(Q36313362)

13 August 2017

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title

Current challenges in quantitative modeling of epidermal growth factor signaling (English)

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13 August 2017

Rainer Breitling

1

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author name string

Daniela Hoeller

series ordinal

2

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PubMed ID

16288752

13 August 2017

language of work or name

English

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publication date

2 November 2005

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13 August 2017

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13 August 2017

579

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13 August 2017

28

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13 August 2017

6289-6294

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Computational modeling of the EGF-receptor system: a paradigm for systems biology

13 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

A spectrum of models of signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Multiple positive and negative regulators of signaling by the EGF-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Untangling the ErbB signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Signaling by the Drosophila epidermal growth factor receptor pathway during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

The epidermal growth factor system in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Clathrin-independent endocytosis of ubiquitinated cargos

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Time accelerated Monte Carlo simulations of biological networks using the binomial tau-leap method.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Sensitivity, principal component and flux analysis applied to signal transduction: the case of epidermal growth factor mediated signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Reduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Shc-dependent pathway is redundant but dominant in MAPK cascade activation by EGF receptors: a modeling inference

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

MAPK cascade possesses decoupled controllability of signal amplification and duration

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Control of EGF receptor signaling by clathrin-mediated endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin (K44A).

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Not just a sink: endosomes in control of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Analysis of receptor internalization as a mechanism for modulating signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

An integrated model of epidermal growth factor receptor trafficking and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Binomial distribution based tau-leap accelerated stochastic simulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Signaling through scaffold, anchoring, and adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Cytoplasmic PML function in TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

The complexity of complexes in signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

21 January 2018

All signaling is local?

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Activation of endogenous Cdc42 visualized in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Single-molecule imaging analysis of Ras activation in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Single-molecule imaging of EGFR signalling on the surface of living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Lateral propagation of EGF signaling after local stimulation is dependent on receptor density.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Local signaling by the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Mechanotransduction through growth-factor shedding into the extracellular space

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Signal processing at the Ras circuit: what shapes Ras activation patterns?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

EGF signalling amplification induced by dynamic clustering of EGFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Self-organization of polarized cell signaling via autocrine circuits: computational model analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Cbl signaling networks in the regulation of cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

EGFR signal transactivation in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

SmartCell, a framework to simulate cellular processes that combines stochastic approximation with diffusion and localisation: analysis of simple networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

The Virtual Cell: a software environment for computational cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2005.10.034

10.1016/J.FEBSLET.2005.10.034

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16288752