(Q40147765)

17 September 2017

title

Chemical mechanisms of halocarbon metabolism (English)

1 reference

17 September 2017

Chemical Mechanisms of Halocarbon Metabolism (English)

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

author name string

T. L. Macdonald

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6340969

2 October 2023

publication date

1 January 1983

1 reference

full work available at URL

17 September 2017

language of work or name

English

0 references

http://www.tandfonline.com/doi/pdf/10.3109/10408448309089849

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Critical Reviews in Toxicology

2 October 2023

published in

1 reference

17 September 2017

volume

11

1 reference

17 September 2017

issue

2

1 reference

17 September 2017

page(s)

85-120

1 reference

publication type of scholarly work

17 September 2017

review article

1 reference

Cytochrome P-450 and its role in drug metabolism

cites work

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Metabolically Oxygenated Compounds: Formation, Conjugation, and Possible Biological Implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Novel Drug Metabolites Produced by Functionalization Reactions: Chemistry and Toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Novel Pathways in Drug Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

21 January 2018

Chemical carcinogenesis

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Carcinogenicity studies on halogenated hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Isolation and purification of cytochrome P-450, and the existence of multiple forms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Oxygen activation by cytochrome P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Mechanism of the microsomal reduction of carbon tetrachloride and halothane

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Competition between benzo[a]pyrene and various steroids for cytochrome P-450-dependent rat liver monooxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Investigation of the mechanism of the metabolic activation of chloramphenicol by rat liver microsomes. Identification of a new metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

The concept of regioselectivity in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

An ab initio study of electronic factors in metabolic hydroxylation of aliphatic carbon atoms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Metabolism of dihalomethanes to carbon monoxide--III. Studies on the mechanism of the reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Metabolism of haloforms to carbon monoxide--III. Studies on the mechanism of the reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Metabolism of dihalomethanes to formaldehyde and inorganic halide--II. Studies on the mechanism of the reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Mutagenic activation of dibromomethane and diiodomethane by mammalian microsomes and glutathione S-transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Deuterium isotope effect in bioactivation and hepatotoxicity of chloroform

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Deuterium isotope effect in in vivo bioactivation of chloroform to phosgene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Liver parenchymal cell injury. 8. Lesions of membranous cellular components following iodoform

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Bioactivation and covalent binding of halothane to liver macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Absorption, biotransformation, and storage of halothane

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Biotransformation and hepatotoxicity of halothane

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

The Oxidative Metabolism of 1-Bromopropane in the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Abnormal Sulphatase Activities in Two Human Diseases (Metachromatic Leucodystrophy and Gargoylism)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Chloroethanes: their metabolism by hepatic cytochrome P-450 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: Role of cytochrome P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

The effect of diet and 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) on microsomal hydroxylating enzymes and on sensitivity of rats to carbon tetrachloride poisoning

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Carbon tetrachloride hepatotoxicity: an example of lethal cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

The dangers from limited exposure to carbon tetrachloride

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Carbon tetrachloride metabolism in the rabbit

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

The stimulatory effects of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. General features of the systems used

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

The mechanism of halothane binding to microsomal cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Mixed-function oxidase involvement in the biochemistry of insecticide synergists

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Iodosylbenzene derivatives as oxygen donors in cytochrome P-450 catalyzed steroid hydroxylations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Angiosarcoma of the liver in a vinyl-chloride worker

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Rat liver microsomes catalyse covalent binding of 14C-vinyl chloride to macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Alkylation of DNA and proteins in mice exposed to vinyl chloride

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Metabolism of [14C]- and [36Cl]-labeled vinyl chloride in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Mutagenicity of vinyl chloride, chloroethyleneoxide, chloroacetaldehyde and chloroethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

The interaction of vinyl chloride with rat hepatic microsomal cytochrome P-450 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

On the possible mechanism of carcinogenic action of vinyl chloride

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Chemical reactivity, biotransformation, and toxicity of polychlorinated aliphatic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Irreversible binding of 14C-labelled trichloroethylene to mice liver constituents in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Pharmacology and toxicology of trichloroethylene. A critical review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Oxidation of trichloroethylene by liver microsomal cytochrome P-450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Chemical structure, reactivity, and carcinogenicity of halohydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Reactions of trichloroethylene epoxide in aqueous systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Carcinogenicity of trichloroethylene: fact or artifact?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Destruction of cytochrome P-450 by 2-isopropyl-4-pentenamide and methyl 2-isopropyl-4-pentenoate: Mass spectrometric characterization of prosthetic heme adducts and nonparticipation of epoxide metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Arene oxides: a new aspect of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Arene oxides as intermediates in the oxidative metabolism of aromatic compounds. Isomerization of methyl-substituted arene oxides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Novel rearrangements during dehydration of nucleophile adducts of arene oxides. Reappraisal of premercapturic acid structures

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Toxicology of chlorinated dibenzo-p-dioxins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Possible mechanism of liver necrosis caused by aromatic organic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Mechanism of renal necrosis induced by bromobenzene or chlorobenzene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Metabolism and binding of aromatic hydrocarbons in the lung. Relationship to experimental bronchiolar necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

3-methylcholanthrene blocks hepatic necrosis induced by administration of bromobenzene or carbon tetrachloride

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

The mechanism of reductive dehalogenation of halothane by liver cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

Consideration of the evidence for mechanisms of 1,1,2-trichloroethylene metabolism, including new identification of its dichloroacetic acid and trichloroacetic acid metabolites in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448309089849

A triple-threat in detoxification: the glutathione S-transferases

21 January 2018

2

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents

2 October 2023

3

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

American Journal of Physiology

2 October 2023

4

239

G439

Kaplowitz N

1980

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Drug Metabolism and Disposition

2 October 2023

7

1

299

Uehleke H

1973

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Cytochrome P450 and biological hydroxylation reactions

2 October 2023

22

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

Pharmacological Reviews

27

31

277

Lu A. Y. H.

1980

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

The mechanism of chloroform and carbon monoxide formation from carbon tetrachloride by microsomal cytochrome P-450

2 October 2023

30

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

31

13

698

Wolf C. R.

1977

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Journal of Biological Chemistry

2 October 2023

33

89

237

Thomas P. E.

1981

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

The Journal of Biochemistry

2 October 2023

34

256

1044

Harada N.

1981

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Tetrachloroethylene metabolism by the hepatic microsomal cytochrome P-450 system

2 October 2023

38

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Topics in Current Chemistry

2 October 2023

45

34

1

Fry A

1973

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Journal of the American Chemical Society

2 October 2023

46

95

8651

Koch V. R.

1973

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Regioelectronic factors in metabolic hydroxylation of aliphatic carbon atoms

2 October 2023

53

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Enzymatic dechlorination. Dechlorination of chloroethanes and propanes in vitro

2 October 2023

57

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

58

9

153

Loew G.

1973

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Metabolism of dihalomethanes to carbon monoxide. IV. Studies in isolated rat hepatocytes

2 October 2023

64

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

65

19

0000

Tachizawa H.

1982

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Phosgene: A metabolite of chloroform

2 October 2023

71

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Mechanism of metabolic activation of chloroform by rat liver microsomes

2 October 2023

75

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Chloroform-induced glutathione depletion and toxicity in freshly isolated hepatocytes

2 October 2023

76

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Reactivity and toxicity among halogenated methanes and related compounds. A physicochemical correlate with predictive value

2 October 2023

78

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

80

17

427

Halpert J.

1981

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Covalent modification of lysine during the suicide inactivation of rat liver cytochrome P-450 by chloramphenicol

2 October 2023

81

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Hepatotoxicity and Halothane Metabolism in an Animal Model with Application for Human Toxicity

2 October 2023

86

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Hepatic Necrosis Caused by Halothane and Hypoxia in Phenobarbital-treated Rats

2 October 2023

87

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Volatile metabolites and decomposition products of halothane in man.

2 October 2023

88

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Journal of Pharmacology and Experimental Therapeutics

2 October 2023

89

214

721

Gandolfi A. J.

1980

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Journal of Pharmacology and Experimental Therapeutics

2 October 2023

90

214

716

Sipes I. G.

1980

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450

2 October 2023

94

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

2 October 2023

95

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Radical mechanism of aminopyrine oxidation by cumene hydroperoxide catalyzed by purified liver microsomal cytochrome P-450

2 October 2023

97

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Mechanisms of hydroxylation by cytochrome P-450: exchange of iron-oxygen intermediates with water

2 October 2023

103

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

107

93

16P

James S. P.

1964

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Biosynthesis of Sulphated Hydroxypentylmercapturic Acids and the Metabolism of I-Bromopentane in the Rat

2 October 2023

109

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

The sub-cellullar partition and metabolism of oprally administered 1,1,1-Trichloro-2, 2-bis (p-chlorophenyl) ethane by rat liver cells

2 October 2023

112

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Binding of 14 C-carbon tetrachloride to microsomal proteins in vitro and formation of CHC1 3 by reduced liver microsomes

2 October 2023

113

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

115

18

553

Wolf C. R.

1980

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Increased susceptibility to carbon tetrachloride poisoning in the rat after pretreatment with oral phenobarbitone

2 October 2023

119

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

125

39

3942

Shah J.

1979

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Metabolism of carbon tetrachloride to phosgene

2 October 2023

126

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Detection of early metabolites in rat liver after administration of CCI4 and CBrCI3

2 October 2023

130

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

154

13

993

Guengerich F. P.

1977

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride

2 October 2023

156

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

158

40

352

Zajdela F.

1980

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

159

41

4391

Guengerich F. P.

1981

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

161

247

Byington K. H.

1965

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

163

36

2419

Van Duuren B. L.

1976

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

166

38

776

Banerjee S.

1978

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Environmental Health Perspectives

2 October 2023

174

21

61

Henschler D

1977

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Synthesis of 3- and 4-chlorobenzene oxides. Unexpected trapping results during metabolism of carbon-14-labeled chlorobenzene by hepatic microsomes

2 October 2023

183

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Metobolism of chlorobenzene with hepatic microsomes and solubilized cytochrome P-450 systems

2 October 2023

184

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Deuterium isotope effects during formation of phenols by hepatic monoxygenases. Evidence for an alternative to the arene oxide pathway

2 October 2023

185

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Metabolism of dichlorobiphenyls by hepatic microsomal cytochrome P-450

2 October 2023

187

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Bromobenzene Metabolism and Hepatic Necrosis

2 October 2023

189

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Journal of Pharmacology and Experimental Therapeutics

2 October 2023

193

187

218

Zampaglione N.

1973

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Induction, activation and inhibition of epoxide hydrase: an anomalous prevention of chlorobenzene-induced hepatotoxicity by an inhibitor of epoxide hydrase

2 October 2023

194

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Biliary excretion of metabolities of bromobenzene

2 October 2023

195

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity

2 October 2023

197

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

198

21

235

Lau S. S.

1979

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Hepatic microsomal epoxidation of bromobenzene to phenols and its toxicological implication

2 October 2023

199

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Journal of Pharmacology and Experimental Therapeutics

2 October 2023

200

214

703

Lau S. S.

1981

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

The reductive metabolism of halogenated alkanes by liver microsomal cytochrome P450

2 October 2023

203

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Specificity of a phenobarbital-induced cytochrome P-450 for metabolism of carbon tetrachloride to the trichloromethyl radical

2 October 2023

204

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

Oxidation of carbon tetrachloride, bromotrichloromethane, and carbon tetrabromide by rat liver microsomes to electrophilic halogens

2 October 2023

206

1 reference

https://api.crossref.org/works/10.3109/10408448309089849

2 October 2023

Identifiers

0 references

1 reference