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What role can chemistry play in cationic liposome-based gene therapy research today?
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Europe PubMed Central
PubMed publication ID
16240991
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16240991%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
review article
1 reference
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Europe PubMed Central
title
What role can chemistry play in cationic liposome-based gene therapy research today?
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16240991
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16240991%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
main subject
gene therapy
0 references
author
Kostas Kostarelos
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16240991
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16240991%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
author name string
Andrew D Miller
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16240991
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16240991%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
publication date
1 January 2005
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16240991
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16240991%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
published in
Advances in Genetics
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16240991
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16240991%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
volume
53
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16240991
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16240991%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
page(s)
71-118
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16240991
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16240991%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
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Acid-Triggered Release from Sterically Stabilized Fusogenic Liposomes via a Hydrolytic DePEGylation Strategy†
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7 January 2021
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Structure and function of lipid-DNA complexes for gene delivery
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Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization
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Liposomes enhance delivery and expression of an RGD-oligolysine gene transfer vector in human tracheal cells.
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Cell delivery, intracellular trafficking and expression of an integrin-mediated gene transfer vector in tracheal epithelial cells
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Kinetic analysis of the initial steps involved in lipoplex--cell interactions: effect of various factors that influence transfection activity.
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Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin
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Efficient gene transfer by transferrin lipoplexes in the presence of serum
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7 January 2021
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Enhanced gene delivery in vitro and in vivo by improved transferrin-lipoplexes
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7 January 2021
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High-efficiency gene transfection of macrophages by lipoplexes
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7 January 2021
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Current status of pH-sensitive liposomes in drug delivery
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7 January 2021
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Biophysical characterization of cationic lipid: DNA complexes
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7 January 2021
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Synergy between cationic lipid and co-lipid determines the macroscopic structure and transfection activity of lipoplexes
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Endothelial cell transfection with cationic liposomes and herpes simplex-thymidine kinase mediated killing.
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7 January 2021
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Gene transfer into mammalian cells using histone-condensed plasmid DNA.
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7 January 2021
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Potentiation of cationic liposome-mediated gene delivery by polycations
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Mode of formation and structural features of DNA-cationic liposome complexes used for transfection
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Improved preparation of PEG-diortho ester-diacyl glycerol conjugates
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Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid
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Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG--diortho ester--lipid conjugate
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Chemical approaches to triggerable lipid vesicles for drug and gene delivery
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Complexes between cationic liposomes and DNA visualized by cryo-TEM.
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Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
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Folate-targeted gene transfer in vivo
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Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery
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The role of helper lipids in cationic liposome-mediated gene transfer
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Pyridinium cationic lipids in gene delivery: a structure-activity correlation study
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An integrin-targeted non-viral vector for pulmonary gene therapy
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7 January 2021
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Enhancement of gene transfer to cervical cancer cells using transferrin-conjugated liposome
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7 January 2021
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Transferrin-facilitated lipofection gene delivery strategy: characterization of the transfection complexes and intracellular trafficking
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7 January 2021
based on heuristic
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Amphiphilic peptides enhance the efficiency of liposome-mediated DNA transfection
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7 January 2021
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Development of a novel fusogenic viral liposome system (HVJ-liposomes) and its applications to the treatment of acquired diseases
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Increased expression of DNA cointroduced with nuclear protein in adult rat liver
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Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes
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Nuclear localisation sequence templated nonviral gene delivery vectors: investigation of intracellular trafficking events of LMD and LD vector systems
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Thermodynamic aspects and biological profile of CDAN/DOPE and DC-Chol/DOPE lipoplexes
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Influence of membrane-active peptides on lipospermine/DNA complex mediated gene transfer.
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Gemini surfactants: new synthetic vectors for gene transfection
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Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method
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An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery
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Liposomes revisited
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The Structure of DNA−Liposome Complexes
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Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung
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7 January 2021
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Lyophilization of cationic lipid-protamine-DNA (LPD) complexes
1 reference
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7 January 2021
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In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
1 reference
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Crossref
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7 January 2021
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Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery
1 reference
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7 January 2021
based on heuristic
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Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection
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7 January 2021
based on heuristic
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Surface functionalized cationic lipid-DNA complexes for gene delivery: PEGylated lamellar complexes exhibit distinct DNA-DNA interaction regimes
1 reference
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7 January 2021
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Rational approaches to the design of cationic gemini surfactants for gene delivery
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7 January 2021
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Optimization of liposome mediated transfection of a neuronal cell line
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7 January 2021
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The problem with cationic liposome/micelle-based non-viral vector systems for gene therapy
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7 January 2021
based on heuristic
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Protamine-modified DDAB lipid vesicles promote gene transfer in the presence of serum.
1 reference
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7 January 2021
based on heuristic
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Targeted gene transfer to hepatocellular carcinoma cells in vitro using a novel monoclonal antibody-based gene delivery system.
1 reference
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7 January 2021
based on heuristic
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Pharmacokinetics of antisense oligodeoxyribonucleotides (cyclin B1 and CDC 2 kinase) in the vessel wall in vivo: enhanced therapeutic utility for restenosis by HVJ-liposome delivery
1 reference
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7 January 2021
based on heuristic
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Membrane perturbation and the mechanism of lipid-mediated transfer of DNA into cells
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7 January 2021
based on heuristic
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Gene delivery systems using the Sendai virus
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7 January 2021
based on heuristic
inferred from DOI database lookup
Gene transduction for disseminated intraperitoneal tumor using cationic liposomes containing non-histone chromatin proteins: cationic liposomal gene therapy of carcinomatosa
1 reference
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7 January 2021
based on heuristic
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Cationic lipids for transfection
1 reference
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7 January 2021
based on heuristic
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Anionic polyethyleneglycol lipids added to cationic lipoplexes increase their plasmatic circulation time
1 reference
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7 January 2021
based on heuristic
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Transfection properties of stabilized plasmid-lipid particles containing cationic PEG lipids
1 reference
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7 January 2021
based on heuristic
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Synthesis and formulation of neoglycolipids for the functionalization of liposomes and lipoplexes
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7 January 2021
based on heuristic
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Sterically stabilized BGTC-based lipoplexes: structural features and gene transfection into the mouse airways in vivo
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7 January 2021
based on heuristic
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Structural characteristics of supramolecular assemblies formed by guanidinium-cholesterol reagents for gene transfection
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7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison between the interactions of adenovirus-derived peptides with plasmid DNA and their role in gene delivery mediated by liposome-peptide-DNA virus-like nanoparticles
1 reference
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https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced folate receptor mediated gene therapy using a novel pH-sensitive lipid formulation
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization and transfection properties of lipoplexes stabilized with novel exchangeable polyethylene glycol-lipid conjugates.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): reciprocal effect of cationic lipid for in vitro and in vivo gene transfer
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Crossref
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https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Encapsulation of plasmid DNA in stabilized plasmid-lipid particles composed of different cationic lipid concentration for optimal transfection activity
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
DNA packing in stable lipid complexes designed for gene transfer imitates DNA compaction in bacteriophage
1 reference
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https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Gene transfer mediated by fusion protein hemagglutinin reconstituted in cationic lipid vesicles
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthetic DNA-compacting peptides derived from human sequence enhance cationic lipid-mediated gene transfer in vitro and in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 and PTEN/MMAC1/TEP1 gene therapy of human prostate PC-3 carcinoma xenograft, using transferrin-facilitated lipofection gene delivery strategy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Noninvasive gene targeting to the brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct synthesis of plasmenylcholine from allyl-substituted glycerols
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Novel Series of Amphiphilic Imidazolinium Compounds for in Vitro and in Vivo Gene Delivery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cationic liposome and plasmid DNA complexes formed in serum-free medium under optimum transfection condition are negatively charged
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protamine sulfate enhances lipid-mediated gene transfer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu and plasmid DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilized plasmid-lipid particles for systemic gene therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transferrin receptor-mediated gene transfer to the corneal endothelium
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antibody targeted gene transfer to endothelium.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic study of DNA condensation by cationic peptides used in nonviral gene therapy: analogy of DNA condensation to protein folding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preparation of plasmenylcholine lipids and plasmenyl-type liposome dispersions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transfection using synthetic peptides: comparison of three DNA-compacting peptides and effect of centrifugation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of a self-assembling nuclear targeting vector system based on the tetracycline repressor protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Binding and uptake of transferrin-bound liposomes targeted to transferrin receptors of endothelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Delivery to cancer cells of antisense L-myc oligonucleotides incorporated in fusogenic, cationic-lipid-reconstituted influenza-virus envelopes (cationic virosomes).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilized plasmid-lipid particles: construction and characterization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Self-assembly of a virus-mimicking nanostructure system for efficient tumor-targeted gene delivery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physicochemical characterization and purification of cationic lipoplexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of epidermal growth factor, transferrin, and insulin on lipofection efficiency in human lung carcinoma cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lectin enhancement of the lipofection efficiency in human lung carcinoma cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HVJ (Sendai virus)-cationic liposomes: a novel and potentially effective liposome-mediated technique for gene transfer to the airway epithelium
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of a DNA nuclear targeting sequence on gene transfer and expression of plasmids in the intact vasculature
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A sterically stabilized immunolipoplex for systemic administration of a therapeutic gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced transfection efficiency of a systemically delivered tumor-targeting immunolipoplex by inclusion of a pH-sensitive histidylated oligolysine peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Receptor-mediated delivery of an antisense gene to human brain cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antisense gene therapy of brain cancer with an artificial virus gene delivery system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Absence of toxicity of chronic weekly intravenous gene therapy with pegylated immunoliposomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilized plasmid-lipid particles for regional gene therapy: formulation and transfection properties
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2953004-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0065-2660(05)53004-9
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16240991
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16240991%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
PubMed publication ID
16240991
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16240991
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16240991%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 January 2020
16243061
reason for deprecated rank
unchecked identifier
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