of two distinct properties of class II major histocompatibility complex-associated peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevention of autoimmune insulitis by expression of I–E molecules in NOD mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential binding of peptides substituted at a putative C-terminal anchor residue to I-Ag7beta56Hisbeta57Ser and I-Ag7beta56Probeta57Asp

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential binding of peptides substituted at putative C-terminal anchor residue to HLA-DQ8 and DQ9 differing only at beta 57.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct recognition by two subsets of T cells of an MHC class II-peptide complex

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

MHC ligands and peptide motifs: first listing

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Biochemical characterization of the human diabetes-associated HLA-DQ8 allelic product: similarity to the major histocompatibility complex class II I-A(g)7 protein of non-obese diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Non-obese diabetic (NOD) mice are genetically susceptible to experimental autoimmune prostatitis (EAP).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for peptide in determining MHC class II structure

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A mechanism for the major histocompatibility complex-linked resistance to autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevention of diabetes in NOD mice by a mutated I-Ab transgene.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevention of diabetes in non-obese diabetic I-Ak transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of an HLA-DQ2 peptide binding motif and HLA-DPw3-bound self-peptide by pool sequencing

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic control of autoimmune diabetes in the NOD mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective central tolerance induction in NOD mice: genomics and genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2805%2988007-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0065-2776(05)88007-1

1 reference

Europe PubMed Central

PubMed publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 August 2017

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