(Q36314384)

13 August 2017

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title

Dynamic conformational heterogeneities of carcinogen-DNA adducts and their mutagenic relevance (English)

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13 August 2017

Bongsup P Cho

1

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13 August 2017

1 January 2004

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Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews

13 August 2017

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13 August 2017

22

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13 August 2017

57-90

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13 August 2017

2

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13 August 2017

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Mechanisms of chemical carcinogenesis and application to human cancer risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

The uses of carcinogen-DNA adduct measurement in establishing mechanisms of mutagenesis and in chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

DNA adducts of chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

DNA adduct formation by polycyclic aromatic hydrocarbon dihydrodiol epoxides

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Evidence for the mutagenic potential of the vinyl chloride induced adduct, N2, 3-etheno-deoxyguanosine, using a site-directed kinetic assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Mutagenesis by (+)-anti-B[a]P-N2-Gua, the major adduct of activated benzo[a]pyrene, when studied in an Escherichia coli plasmid using site-directed methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

The major, N2-dG adduct of (+)-anti-B[a]PDE induces G-->A mutations in a 5'-AGA-3' sequence context.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Influence of flanking sequence context on the mutagenicity of acetylaminofluorene-derived DNA adducts in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

NMR solution structures of stereoisometric covalent polycyclic aromatic carcinogen-DNA adduct: principles, patterns, and diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Effect of aminofluorene and (acetylamino)fluorene adducts on the DNA replication mediated by Escherichia coli polymerases I (Klenow fragment) and III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Carcinogen-induced mutation spectrum in wild-type, uvrA and umuC strains of Escherichia coli. Strain specificity and mutation-prone sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Single adduct mutagenesis: strong effect of the position of a single acetylaminofluorene adduct within a mutation hot spot

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Carcinogen-induced frameshift mutagenesis in repetitive sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Translesional synthesis past acetylaminofluorene-derived DNA adducts catalyzed by human DNA polymerase kappa and Escherichia coli DNA polymerase IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

The 'A rule' of mutagen specificity: a consequence of DNA polymerase bypass of non-instructional lesions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

NMR structural studies of a 15-mer DNA duplex from a ras protooncogene modified with the carcinogen 2-aminofluorene: conformational heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Solution structure of the aminofluorene [AF]-intercalated conformer of the syn-[AF]-C8-dG adduct opposite dC in a DNA duplex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

A single site-specific trans-opened 7,8,9,10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct induces mutations at multiple sites in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

NMR evidence of the stabilisation by the carcinogen N-2-acetylaminofluorene of a frameshift mutagenesis intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

NMR data show that the carcinogen N-2-acetylaminofluorene stabilises an intermediate of -2 frameshift mutagenesis in a region of high mutation frequency

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Benzo[a]pyrene diol epoxide forms covalent adducts with deoxycytidylic acid by alkylation at both exocyclic amino N(4) and ring imino N-3 positions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Role of base sequence context in conformational equilibria and nucleotide excision repair of benzo[a]pyrene diol epoxide-adenine adducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Base sequence effects in bending induced by bulky carcinogen-DNA adducts: experimental and computational analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Bending and circularization of site-specific and stereoisomeric carcinogen-DNA adducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Multiple conformations of an intercalated (-)-(7S,8R,9S, 10R)-N6-[10-(7,8,9,10-tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

NMR evidence for syn-anti interconversion of a trans opened (10R)-dA adduct of benzo[a]pyrene (7S,8R)-diol (9R,10S)-epoxide in a DNA duplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Solution structure of the minor conformer of a DNA duplex containing a dG mismatch opposite a benzo[a]pyrene diol epoxide/dA adduct: glycosidic rotation from syn to anti at the modified deoxyadenosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Nuclear magnetic resonance solution structure of an undecanucleotide duplex with a complementary thymidine base opposite a 10R adduct derived from trans addition of a deoxyadenosine N6-amino group to (-)-(7R,8S,9R,10S)-7,8-dihydroxy- 9,10-epoxy-7,8,

