(Q36311897)

13 August 2017

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title

Cellular location of insulin-triggered signals and implications for glucose uptake (English)

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13 August 2017

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3

Amira Klip

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13 August 2017

Nish Patel

1

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PubMed ID

16284741

13 August 2017

Carol Huang

series ordinal

2

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13 August 2017

12 November 2005

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13 August 2017

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13 August 2017

451

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13 August 2017

4

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13 August 2017

499-510

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https://scigraph.springernature.com/pub.10.1007/s00424-005-1475-6

13 August 2017

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cites work

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

Characterisation of proteins associated with the GLUT4 intracellular compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

VAMP2, but not VAMP3/cellubrevin, mediates insulin-dependent incorporation of GLUT4 into the plasma membrane of L6 myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

IRS proteins and the common path to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-005-1475-6

Chemotaxis: signalling the way forward

21 January 2018

1 reference

12 December 2020

Insulin receptor substrate-2 is not necessary for insulin- and exercise-stimulated glucose transport in skeletal muscle

1 reference

12 December 2020

Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance.

1 reference

12 December 2020

The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation

1 reference

12 December 2020

Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways

1 reference

12 December 2020

Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: potential involvement of a membrane skeleton

1 reference

12 December 2020

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

1 reference

12 December 2020

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

12 December 2020

Expression of constitutively active Akt/protein kinase B signals GLUT4 translocation in the absence of an intact actin cytoskeleton

1 reference

12 December 2020

Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action

1 reference

12 December 2020

Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes

1 reference

12 December 2020

Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

1 reference

12 December 2020

Oxidant stress reduces insulin responsiveness in 3T3-L1 adipocytes.

1 reference

12 December 2020

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

1 reference

12 December 2020

Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway

1 reference

12 December 2020

Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport

1 reference

12 December 2020

Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues

1 reference

12 December 2020

Insulin regulation of membrane-associated insulin receptor substrate 1.

1 reference

12 December 2020

Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells

1 reference

12 December 2020

Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin

1 reference

12 December 2020

Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

1 reference

12 December 2020

Targeting of the Akt/PKB kinase to the actin skeleton.

1 reference

12 December 2020

Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes

1 reference

12 December 2020

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

12 December 2020

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

12 December 2020

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

1 reference

12 December 2020

Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes

1 reference

12 December 2020

GLUT4 retention in adipocytes requires two intracellular insulin-regulated transport steps

1 reference

12 December 2020

A family with severe insulin resistance and diabetes due to a mutation in AKT2.

1 reference

12 December 2020

Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes.

1 reference

12 December 2020

Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling

1 reference

12 December 2020

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

1 reference

12 December 2020

Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation

1 reference

12 December 2020

Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance

1 reference

12 December 2020

Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes

1 reference

12 December 2020

Akt activation is required at a late stage of insulin-induced GLUT4 translocation to the plasma membrane.

1 reference

12 December 2020

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

1 reference

12 December 2020

Functional consequence of targeting protein kinase B/Akt to GLUT4 vesicles

1 reference

12 December 2020

Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

1 reference

12 December 2020

Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c

1 reference

12 December 2020

Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin

1 reference

12 December 2020

In vivo adenoviral delivery of recombinant human protein kinase C-zeta stimulates glucose transport activity in rat skeletal muscle

1 reference

12 December 2020

Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state

1 reference

12 December 2020

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells

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12 December 2020

GLUT4 gene regulation and manipulation

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12 December 2020

Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles

1 reference

12 December 2020

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

1 reference

12 December 2020

Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes

1 reference

12 December 2020

Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles

1 reference

12 December 2020

Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes

1 reference

12 December 2020

Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein

1 reference

12 December 2020

Insulin accelerates inter-endosomal GLUT4 traffic via phosphatidylinositol 3-kinase and protein kinase B.

1 reference

12 December 2020

A myosin-derived peptide C109 binds to GLUT4-vesicles and inhibits the insulin-induced glucose transport stimulation and GLUT4 recruitment in rat adipocytes

1 reference

12 December 2020

Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites

1 reference

12 December 2020

Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells.

1 reference

12 December 2020

Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells

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12 December 2020

Hyperosmolarity reduces GLUT4 endocytosis and increases its exocytosis from a VAMP2-independent pool in l6 muscle cells

1 reference

12 December 2020

Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways

1 reference

12 December 2020

Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance

1 reference

12 December 2020

A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B.

1 reference

12 December 2020

Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes

1 reference

12 December 2020

Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes

1 reference

12 December 2020

Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells

1 reference

12 December 2020

Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells

1 reference

12 December 2020

Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes.

1 reference

12 December 2020

Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes

1 reference

12 December 2020

Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation

1 reference

12 December 2020

Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake

1 reference

12 December 2020

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

1 reference

12 December 2020

Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.

1 reference

12 December 2020

Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin to stimulate translocation of GLUT4 to the cell surface in rat adipose cells.

1 reference

12 December 2020

Perspective: The insulin signaling system--a common link in the pathogenesis of type 2 diabetes

1 reference

12 December 2020

Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells

1 reference

12 December 2020

Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

1 reference

12 December 2020

Phosphoinositide kinases

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12 December 2020

Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling

1 reference

12 December 2020

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

1 reference

12 December 2020

An adipocentric view of signaling and intracellular trafficking

1 reference

12 December 2020

Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting

1 reference

12 December 2020

The Effects of Wortmannin on Rat Skeletal Muscle

1 reference

12 December 2020

Caveolin-associated filamentous actin (Cav-actin) defines a novel F-actin structure in adipocytes

1 reference

12 December 2020

Separation of IRS-1 and PI3-kinase from GLUT4 vesicles in rat skeletal muscle

1 reference

12 December 2020

Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance

1 reference

12 December 2020

Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus

1 reference

12 December 2020

Activity, phosphorylation state and subcellular distribution of GLUT4-targeted Akt2 in rat adipose cells

1 reference

12 December 2020

Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes

1 reference

12 December 2020

Effects of transiently expressed atypical (zeta, lambda), conventional (alpha, beta) and novel (delta, epsilon) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific in

1 reference

12 December 2020

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle

1 reference

12 December 2020

Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase

1 reference

12 December 2020

Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane.

1 reference

12 December 2020

Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.

1 reference

12 December 2020

The vesicle- and target-SNARE proteins that mediate Glut4 vesicle fusion are localized in detergent-insoluble lipid rafts present on distinct intracellular membranes

1 reference

12 December 2020

Cellubrevin is a resident protein of insulin-sensitive GLUT4 glucose transporter vesicles in 3T3-L1 adipocytes

1 reference

12 December 2020

Insulin receptor substrate 3 is not essential for growth or glucose homeostasis.

1 reference

12 December 2020

Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM.

1 reference

12 December 2020

Protein kinase C-theta (PKCtheta): it's all about location, location, location.

1 reference

12 December 2020

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

1 reference

12 December 2020

Surfing the insulin signaling web

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12 December 2020

Cell migration: Rho GTPases lead the way

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12 December 2020

Regulated transport of the glucose transporter GLUT4

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12 December 2020

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

1 reference

12 December 2020

Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes

1 reference

12 December 2020

Insulin action and insulin resistance in human skeletal muscle

1 reference

12 December 2020

Insulin increases the association of Akt-2 with Glut4-containing vesicles

1 reference

12 December 2020

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1 reference

12 December 2020

Different subcellular distribution and regulation of expression of insulin receptor substrate (IRS)-3 from those of IRS-1 and IRS-2

1 reference

12 December 2020

Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta

1 reference

12 December 2020

Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes

1 reference

12 December 2020

Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis.

1 reference

12 December 2020

10.1007/S00424-005-1475-6

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16284741