(Q53861588)

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Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage.

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10 January 2020

Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15817450%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Robert J.D. Reid

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15817450%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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Hervé R Jacquiau

1

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10 January 2020

Robert C A M van Waardenburg

2

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10 January 2020

Michael H Woo

4

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10 January 2020

Hong Guo

5

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10 January 2020

Erica S Johnson

6

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10 January 2020

Mary-Ann Bjornsti

7

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10 January 2020

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6 April 2005

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10 January 2020

Journal of Biological Chemistry

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10 January 2020

280

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10 January 2020

25

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10 January 2020

23566-23575

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10 January 2020

DNA topoisomerases: structure, function, and mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases

1 reference

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21 January 2018

Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs

1 reference

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21 January 2018

Cellular roles of dna topoisomerases: a molecular perspective

1 reference

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21 January 2018

Tumor cell death induced by topoisomerase-targeting drugs.

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21 January 2018

Repair of and checkpoint response to topoisomerase I-mediated DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Clinical use of topoisomerase I inhibitors in anticancer treatment

1 reference

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21 January 2018

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

1 reference

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21 January 2018

S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

1 reference

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21 January 2018

Genes required for ionizing radiation resistance in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage.

1 reference

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21 January 2018

The Mechanism of Mus81-Mms4 Cleavage Site Selection Distinguishes It from the Homologous Endonuclease Rad1-Rad10

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Protein modification by SUMO

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

SUMO: ligases, isopeptidases and nuclear pores

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase I.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Global analysis of protein sumoylation in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

1 reference

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21 January 2018

Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Two nuclear mutations that block mitochondrial protein import in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

A functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500947200

21 January 2018

Identification of a multifunctional binding site on Ubc9p required for Smt3p conjugation

1 reference

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21 January 2018

SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I

1 reference

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21 January 2018

Residues within the N-terminal Domain of Human Topoisomerase I Play a Direct Role in Relaxation*

1 reference

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21 January 2018

A Proteome-wide Approach Identifies Sumoylated Substrate Proteins in Yeast

1 reference

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21 January 2018

A Proteomic Strategy for Gaining Insights into Protein Sumoylation in Yeast

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M500947200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15817450%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15817450%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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