(Q36288580)

13 August 2017

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title

Structure and mechanism of DNA polymerases (English)

1 reference

13 August 2017

Paul J Rothwell

1

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13 August 2017

Gabriel Waksman

series ordinal

2

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13 August 2017

publication date

1 January 2005

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Advances in Protein Chemistry

13 August 2017

published in

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13 August 2017

volume

71

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13 August 2017

page(s)

401-440

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Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme

13 August 2017

cites work

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DNA polymerase beta: structure-fidelity relationship from Pre-steady-state kinetic analyses of all possible correct and incorrect base pairs for wild type and R283A mutant

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Dependence of DNA polymerase replication rate on external forces: a model based on molecular dynamics simulations

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7 January 2021

Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment).

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Identification and amino acid sequence of the deoxynucleoside triphosphate binding site in Escherichia coli DNA polymerase I.

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7 January 2021

Structure of DNA polymerase I Klenow fragment bound to duplex DNA

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7 January 2021

Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate

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7 January 2021

Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta

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7 January 2021

Compilation, alignment, and phylogenetic relationships of DNA polymerases

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7 January 2021

On molecular mechanisms of nucleic acid synthesis. Fidelity aspects: 2. Contribution of protein-nucleotide recognition

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7 January 2021

Eukaryotic DNA polymerases: proposal for a revised nomenclature.

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7 January 2021

A heterodimeric DNA polymerase: evidence that members of Euryarchaeota possess a distinct DNA polymerase

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7 January 2021

Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4

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7 January 2021

A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity

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7 January 2021

Kinetic mechanism of DNA polymerase I(Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant

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7 January 2021

The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus

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7 January 2021

An attempt to unify the structure of polymerases

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7 January 2021

Repair of abasic sites in DNA.

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7 January 2021

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

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7 January 2021

Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

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7 January 2021

Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution

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7 January 2021

Dimerization kinetics of HIV-1 and HIV-2 reverse transcriptase: a two step process

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7 January 2021

Conformational stability of dimeric HIV-1 and HIV-2 reverse transcriptases

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7 January 2021

DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells

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7 January 2021

Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction

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7 January 2021

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

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7 January 2021

Use of 2-aminopurine and tryptophan fluorescence as probes in kinetic analyses of DNA polymerase beta

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7 January 2021

Fidelity mechanisms in DNA replication

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7 January 2021

Minimal kinetic mechanism for misincorporation by DNA polymerase I (Klenow fragment)

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Structure of Taq polymerase with DNA at the polymerase active site

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7 January 2021

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA polymerase IV.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Pre-steady-state kinetic studies of the fidelity of Sulfolobus solfataricus P2 DNA polymerase IV.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Structure of the replicating complex of a pol alpha family DNA polymerase

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7 January 2021

Cocrystal structure of an editing complex of Klenow fragment with DNA

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase.

1 reference

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7 January 2021

The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidance

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7 January 2021

Novel DNA polymerases offer clues to the molecular basis of mutagenesis

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis

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7 January 2021

Sloppier copier DNA polymerases involved in genome repair

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7 January 2021

HIV-1 reverse transcription: a brief overview focused on structure-function relationships among molecules involved in initiation of the reaction

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7 January 2021

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

A model for the mechanism of polymerase translocation

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7 January 2021

Crystal structure of DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1

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7 January 2021

Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site

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7 January 2021

Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius

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7 January 2021

Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

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7 January 2021

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Compilation and alignment of DNA polymerase sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Dynamics of gapped DNA recognition by human polymerase beta

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Energetics and specificity of Rat DNA polymerase beta interactions with template-primer and gapped DNA substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Interactions of the 8-kDa domain of rat DNA polymerase beta with DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Bridging the gap: a family of novel DNA polymerases that replicate faulty DNA.

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Function and structure relationships in DNA polymerases

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machine

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Temperature-dependent equilibrium between the open and closed conformation of the p66 subunit of HIV-1 reverse transcriptase revealed by site-directed spin labelling.

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Rapid segmental and subdomain motions of DNA polymerase beta.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structure of Thermus aquaticus DNA polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Proteolytic cleavage of DNA polymerase from Escherichia Coli B into an exonuclease unit and a polymerase unit

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

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7 January 2021

Enzymic synthesis of deoxyribonucleic acid

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7 January 2021

Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-A resolution: structural basis for thermostability

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential

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7 January 2021

DNA polymerase beta: analysis of the contributions of tyrosine-271 and asparagine-279 to substrate specificity and fidelity of DNA replication by pre-steady-state kinetics

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

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7 January 2021

Kinetic mechanism of DNA polymerase I (Klenow).

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7 January 2021

Identification and properties of the catalytic domain of mammalian DNA polymerase beta

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7 January 2021

ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. V. CHEMICAL COMPOSITION OF ENZYMATICALLY SYNTHESIZED DEOXYRIBONUCLEIC ACID.

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7 January 2021

Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7.

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7 January 2021

Crystal structures of the Klenow fragment of Thermus aquaticus DNA polymerase I complexed with deoxyribonucleoside triphosphates

1 reference

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7 January 2021

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

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7 January 2021

Crystal structures of a ddATP-, ddTTP-, ddCTP, and ddGTP- trapped ternary complex of Klentaq1: insights into nucleotide incorporation and selectivity

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7 January 2021

Replication of a cis-syn thymine dimer at atomic resolution

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7 January 2021

Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication

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7 January 2021

Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase

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7 January 2021

Fidelity of DNA synthesis

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7 January 2021

Closing of the fingers domain generates motor forces in the HIV reverse transcriptase

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7 January 2021

Major subdomain rearrangement in HIV-1 reverse transcriptase simulated by molecular dynamics

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7 January 2021

Replication by a single DNA polymerase of a stretched single-stranded DNA

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7 January 2021

Genetic identification and nucleotide sequence of the DNA polymerase gene of African swine fever virus.

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Repair of a synthetic abasic site involves concerted reactions of DNA synthesis followed by excision and ligation

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Yeast open reading frame YCR14C encodes a DNA beta-polymerase-like enzyme

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Use of 2-aminopurine fluorescence to examine conformational changes during nucleotide incorporation by DNA polymerase I (Klenow fragment).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Human DNA polymerase beta recognizes single-stranded DNA using two different binding modes

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Recognition of template-primer and gapped DNA substrates by the human DNA polymerase beta

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors.

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

High resolution structures of HIV-1 RT from four RT-inhibitor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7

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7 January 2021

Multiparameter single-molecule fluorescence spectroscopy reveals heterogeneity of HIV-1 reverse transcriptase:primer/template complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal Structures of Human DNA Polymerase β Complexed with Gapped and Nicked DNA: Evidence for an Induced Fit Mechanism,

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

The fidelity of base selection by the polymerase subunit of DNA polymerase III holoenzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

A unified polymerase mechanism for nonhomologous DNA and RNA polymerases

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

A mechanism for all polymerases

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Autogenous translational operator recognized by bacteriophage T4 DNA polymerase

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

A novel DNA polymerase in the hyperthermophilic archaeon, Pyrococcus furiosus: gene cloning, expression, and characterization

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7 January 2021

Crystal structure of the catalytic core of human DNA polymerase kappa

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change

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7 January 2021

Evolution of RNA-binding Specificity in T4 DNA Polymerase

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69

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7 January 2021

Yeast DNA polymerase eta utilizes an induced-fit mechanism of nucleotide incorporation

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7 January 2021

Genetical Implications of the Structure of Deoxyribonucleic Acid

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7 January 2021

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

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7 January 2021

DNA polymerase beta: pre-steady-state kinetic analysis and roles of arginine-283 in catalysis and fidelity.

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7 January 2021

Refined model for primer/template binding by HIV-1 reverse transcriptase: pre-steady-state kinetic analyses of primer/template binding and nucleotide incorporation events distinguish between different binding modes depending on the nature of the nuc

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7 January 2021

An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics

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7 January 2021

A plethora of lesion-replicating DNA polymerases

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7 January 2021

Single-molecule studies of the effect of template tension on T7 DNA polymerase activity.

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Correlation of the kinetics of finger domain mutants in RB69 DNA polymerase with its structure

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se.

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7 January 2021

Damage repair DNA polymerases Y.

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structure of an archaebacterial DNA polymerase

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

DNA polymerase beta: multiple conformational changes in the mechanism of catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

Crystal structure of a DinB lesion bypass DNA polymerase catalytic fragment reveals a classic polymerase catalytic domain

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https://api.crossref.org/works/10.1016%2FS0065-3233%2804%2971011-6

7 January 2021

10.1016/S0065-3233(04)71011-6

Identifiers

DOI

1 reference

13 August 2017

1 reference