(Q45110862)

9 December 2017

title

Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I. (English)

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9 December 2017

4

Alex B Burgin

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9 December 2017

William C Colley

1

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9 December 2017

Marie van der Merwe

series ordinal

2

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9 December 2017

John R Vance

series ordinal

3

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9 December 2017

Mary-Ann Bjornsti

series ordinal

5

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9 December 2017

language of work or name

English

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publication date

15 October 2004

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Journal of Biological Chemistry

9 December 2017

published in

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9 December 2017

volume

279

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9 December 2017

issue

52

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9 December 2017

page(s)

54069-54078

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DNA topoisomerases: structure, function, and mechanism

9 December 2017

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The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons.

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Validation of a novel assay for checkpoint responses: characterization of camptothecin derivatives in Saccharomyces cerevisiae

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CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage.

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The Mechanism of Mus81-Mms4 Cleavage Site Selection Distinguishes It from the Homologous Endonuclease Rad1-Rad10

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A model for the mechanism of human topoisomerase I

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Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.

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Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex

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Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.

21 January 2018

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Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin

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The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

21 January 2018

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SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I

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A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons

21 January 2018

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A novel suicide substrate for DNA topoisomerases and site-specific recombinases

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DNA topoisomerase-targeting antitumor drugs can be studied in yeast

21 January 2018

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Mechanisms of camptothecin resistance by human topoisomerase I mutations

21 January 2018

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Catalytic mechanism of DNA topoisomerase IB.

21 January 2018

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8-Oxoguanine rearranges the active site of human topoisomerase I

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M409764200

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9 December 2017

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