(Q36300043)

13 August 2017

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title

Investigations on gossypol: past and present developments (English)

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13 August 2017

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Kalliopi Dodou

1

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13 August 2017

Rosaleen J Anderson

series ordinal

2

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13 August 2017

David A P Small

series ordinal

3

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13 August 2017

Paul W Groundwater

series ordinal

4

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13 August 2017

language of work or name

English

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publication date

1 November 2005

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Expert Opinion on Investigational Drugs

13 August 2017

published in

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13 August 2017

volume

14

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13 August 2017

issue

11

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13 August 2017

page(s)

1419-1434

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On the botanical distribution of chiral forms of gossypol

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Gossypol: a contraceptive for men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Structure-activity studies on gossypol in tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Gossypol treatment of recurrent adult malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Antimalarial activity of new gossypol derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Gossypol: prototype of inhibitors targeted to dinucleotide folds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Cytotoxicity of enantiomers of gossypol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Interaction of gossypol with sperm macromolecules and enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Gossypol-induced apoptotic DNA fragmentation correlates with inhibited protein kinase C activity in spermatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Potency, selectivity and cell cycle dependence of catechols in human tumour cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Novel pharmacophore-based methods reveal gossypol as a reverse transcriptase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Environmental inhibition of 11beta-hydroxysteroid dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Inhibitory effects of gossypol on corticosteroid 11-beta-hydroxysteroid dehydrogenase from guinea pig kidney: a possible mechanism for causing hypokalemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+)- and (-)-stereoisomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Aldose reductase inhibitors from the nature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Novel effects of gossypol, a chemical contraceptive in man: mobilization of internal Ca(2+) and activation of external Ca(2+) entry in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Gossypol inhibition of adenylate cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Antiproliferative activity of gossypol and gossypolone on human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Gossypol effects on cultured normal and malignant melanocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Gossypol: uncoupling of respiratory chain and oxidative phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

New thioderivatives of gossypol and gossypolone, as prodrugs of cytotoxic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

Antiproliferative effect of gossypol and its optical isomers on human reproductive cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.11.1419

10.1517/13543784.14.11.1419

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference