(Q36318541)

13 August 2017

1 reference

title

Individualised cancer therapeutics: dream or reality? (English)

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13 August 2017

Neil Senzer

1

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13 August 2017

Yuqiao Shen

series ordinal

2

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13 August 2017

Colin Hill

series ordinal

3

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13 August 2017

John Nemunaitis

series ordinal

4

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13 August 2017

language of work or name

English

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publication date

1 December 2005

1 reference

Expert Opinion on Therapeutic Targets

13 August 2017

published in

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13 August 2017

volume

9

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13 August 2017

issue

6

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13 August 2017

page(s)

1189-1201

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13 August 2017

cites work

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Degeneracy and complexity in biological systems

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Global analysis of the genetic network controlling a bacterial cell cycle

21 January 2018

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Network biology: understanding the cell's functional organization

21 January 2018

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Reconstruction of cellular signalling networks and analysis of their properties

21 January 2018

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Integrating genetic approaches into the discovery of anticancer drugs

21 January 2018

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Lethality and centrality in protein networks

21 January 2018

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An integrated approach for inference and mechanistic modeling for advancing drug development

21 January 2018

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Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks

21 January 2018

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Causal protein-signaling networks derived from multiparameter single-cell data

21 January 2018

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Molecular targets in cancer therapy

21 January 2018

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Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia

21 January 2018

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Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 1.

21 January 2018

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

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Molecular profiling of human cancer

21 January 2018

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An overview of targeted treatments in cancer

21 January 2018

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Targeted therapy for malignant melanoma

21 January 2018

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Gastrointestinal stromal tumors: a paradigm for molecularly targeted therapy

21 January 2018

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Towards molecular diagnosis and targeted therapy of lymphoid malignancies

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Analysing differential gene expression in cancer.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Molecular classification of cutaneous malignant melanoma by gene expression profiling

21 January 2018

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Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

21 January 2018

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Molecular portraits of human breast tumours

21 January 2018

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Systematic variation in gene expression patterns in human cancer cell lines

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Genomic and proteomic technologies for individualisation and improvement of cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Diversity of gene expression in adenocarcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Laser capture microdissection

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

A gene-expression signature as a predictor of survival in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

A multigenic program mediating breast cancer metastasis to bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Proteome research: complementarity and limitations with respect to the RNA and DNA worlds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Tissue microarray assessment of prostate cancer tumor proliferation in African- American and white men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Oncogenic kinase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Proteomics in translational cancer research: toward an integrated approach

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Signaling--2000 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

The large-scale organization of metabolic networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Protein modules and signalling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Proteomics: new perspectives, new biomedical opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Integrated genomic and proteomic analyses of a systematically perturbed metabolic network

21 January 2018

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From the analysis of protein complexes to proteome-wide linkage maps

21 January 2018

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A network of protein-protein interactions in yeast

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

A microarray immunoassay for simultaneous detection of proteins and bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Proteomics to study genes and genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Automatic identification of proteins with a MALDI-quadrupole ion trap mass spectrometer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Analysis of quantitative proteomic data generated via multidimensional protein identification technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Large-scale analysis of the yeast proteome by multidimensional protein identification technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

2D differential in-gel electrophoresis for the identification of esophageal scans cell cancer-specific protein markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Quantitative proteome analysis by solid-phase isotope tagging and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Emerging tandem-mass-spectrometry techniques for the rapid identification of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Protein analysis by mass spectrometry and sequence database searching: tools for cancer research in the post-genomic era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

The yeast nuclear pore complex: composition, architecture, and transport mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Difference gel electrophoresis: a single gel method for detecting changes in protein extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

The microenvironment of the tumour-host interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Akt is a downstream target of NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Proteomic patterns of tumour subsets in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

RNA sequence- and shape-dependent recognition by proteins in the ribonucleoprotein particle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Messenger-RNA-binding proteins and the messages they carry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

New and old roles of the double-stranded RNA-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

The dsRNA binding protein family: critical roles, diverse cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Towards therapeutic applications of engineered zinc finger proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Induction of angiogenesis in a mouse model using engineered transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

RNA interference: a potent tool for gene-specific therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Argonaute2 is the catalytic engine of mammalian RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Challenges for RNAi in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

RNA interference in mammalian cells by chemically-modified RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

RNA interference may be more potent than antisense RNA in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

siRNA agents inhibit oncogene expression and attenuate human tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Specific inhibition of bcr-abl gene expression by small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by e6 siRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

High-Throughput Proteomics Using High-Efficiency Multiple-Capillary Liquid Chromatography with On-Line High-Performance ESI FTICR Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1189

10.1517/14728222.9.6.1189

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference