(Q36314443)

13 August 2017

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title

Clinical trials in amyotrophic lateral sclerosis: the tenuous past and the promising future (English)

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amyotrophic lateral sclerosis

13 August 2017

main subject

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2

Merit E Cudkowicz

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13 August 2017

Rabia B Choudry

1

1 reference

13 August 2017

publication date

1 December 2005

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The Journal of Clinical Pharmacology

13 August 2017

published in

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13 August 2017

volume

45

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13 August 2017

issue

12

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13 August 2017

page(s)

1334-1344

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From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Overexpression of manganese superoxide dismutase attenuates neuronal death in human cells expressing mutant (G37R) Cu/Zn-superoxide dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Animal models of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

High throughput drug screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

An analysis of extended survival in patients with amyotrophic lateral sclerosis treated with riluzole

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. WALS Study Group. Western Amyotrophic Lateral Sclerosis Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

A clinical trial of verapamil in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Prostaglandins stimulate calcium-dependent glutamate release in astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Marked increase in cyclooxygenase-2 in ALS spinal cord: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS riluzole-tocopherol Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

A randomized sequential trial of creatine in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

A clinical trial of creatine in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Tetracycline derivatives and ceftriaxone, a cephalosporin antibiotic, protect neurons against apoptosis induced by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Blood vessels and nerves: common signals, pathways and diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Coenzyme Q10 as a possible treatment for neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Minocycline delays disease onset and mortality in a transgenic model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

Identification of candidate drugs for the treatment of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270005282631

21 January 2018

Identifiers

DOI

10.1177/0091270005282631

1 reference

13 August 2017

1 reference