(Q36325596)

13 August 2017

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title

The expanding role of BDNF: a therapeutic target for Alzheimer's disease? (English)

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13 August 2017

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Fumagalli F

1

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13 August 2017

Racagni G

series ordinal

2

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13 August 2017

Riva MA

series ordinal

3

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13 August 2017

1 January 2006

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The Pharmacogenomics Journal

13 August 2017

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13 August 2017

6

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13 August 2017

1

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13 August 2017

8-15

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https://scigraph.springernature.com/pub.10.1038/sj.tpj.6500337

13 August 2017

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cites work

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Essential role for TrkB receptors in hippocampus-mediated learning

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BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

21 January 2018

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Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease.

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Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease.

21 January 2018

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Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease.

21 January 2018

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An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease.

21 January 2018

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A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex.

21 January 2018

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The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

21 January 2018

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A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease.

21 January 2018

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Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease.

21 January 2018

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Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy.

21 January 2018

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Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism

21 January 2018

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Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset

21 January 2018

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Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease

21 January 2018

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Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer's disease

21 January 2018

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Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's disease.

21 January 2018

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Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression

21 January 2018

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Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms.

21 January 2018

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Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus

21 January 2018

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Corticostriatal brain-derived neurotrophic factor dysregulation in adult rats following prenatal stress.

21 January 2018

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Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling

21 January 2018

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Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor.

21 January 2018

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Grafting of encapsulated BDNF-producing fibroblasts into the injured spinal cord without immune suppression in adult rats

21 January 2018

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The regrowth of axons within tissue defects in the CNS is promoted by implanted hydrogel matrices that contain BDNF and CNTF producing fibroblasts

21 January 2018

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Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice

21 January 2018

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Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope

21 January 2018

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Combination therapy in Alzheimer's disease: a review of current evidence

21 January 2018

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The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain

21 January 2018

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Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator.

21 January 2018

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An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study.

21 January 2018

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Chronic elevation of brain-derived neurotrophic factor by ampakines

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro

21 January 2018

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AMPA receptor modulators as cognitive enhancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Enhancement by an ampakine of memory encoding in humans.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans.

21 January 2018

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Estrogens and neuroprotection

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Estradiol prevents amyloid-beta peptide-induced cell death in a cholinergic cell line via modulation of a classical estrogen receptor.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Pharmacotherapeutic approaches to the prevention of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Estrogen replacement therapy: effects on the cognitive functioning and clinical course of women with Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Impact of estrogen therapy on Alzheimer's disease: a fork in the road?

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Estrogen and brain: synthesis, function and diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Direct, complex effects of estrogens on basal forebrain cholinergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Region- and peptide-specific regulation of the neurotrophins by estrogen.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Cannabinoid receptor activation and elevated cyclic AMP reduce glutamate neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

SGS742: the first GABA(B) receptor antagonist in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

beta-amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Lithium neuroprotection: molecular mechanisms and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

APP processing and synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Physical activity and risk of cognitive impairment and dementia in elderly persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Dietary factors and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Vitamin E and cognitive decline in older persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Dietary intake of antioxidants and risk of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Immunotherapy for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Region-Specific Neurotrophin Imbalances in Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

Neurotrophic factors in Alzheimer's and Parkinson's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

The postnatal environment can counteract prenatal effects on cognitive ability, cell proliferation, and synaptic protein expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

The role of the extracellular signal-regulated kinase signaling pathway in mood modulation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

Oxidative alterations in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500337

7 January 2021

Identifiers

DOI

10.1038/SJ.TPJ.6500337

1 reference

Dimensions Publication ID

13 August 2017

0 references

1 reference