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Solution structure of the (+)-cis-anti-benzo[a]pyrene-dA ([BP]dA) adduct opposite dT in a DNA duplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Solution structure of a cis-opened (10R)-N6-deoxyadenosine adduct of (9S,10R)-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a DNA duplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Solution structure of a trans-opened (10S)-dA adduct of (+)-(7S,8R,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully complementary DNA duplex: evidence for a major syn conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Minor groove orientation for the (1S,2R,3S,4R)-N2- [1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyguanosyl adduct in the N-ras codon 12 sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Intercalation of the (1R,2S,3R,4S)-N6-[1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence: DNA sequence effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Intercalation of the (-)-(1R,2S,3R, 4S)-N6-[1-benz[a]anthracenyl]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Solution conformation of the N-(deoxyguanosin-8-yl)-1-aminopyrene ([AP]dG) adduct opposite dC in a DNA duplex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Solution structure of the N-(deoxyguanosin-8-yl)-1-aminopyrene ([AP]dG) adduct opposite dA in a DNA duplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Effect of ring size on conformations of aromatic amine-DNA adducts: the aniline-C8 guanine adduct resides in the B-DNA major groove.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Mutations induced by aromatic amine DNA adducts in pBR322.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Solution conformation of the (+)-trans-anti-benzo[g]chrysene-dA adduct opposite dT in a DNA duplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Conformational determinants of structures in stereoisomeric cis-opened anti-benzo[a]pyrene diol epoxide adducts to adenine in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Evading the proofreading machinery of a replicative DNA polymerase: induction of a mutation by an environmental carcinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Frameshift mutation, microsatellites and mismatch repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Nucleic acid sequence and repair: role of adduct, neighbor bases and enzyme specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

What structural features determine repair enzyme specificity and mechanism in chemically modified DNA?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Acetylaminofluorene bound to different guanines of the sequence -GGCGCC- is excised with different efficiencies by the UvrABC excision nuclease in a pattern not correlated to the potency of mutation induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Human and E.coli excinucleases are affected differently by the sequence context of acetylaminofluorene-guanine adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Recognition and incision of site-specifically modified C8 guanine adducts formed by 2-aminofluorene, N-acetyl-2-aminofluorene and 1-nitropyrene by UvrABC nuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Differential incision of bulky carcinogen-DNA adducts by the UvrABC nuclease: comparison of incision rates and the interactions of Uvr subunits with lesions of different structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Base pair conformation-dependent excision of benzo[a]pyrene diol epoxide-guanine adducts by human nucleotide excision repair enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Hierarchy of DNA damage recognition in Escherichia coli nucleotide excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Relating repair susceptibility of carcinogen-damaged DNA with structural distortion and thermodynamic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Stereochemical, structural, and thermodynamic origins of stability differences between stereoisomeric benzo[a]pyrene diol epoxide deoxyadenosine adducts in a DNA mutational hot spot sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

How DNA lesions are turned into mutations within cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Uncoupling of leading- and lagging-strand DNA replication during lesion bypass in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Polymerases and the replisome: machines within machines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Effects of benzo[a]pyrene DNA adducts on Escherichia coli DNA polymerase I (Klenow fragment) primer-template interactions: evidence for inhibition of the catalytically active ternary complex formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Effects of benzo[a]pyrene adduct stereochemistry on downstream DNA replication in vitro: evidence for different adduct conformations within the active site of DNA polymerase I (Klenow fragment).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Significance of nucleobase shape complementarity and hydrogen bonding in the formation and stability of the closed polymerase-DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Induced circular dichroism of benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides used to probe equilibrium distribution between groove binding and intercalative adduct conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Studies on the adduct heterogeneity of benzo[a]pyrene 7, 8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and light absorption spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Fluorescence characteristics of site-specific and stereochemically distinct benzo[a]pyrene diol epoxide-DNA adducts as probes of adduct conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Fluorine-19 nuclear magnetic resonance studies of the structure of 5-fluorouracil-substituted Escherichia coli transfer RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

Hot spots of frameshift mutations induced by the ultimate carcinogen N- acetoxy-N-2-acetylaminofluorene

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FLESC-200038217

21 January 2018

Identifiers

DOI

10.1081/LESC-200038217

1 reference

13 August 2017

1 reference

PubMed ID

16291518