(Q40323852)

19 September 2017

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title

Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation (English)

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19 September 2017

H Sies

2

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author name string

H Kappus

series ordinal

1

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19 September 2017

1 December 1981

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19 September 2017

9

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inferred from page(s)

published in

Experientia

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19 September 2017

37

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19 September 2017

1233-1241

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19 September 2017

12

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Hydroxyl radical production by free and DNA-bound aminoquinone antibiotics and its role in DNA degradation. Electron spin resonance detection of hydroxyl radicals by spin trapping

19 September 2017

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12 December 2020

Influence of oxygen on the inhibition of liver microsomal activation of carbon tetrachloride by the catechol 2-hydroxyestradiol-17 beta

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12 December 2020

Metabolism of carbon tetrachloride in hepatic microsomes and reconstituted monooxygenase systems and its relationship to lipid peroxidation

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12 December 2020

Oxygen dependence of CCl4-induced lipid peroxidation in vitro and in vivo

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12 December 2020

Role of superoxide dismutase in cancer: a review

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12 December 2020

Microsomal NADPH-dependent lipid peroxidation does not require the presence of intact cytochrome P450.

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12 December 2020

Paraquat-induced alterations of phospholipids and GSSG-release in the isolated perfused rat liver, and the effect of SOD-active copper complexes

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12 December 2020

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

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12 December 2020

Ethane formation of isolated rat hepatocytes due to carbon tetrachloride

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12 December 2020

Superoxide production by purified hamster hepatic nuclei

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12 December 2020

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation

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12 December 2020

Regulatory role of glutathione and soluble sulfhydryl groups in the toxicity of adriamycin

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12 December 2020

Critical role of lipid peroxidation in carbon tetrachloride-induced loss of aminopyrine demethylase, cytochrome P-450 and glucose 6-phosphatase

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12 December 2020

Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism

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12 December 2020

Binding of 14 C-carbon tetrachloride to microsomal proteins in vitro and formation of CHC1 3 by reduced liver microsomes

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12 December 2020

Acute adriamycin treatment of rats does not increase ethane expiration

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12 December 2020

A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo

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12 December 2020

Toxicity of nitro compounds toward hypoxic mammalian cells in vitro: dependence on reduction potential

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12 December 2020

Mechanism of the microsomal reduction of carbon tetrachloride and halothane.

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12 December 2020

Self-catalysed, O2-independent inactivation of NADPH- or dithionite-reduced microsomal cytochrome P-450 by carbon tetrachloride

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12 December 2020

The production of hydroxyl radical by bleomycin and iron (ii)

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12 December 2020

Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation

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12 December 2020

Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin

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12 December 2020

Evidence for superoxide generation by NADPH-cytochrome c reductase of rat liver microsomes

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12 December 2020

Chemicals, drugs, and lipid peroxidation

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12 December 2020

Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds

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12 December 2020

New developments on the mechanisms of action of antineoplastic drugs

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12 December 2020

Studies on the irreversible binding of 14 C-CCl 4 to microsomal lipids in rats under varying experimental conditions

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12 December 2020

Oxidation of arachidonic acid in micelles by superoxide and hydrogen peroxide.

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12 December 2020

Confirmation of assignment of the trichloromethyl radical spin adduct detected by spin trapping during 13C-carbon tetrachloride metabolism , , , ,

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12 December 2020

Functions of intracellular glutathione in hepatic hydroperoxide and drug metabolism and the role of extracellular glutathione

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12 December 2020

Ultraweak chemiluminescence: a sensitive assay for oxidative radical reactions

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12 December 2020

The effect of paraquat on microsomal lipid peroxidation in vitro and in vivo

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12 December 2020

Role of superoxide in deoxyribonucleic acid strand scission

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12 December 2020

The reduction of polyhalogenated methanes by liver microsomal cytochrome P450

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12 December 2020

Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins

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12 December 2020

Effect of oxygen concentration on the reaction of halothane with cytochrome P450 in liver microsomes and isolated perfused rat liver

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12 December 2020

Lysis of erythrocytes as a result of microsomal lipid peroxidation induced by CCl4 or FeCl2

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12 December 2020

Conversion of benzo[a]pyrene-3,6-quinone to quinol glucuronides with rat liver microsomes or purified NADPH-cytochrome c reductase and UDP-glucuronosyltransferase

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12 December 2020

Alloxan-induced diabetes-evidence for hydroxyl radical as a cytotoxic intermediate

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12 December 2020

Comparative flavoprotein catalysis of anthracycline antibiotic. Reductive cleavage and oxygen consumption

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12 December 2020

Enhancement of bleomycin-iron free radical damage to DNA by antioxidants and their inhibition of lipid peroxidation

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12 December 2020

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity

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12 December 2020

Influence of hypoxia on the hepatotoxic effects of carbon tetrachloride, paracetamol, allyl alcohol, bromobenzene and thioacetamide

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12 December 2020

Active oxygen in liver microsomes: mechanism of epinephrine oxidation

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12 December 2020

Mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated fatty acids

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12 December 2020

Nutritional influence on cellular antioxidant defense systems

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12 December 2020

Hepatic Necrosis Caused by Halothane and Hypoxia in Phenobarbital-treated Rats

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12 December 2020

Effect of hypoxia on the cytotoxicity of misonidazole in HELA S3 cells in vitro

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12 December 2020

Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity

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12 December 2020

Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilete: Oxygenation or electron transfer?

