(Q36316921)

13 August 2017

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title

Drug delivery strategies for cathepsin inhibitors in joint diseases (English)

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13 August 2017

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Dong Wang

1

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13 August 2017

Dieter Brömme

series ordinal

2

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13 August 2017

language of work or name

English

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publication date

1 November 2005

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Expert Opinion on Drug Delivery

13 August 2017

published in

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13 August 2017

volume

2

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13 August 2017

issue

6

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13 August 2017

page(s)

1015-1028

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Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis

13 August 2017

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Therapeutic strategies for rheumatoid arthritis

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Osteoarthritis - an untreatable disease?

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21 January 2018

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Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation

21 January 2018

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Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis

21 January 2018

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Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis.

21 January 2018

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Regulation of collagenase activities of human cathepsins by glycosaminoglycans

21 January 2018

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Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme

21 January 2018

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Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis

21 January 2018

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Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages

21 January 2018

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Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling.

21 January 2018

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The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics

21 January 2018

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Action of rat liver cathepsin L on collagen and other substrates

21 January 2018

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Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix

21 January 2018

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21 January 2018

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Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

21 January 2018

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Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase

21 January 2018

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Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope

21 January 2018

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Cysteine proteinases and matrix metalloproteinases play distinct roles in the subosteoclastic resorption zone.

21 January 2018

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The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation.

21 January 2018

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Dendritic cells: the driving force behind autoimmunity in rheumatoid arthritis?

21 January 2018

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Lysosomal cysteine proteases regulate antigen presentation

21 January 2018

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21 January 2018

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Thiol-dependent cathepsins: pathophysiological implications and recent advances in inhibitor design

21 January 2018

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Protease inhibitors: current status and future prospects

21 January 2018

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Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor

21 January 2018

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Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin

21 January 2018

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Population pharmacokinetics in phase I drug development: a phase I study of PK1 in patients with solid tumours

21 January 2018

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The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study.

21 January 2018

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Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes

21 January 2018

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A comparison of liposomal formulations of doxorubicin with drug administered in free form: changing toxicity profiles

21 January 2018

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Albumin-coupled methotrexate (MTX-HSA) is a new anti-arthritic drug which acts synergistically to MTX.

21 January 2018

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Albumin binding as a general strategy for improving the pharmacokinetics of proteins

21 January 2018

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Clinical pharmacokinetics of leflunomide

21 January 2018

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Acidosis of synovial fluid correlates with synovial fluid leukocytosis

21 January 2018

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A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier

21 January 2018

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Current status of pH-sensitive liposomes in drug delivery

21 January 2018

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Role of the N-terminal peptides of viral envelope proteins in membrane fusion.

21 January 2018

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Application of membrane-active peptides for drug and gene delivery across cellular membranes.

21 January 2018

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Advantages of liposomal delivery systems for anthracyclines

21 January 2018

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21 January 2018

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21 January 2018

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Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages.

21 January 2018

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Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells.

21 January 2018

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pH-Responsive copolymer assemblies for controlled release of doxorubicin

21 January 2018

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HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action

21 January 2018

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Synthesis and characterisation of inulin-azo hydrogels designed for colon targeting.

21 January 2018

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Synthesis and pharmacokinetic profile of a quaternary ammonium derivative of chlorambucil, a potential anticancer drug for the chemotherapy of chondrosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2.6.1015

Synthesis and in vivo biodisposition of [14C]-quaternary ammonium-melphalan conjugate, a potential cartilage-targeted alkylating drug.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2.6.1015

Iodo-bis(quaternary ammonium) salts. Potential cartilage-selective x-ray contrast agents

21 January 2018

1 reference

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Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells

21 January 2018

1 reference

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The role of bone in the treatment of osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2.6.1015

Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2.6.1015

Bone-targeting macromolecular therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2.6.1015

An EP2 receptor-selective prostaglandin E 2 agonist induces bone healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2.6.1015

Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2.6.1015

The dawning era of polymer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2.6.1015

Protease-mediated fragmentation of p-amidobenzyl ethers: a new strategy for the activation of anticancer prodrugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2.6.1015

10.1517/17425247.2.6.1015

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference