(Q36312078)

13 August 2017

1 reference

title

The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions (English)

1 reference

13 August 2017

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Uetrecht JP

1

1 reference

13 August 2017

language of work or name

English

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publication date

1 January 1992

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13 August 2017

published in

Drug Metabolism Reviews

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13 August 2017

volume

24

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13 August 2017

issue

3

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13 August 2017

page(s)

299-366

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The immunologic and metabolic basis of drug hypersensitivities

13 August 2017

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Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals

21 January 2018

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Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis

21 January 2018

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21 January 2018

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The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: A stopped-flow kinetic study

21 January 2018

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Assessment of the propensity for covalent binding of electrophiles to biological substrates

21 January 2018

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Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.

21 January 2018

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Prostaglandin endoperoxide synthetase-mediated metabolism of carcinogenic aromatic amines and their binding to DNA and protein.

21 January 2018

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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

21 January 2018

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Tissue destruction by neutrophils

21 January 2018

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Mechanism of hypersensitivity reactions: proposed involvement of reactive metabolites generated by activated leukocytes

21 January 2018

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Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs

21 January 2018

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Metabolism of procainamide to a hydroxylamine by human neutrophils and mononuclear leukocytes

21 January 2018

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Generation of free radical intermediates from foreign compounds by neutrophil-derived oxidants

21 January 2018

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Autoxidative formation of a chemically reactive intermediate from amodiaquine, a myelotoxin and hepatotoxin in man.

21 January 2018

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Immunogenicity of amodiaquine in the rat

21 January 2018

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Thiols as myeloperoxidase-oxidase substrates

21 January 2018

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N-chlorination of phenytoin by myeloperoxidase to a reactive metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Metabolic activation of 1-naphthol and phenol by a simple superoxide-generating system and human leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Drug-Induced Agranulocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Drug-induced agranulocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Drug-induced agranulocytosis: review of possible mechanisms, and prospects for clozapine studies

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539208996297

The Use of in Vitro Technics to Study Drug-Induced Pancytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

THE EFFECT OF DRUGS IN THE PRODUCTION OF AGRANULOCYTOSIS WITH PARTICULAR REFERENCE TO AMIDOPYRINE HYPERSENSITIVITY

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539208996297

Severe neutropenia associated with sustained-release procainamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Severe neutropenia associated with procainamide: comparison of sustained release and conventional preparations.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539208996297

Another case of procainamide-induced pancytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Procainamide-induced thrombocytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Severe transient pancytopenia associated with procainamide ingestion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Procainamide-associated pancytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Reticulocytopenic, coombs' positive anemia induced by procainamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Procainamide-induced hemolytic anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Positive Direct Antiglobulin Tests and Immune Hemolytic Anemia in Patients Receiving Procainamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Pseudoleukemia during recovery from dapsone-induced agranulocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Dapsone and aplastic anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Trimethoprim-sulphamethoxazole-associated blood dyscrasias. Ten years' experience of the Swedish spontaneous reporting system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Drug-induced immunological neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Aminoglutethimide in the treatment of advanced breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Fatal aplastic anaemia following prolonged diclofenac use in an elderly patient

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Statewide Study of Chloramphenicol Therapy and Fatal Aplastic Anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Letter: Chloramphenicol eye-drops and marrow aplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Chloramphenicol: relation of structure to activity and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Bone marrow toxicity in vitro of chloramphenicol and its metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Formation and disposition of nitrosochloramphenicol in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Aerobic nitroreduction of dehydrochloramphenicol by bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

DNA damage in intact cells induced by bacterial metabolites of chloramphenicol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Agranulocytosis Induced by Certain Phenothiazine Derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Amodiaquine-induced agranulocytosis: report of a case with in vitro studies of granulocyte-macrophage progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Amodiaquine-induced immune agranulocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

The toxicity of amodiaquine and its principal metabolites towards mononuclear leucocytes and granulocyte/monocyte colony forming units

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Leucopenia in association with mianserin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Mianserin and agranulocytosis in New Zealand.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Mianserin and blood dyscrasias

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Thrombocytopenia and leucopenia with mianserin-dependent antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Agranulocytosis during treatment with chlozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Clozapine and agranulocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Adverse effects related to thionamide drugs and their dose regimen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Propylthiouracil-induced agranulocytosis: an unusual presentation and a possible mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Transient Methimazole-induced Bone Marrow Aplasia: in vitro Evidence for a Humoral Mechanism of Bone Marrow Suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Myelotoxicity of D-penicillamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Adverse effects of D-penicillamine in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Adverse effects profile of sulfhydryl compounds in man

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539208996297

Carbamazepine and hematological monitoring

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539208996297

Hematological effects of carbamazepine in patients with affective illness

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539208996297

Fatal aplastic anemia in a patient treated with carbamazepine

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539208996297

Study of fatal bone marrow depression with special reference to phenylbutazone and oxyphenbutazone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

The toxic effects of phenylbutazone (butazolidin); review of the literature and report of the twenty-third death following its use.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539208996297

An interaction of benzene metabolites reproduces the myelotoxicity observed with benzene exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Aromatic DNA adducts in human bone marrow and peripheral blood leukocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

The development of neutrophilic polymorphonuclear leukocytes in human bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Mechanism of drug-induced lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Drug-induced systemic lupus erythematosus: A critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Drug-induced antinuclear antibodies and lupus syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Antibodies to Histones in Drug-Induced and Idiopathic Lupus Erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Acetylator phenotype and lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Remission of Procainamide-Induced Lupus Erythematosus with N-Acetylprocainamide Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Systemic lupus erythematosus presenting with sulphonamide hypersensitivity reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Sulfonamide reactions in systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Development of antinuclear antibodies during acebutolol therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Systemic lupus erythematosus syndrome induced by practolol.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Isoniazid acetylatlon rate and development of antinuclear antibodies upon isoniazid treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Isoniazid induction of antinuclear antibodies. A prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Hydralazine-induced lupus: is there a toxic metabolic pathway?

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539208996297

Metabolic activation of hydralazine by rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Granulocytopenia, lupus-like syndrome, and other complications of propylthiouracil therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Lupus-like syndrome--a rare complication in thionamide treatment for Graves' disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Chlorpromazine-induced systemic lupus erythematosus: case report and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Immunologic and Coagulation Disorders in Chlorpromazine-Treated Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

The Role of Enzymatic Coupling of Drugs to Proteins in Induction of Drug Specific Antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Induction of antibodies to nuclear antigens in rabbits by immunization with hydralazine-human serum albumin conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Experimental studies on the mechanism of induction of anti-nuclear antibodies by procainamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

An anti-neutrophil antibody associated with a propylthiouracil-induced lupus-like syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Human peripheral blood monocytes display surface antigens recognized by monoclonal antinuclear antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Effects of hydrazyl group containing drugs on leucocyte functions: an immunoregulatory model for the hydralazine-induced lupus-like syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Immunomodulatory effect of procainamide in man. Inhibition of human suppressor T-cell activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

In vitro evaluation of a toxic metabolite of sulfadiazine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Complications of co-trimoxazole in treatment of AIDS-associated Pneumocystis carinii pneumonia in homosexual men

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Adverse Reactions to Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Adverse reactions to trimethoprim-sulfamethoxazole in hemophiliacs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Systemic glutathione deficiency in symptom-free HIV-seropositive individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Fatal Reaction to Dapsone During Treatment of Leprosy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Adverse reactions to procainamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

N-hydroxylation of 4,4'-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Apparent vasculitis associated with propylthiouracil use

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Cutaneous vasculitis associated with propylthiouracil therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Polyarthritis induced by propylthiouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Induction of auto-immune syndromes by penicillamine therapy in rheumatoid arthritis and other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

In vitro analysis of idiosyncratic drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Structural requirements for bioactivation of anticonvulsants to cytotoxic metabolites in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Disposition and irreversible plasma protein binding of tolmetin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Irreversible binding of tolmetin glucuronic acid esters to albumin in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Effect of stress on drug hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Antiarrhythmic efficacy, pharmacokinetics and safety of N-acetylprocainamide in human subjects: Comparison with procainamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Enzymatic activation of chemicals to toxic metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Recent advances in the metabolism and toxicity of benzene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Immunologic mechanism in sulphasalazine-induced agranulocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Antinuclear antibodies in chronic psychotic patients treated with chlorpromazine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

Aminoglutethimide-induced leukopenia: a case report and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

N-chlorination of dilantin and sorbinil

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

In VitroImmunoreactivity to Propylthiouracil, Methimazole, and Carbimazole in Patients with Graves’ Disease: A Possible Cause of Antithyroid Drug-Induced Agranulocytosis*

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996297

10.3109/03602539208996297

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference