(Q38293789)

1 September 2017

Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin (English)

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1 September 2017

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Michael H Woo

1

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1 September 2017

John R Vance

2

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1 September 2017

Ana R Otero Marcos

3

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1 September 2017

Christian Bailly

4

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1 September 2017

Mary-Ann Bjornsti

5

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1 September 2017

language of work or name

English

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publication date

3 December 2001

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Journal of Biological Chemistry

1 September 2017

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1 September 2017

277

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1 September 2017

6

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1 September 2017

3813-3822

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Vascular factors in cognitive impairment--where are we now?

1 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

A model for the mechanism of human topoisomerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110484200

The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Topoisomerase I poisons and suppressors as anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Translating the knowledge of molecular alterations that occur during colon carcinogenesis into clinically relevant solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Structural insights into the function of type IB topoisomerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Recognition of specific sequences in DNA by a topoisomerase I inhibitor derived from the antitumor drug rebeccamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

The Camptothecin-Resistant Topoisomerase I Mutant F361S Is Cross-Resistant to Antitumor Rebeccamycin Derivatives. A Model for Topoisomerase I Inhibition by Indolocarbazoles†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Increased camptothecin toxicity induced in mammalian cells expressing Saccharomyces cerevisiae DNA topoisomerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

Indolocarbazole poisons of human topoisomerase I: regioisomeric analogues of ED-110

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110484200

21 January 2018

Identifiers

DOI

10.1074/JBC.M110484200

1 reference

1 September 2017

1 reference