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12 December 2020

A rationale for the design of cell-specific toxic agents: the mechanism of action of 6-hydroxydopamine

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12 December 2020

Spin trapping of free radical products of CC14 activation using pulse radiolysis and high energy radiation procedures

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12 December 2020

Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro.

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12 December 2020

Liver necrosis and lipid peroxidation in the rat as the result of paraquat and diquat administration. Effect of selenium deficiency

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12 December 2020

Lack of in vivo lipid peroxidation in experimental paraquat poisoning

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12 December 2020

Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: Role of cytochrome P-450

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12 December 2020

The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase

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12 December 2020

DNA strand scission by enzymically generated oxygen radicals

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12 December 2020

Irreversible binding of dopa and dopamine metabolites to protein by rat liver microsomes

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12 December 2020

Hepatic microsomal lipoperoxidation and inhalation anesthetics: a biochemical and morphologic study in the rat.

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12 December 2020

Determination of malondialdehyde-DNA crosslinks by fluorescence and incorporation of tritium

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12 December 2020

Spontaneous cancer and its possible relationship to oxygen metabolism

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12 December 2020

Inhibition of lipid peroxidation without prevention of cellular injury in isolated rat hepatocytes

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12 December 2020

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells

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12 December 2020

Degradation of deoxyribonucleic acid by a 1,10-phenanthroline-copper complex: the role of hydroxyl radicals

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12 December 2020

Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells.

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12 December 2020

Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi

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12 December 2020

Redox cycle of stable mixed nitroxides formed from carcinogenic aromatic amines

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12 December 2020

Selective toxicity of 5-S-cysteinyldopa, a melanin precursor, to tumor cells in vitro and in vivo

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12 December 2020

Covalent binding of carbon tetrachloride metabolites to liver nuclear DNA, proteins, and lipids

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12 December 2020

The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.

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12 December 2020

The hypoxic tumor cell: a target for selective cancer chemotherapy

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12 December 2020

In-vivo inhibition by copper and some Cu-complexes of paracetamol-induced lipid peroxidation in benzpyrene-pretreated mice

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12 December 2020

Vitamin E and selenium protection from in vivo lipid peroxidation

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12 December 2020

Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo

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12 December 2020

Interaction of epinephrine metabolites with the liver microsomal electron transport system

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12 December 2020

Formation of superoxide and hydroxy radicals in iron(II)-bleomycin-oxygen system: Electron spin resonance detection by spin trapping

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12 December 2020

Irreversible binding of 5-hydroxytryptamine and 5-hydroxytryptophan metabolites to rat liver microsomal protein

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12 December 2020

Metabolism of benzo[a]pyrene-3,6-quinone by isolated hepatocytes

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12 December 2020

O2-independent damage of cytochrome P450 by CCl4-metabolites in hepatic microsomes

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12 December 2020

Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo

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12 December 2020

Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.

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12 December 2020

Antioxidants and cancer. IV. Initiating activity of malonaldehyde as a carcinogen

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12 December 2020

Isobutene formation during halothane anaesthesia in man.

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12 December 2020

β-lapachone enhancement of lipid peroxidation and superoxide anion and hydrogen peroxide formation by Sarcoma 180 ascites tumor cells

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12 December 2020

Daunorubicin reduction mediated by aldehyde and ketone reductases

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12 December 2020

Mechanism of bleomycin action: studies

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12 December 2020

Ethane production by isolated perfused rat liver: a system to study metabolic effects related to lipid peroxidation

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12 December 2020

The mechanism of chloroform and carbon monoxide formation from carbon tetrachloride by microsomal cytochrome P-450

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12 December 2020

Long-Range Effects of Products of Carbon Tetrachloride-Stimulated Lipid Peroxidation

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12 December 2020

Stoichiometry of the mixed function oxidase

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12 December 2020

Role of biotransformation in the toxicity of inhalation anesthetics

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12 December 2020

Autoxidation of polyunsaturated fatty acids: II. A suggested mechanism for the formation of TBA‐reactive materials from prostaglandin‐like endoperoxides

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12 December 2020

Differential cytotoxicity of daunomycin in tumour cells is related to glutathione-dependent hydrogen peroxide metabolism

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12 December 2020

Comparison of the mutagenicities of malondialdehyde and the side products formed during its chemical synthesis.

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12 December 2020

Benzo[a]pyrenedione/benzo[a]pyrenediol oxidation-reduction couples and the generation of reactive reduced molecular oxygen

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12 December 2020

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

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12 December 2020

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents

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12 December 2020

Hydroperoxide metabolism in mammalian organs

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12 December 2020

Low-level chemiluminescence of isolated hepatocytes

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12 December 2020

Bleomycin toxicity: alterations in oxidative metabolism in lung and liver microsomal fractions

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12 December 2020

Identifiers

DOI

10.1007/BF01948335

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19 September 2017

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PubMed ID

7035210