(Q36318564)

13 August 2017

1 reference

title

The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis (English)

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13 August 2017

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1

Hirokazu Tamamura

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13 August 2017

Nobutaka Fujii

2

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PubMed ID

16300475

13 August 2017

language of work or name

English

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publication date

1 December 2005

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Expert Opinion on Therapeutic Targets

13 August 2017

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13 August 2017

9

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13 August 2017

6

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13 August 2017

1267-1282

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Molecular cloning and structure of a pre-B-cell growth-stimulating factor

13 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Expression of functional chemokine receptors CXCR3 and CXCR4 on human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

CXCR4/CXCL12 expression and signalling in kidney cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Identification of a major co-receptor for primary isolates of HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

The significance of cancer cell expression of the chemokine receptor CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

HIV entry and its inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

A novel anti-HIV synthetic peptide, T-22 ([Tyr5,12,Lys7]-polyphemusin II)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Marked increase in anti-HIV activity, as well as inhibitory activity against HIV entry mediated by CXCR4, linked to enhancement of the binding ability of tachyplesin analogs to CXCR4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Biological and genetic characterization of a human immunodeficiency virus strain resistant to CXCR4 antagonist T134.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Rediscovering an endothelin antagonist (BQ-123): a self-deconvoluting cyclic pentapeptide library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Reduction of Peptide Character of HIV Protease Inhibitors That Exhibit Nanomolar Potency against Multidrug Resistant HIV-1 Strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Non-peptidic chemokine receptors antagonists as emerging anti-HIV agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

New bicyclam-GalCer analogue conjugates: synthesis and in vitro anti-HIV activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Anti-HIV activity of a novel aminoglycoside-arginine conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

Small molecule antagonists of chemokine receptors as emerging anti-HIV agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1267

10.1517/14728222.9.6.1267

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16300475