(Q33712882)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

author name string

Michael H Woo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Hong Guo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Luca Pattarello

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Piero Benedetti

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Mary-Ann Bjornsti

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

language of work or name

English

0 references

publication date

29 October 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

20 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

volume

100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

issue

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

page(s)

13767-13772

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

DNA relaxation by human topoisomerase I occurs in the closed clamp conformation of the protein

20 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Non-reciprocal regulation of the redox state of the glutathione-glutaredoxin and thioredoxin systems

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Cancer therapeutics in yeast

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Cellular roles of dna topoisomerases: a molecular perspective

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

DNA topoisomerases: structure, function, and mechanism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Tumor cell death induced by topoisomerase-targeting drugs.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Molecular and biological determinants of the cytotoxic actions of camptothecins. Perspective for the development of new topoisomerase I inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Mechanism of action of camptothecin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Clinical use of topoisomerase I inhibitors in anticancer treatment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

A model for the mechanism of human topoisomerase I

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Intradimerically tethered DNA topoisomerase II is catalytically active in DNA transport

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Supercoiling of intracellular DNA can occur in eukaryotic cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=283496

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

21 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235886100

Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235886100

Vascular factors in cognitive impairment--where are we now?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235886100

Enzymes that push DNA around

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235886100

Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235886100

Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235886100

Increased camptothecin toxicity induced in mammalian cells expressing Saccharomyces cerevisiae DNA topoisomerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235886100

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235886100

Reconstitution of enzymatic activity by the association of the cap and catalytic domains of human topoisomerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235886100

Translating the knowledge of molecular alterations that occur during colon carcinogenesis into clinically relevant solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2235886100

Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14585933

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.2235886100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585933%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference