(Q39847955)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3926381%20AND%20SRC:MED&resulttype=core&format=json

7 October 2019

review article

1 reference

title

Enzymatic activation of chemicals to toxic metabolites (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3926381%20AND%20SRC:MED&resulttype=core&format=json

7 October 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3926381%20AND%20SRC:MED&resulttype=core&format=json

7 October 2019

author name string

Guengerich FP

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3926381%20AND%20SRC:MED&resulttype=core&format=json

7 October 2019

language of work or name

English

0 references

publication date

1 January 1985

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3926381%20AND%20SRC:MED&resulttype=core&format=json

Critical Reviews in Toxicology

7 October 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3926381%20AND%20SRC:MED&resulttype=core&format=json

7 October 2019

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3926381%20AND%20SRC:MED&resulttype=core&format=json

7 October 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3926381%20AND%20SRC:MED&resulttype=core&format=json

7 October 2019

page(s)

259-307

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3926381%20AND%20SRC:MED&resulttype=core&format=json

Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules.

7 October 2019

cites work

1 reference

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Metabolic activation and drug toxicity

21 January 2018

1 reference

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Prostaglandin endoperoxide synthetase-mediated metabolism of carcinogenic aromatic amines and their binding to DNA and protein.

21 January 2018

1 reference

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Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Isolation and purification of cytochrome P-450, and the existence of multiple forms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Cytochrome P-450 as a determinant of sex difference of drug metabolism in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The rabbit pulmonary monooxygenase system: Characteristics and activities of two forms of pulmonary cytochrome P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Purification and characterization of microsomal cytochrome P-450s

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The turnover of cytochrome P450b.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Purification of mixed-function amine oxidase from rat liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Cocaine-induced hepatic necrosis in mice—The role of cocaine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Oxidation of trichloroethylene by liver microsomal cytochrome P-450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Olefin oxidation by cytochrome P-450: evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-butene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Oxidation of monosubstituted olefins by cytochromes P-450 and heme models: evidence for the formation of aldehydes in addition to epoxides and allylic alcohols

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Suicidal destruction of cytochrome P-450 during oxidative drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Destruction of cytochrome P-450 by vinyl fluoride, fluroxene, and acetylene. Evidence for a radical intermediate in olefin oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Toxicology of thiono-sulfur compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Studies on the activation of a model furan compound--toxicity and covalent binding of 2-(N-ethylcarbamoylhydroxymethyl)furan

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Biochemical mechanisms in chemical-induced lung injury: roles of metabolic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Studies on the in vitro transfer of DNA binding benzo[a]pyrene metabolites from rat hepatocytes to human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Nuclear Activation of Polycyclic Hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The mechanism of reductive dehalogenation of halothane by liver cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The role of glutathione in detoxication

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Glutathione-mediated binding of dibromoalkanes to DNA: specificity of rat glutathione-S-transferases and dibromoalkane structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Studies on glutathione S-alkyltransferase of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Nucleic acid adducts of chemical carcinogens and mutagens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Cytochrome P-450: a pharmacological necessity or a biochemical curiosity?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Degradation of proteins microinjected into IMR-90 human diploid fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Relationship between the genetically determined acetylator phenotype and DNA damage induced by hydralazine and 2-aminofluorene in cultured rabbit hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Polymorphisms of Oxidation at Carbon Centers of Drugs and Their Clinical Significance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Inherited defects of hepatic drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Mechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-diol 9,10-epoxide by riboflavin 5'-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Effects of nutritive factors on metabolic processes involving bioactivation and detoxication of chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Possible mechanism of liver necrosis caused by aromatic organic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The role of methionine in glutathione biosynthesis by isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Chemical Mechanisms of Halocarbon Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Mechanisms of hydroxylation by cytochrome P-450: metabolism of monohalobenzenes by phenobarbital-induced microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Mutagenic and carcinogenic N-nitroso compounds: possible environmental hazards

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Pyrrolic and N-oxide metabolites formed from pyrrolizidine alkaloids by hepatic microsomes in vitro: relevance to in vivo hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The microsomal metabolism of the organometallic derivatives of the group-IV elements, germanium, tin and lead

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Massive hepatic necrosis after fluroxene anesthesia--a case of drug interaction?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The role of cytochrome P-450 in the toxicity of fluroxene (2,2,2-trifluoroethyl vinyl ether) anaesthesia in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Destruction of highly purified cytochromes P-450 associated with metabolism of fluorinated ether anesthetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Acute toxicity of fluorinated ether anesthetics: Role of 2,2,2-trifluoroethanol and other metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Genotoxicity of pyrrolizidine alkaloids in the hepatocyte primary culture/DNA-repair test.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Evaluation in vitro of several pyrrolizidine alkaloid carcinogens: observations on the essential pyrrolic nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Tumor-Inhibitory Activity of Pyrrolizidine Alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Relation of structural features to pyrrolic metabolites in livers of rats given pyrrolizidine alkaloids and derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Reaction of dihydropyrrolizines with deoxyribonucleic acids in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Metabolic oxidation of acetaminophen (paracetamol) mediated by cytochrome P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

N-Hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Biochemical effects of 1,1-dichloroethylene in rats: comparison with carbon tetrachloride and 1,2-dichloroethylene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Effect of 18 HR fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

1,1-Dichloroethylene nephrotoxicity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The biological fate of vinylidene chloride in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Reactions of trichloroethylene epoxide in aqueous systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Molecular mechanism of 1,1-dichloroethylene toxicity: excreted metabolites reveal different pathways of reactive intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

Metabolism, cytotoxicity, and genotoxicity of the pyrrolizidine alkaloid senecionine in primary cultures of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509037460

The biosynthesis of retronecine

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1139/V82-095

Identifiers

DOI

10.3109/10408448509037460

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3926381%20AND%20SRC:MED&resulttype=core&format=json

7 October 2019

1 reference