(Q36318546)

13 August 2017

1 reference

title

Targeting Ubc9 for cancer therapy (English)

1 reference

13 August 2017

Yin-Yuan Mo

1

1 reference

PubMed ID

16300471

13 August 2017

Stergios J Moschos

series ordinal

2

1 reference

PubMed ID

16300471

13 August 2017

language of work or name

English

0 references

publication date

1 December 2005

1 reference

Expert Opinion on Therapeutic Targets

13 August 2017

1 reference

13 August 2017

9

1 reference

13 August 2017

6

1 reference

13 August 2017

1203-1216

1 reference

SUMO--nonclassical ubiquitin

13 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Protein modification by SUMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

SUMO, ubiquitin's mysterious cousin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Nuclear and unclear functions of SUMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Identification of sumoylated proteins by systematic immunoprecipitation of the budding yeast proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Identification of a multifunctional binding site on Ubc9p required for Smt3p conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Involvement of PIAS1 in the sumoylation of tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

The nucleoporin RanBP2 has SUMO1 E3 ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

The polycomb protein Pc2 is a SUMO E3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

A new protease required for cell-cycle progression in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Positive and negative regulation of APP amyloidogenesis by sumoylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Distinct in vivo dynamics of vertebrate SUMO paralogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in the degradation of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Ubch9 conjugates SUMO but not ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Cloning and developmental expression of a nuclear ubiquitin-conjugating enzyme (DmUbc9) that interacts with small heat shock proteins in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

The Drosophila semushi mutation blocks nuclear import of bicoid during embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

RanBP2 associates with Ubc9p and a modified form of RanGAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Mechanisms underlying ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

The binding interface between an E2 (UBC9) and a ubiquitin homologue (UBL1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Identification of a substrate recognition site on Ubc9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Sumoylation silences the plasma membrane leak K+ channel K2P1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Yeast two-hybrid system identifies the ubiquitin-conjugating enzyme mUbc9 as a potential partner of mouse Dac

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Ubc9 interacts with chicken ovalbumin upstream promoter-transcription factor I and represses receptor-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Nuclear speckles: a model for nuclear organelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

SUMO-1 modification of the Wilms' tumor suppressor WT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

SUMO: a regulator of gene expression and genome integrity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Ikaros SUMOylation: switching out of repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

SUMO promotes HDAC-mediated transcriptional repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Histone sumoylation is associated with transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

SUMO modification of Huntingtin and Huntington's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Ubc9 interacts with a nuclear localization signal and mediates nuclear localization of the paired-like homeobox protein Vsx-1 independent of SUMO-1 modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

FHL2, UBC9, and PIAS1 are novel estrogen receptor alpha-interacting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Ubc9-induced inhibition of diadenosine triphosphate hydrolase activity of the putative tumor suppressor protein Fhit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

The Drosophila UBC9 homologue lesswright mediates the disjunction of homologues in meiosis I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Functional analysis and intracellular localization of p53 modified by SUMO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Identification of Xenopus heat shock transcription factor-2: conserved role of sumoylation in regulating deoxyribonucleic acid-binding activity of heat shock transcription factor-2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

A mechanism for inhibiting the SUMO pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

RNA interference: the new somatic cell genetics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

A genome-wide analysis of sumoylation-related biological processes and functions in human nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1203

p300 Transcriptional Repression Is Mediated by SUMO Modification

21 January 2018

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S1097-2765(03)00141-2

Identifiers

DOI

10.1517/14728222.9.6.1203

1 reference

13 August 2017

1 reference

PubMed ID

16300471