(Q36339227)

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Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth

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scholarly article

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Europe PubMed Central

PMC publication ID

13 August 2017

Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth (English)

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Europe PubMed Central

PMC publication ID

13 August 2017

mitochondrial fission

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Michael P. Lisanti

12

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Michael P Lisanti

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Europe PubMed Central

13 August 2017

PMC publication ID

Federica Sotgia

11

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Federica Sotgia

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Europe PubMed Central

13 August 2017

PMC publication ID

Diana Whitaker-Menezes

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Diana Whitaker-Menezes

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Europe PubMed Central

13 August 2017

PMC publication ID

6

object named as

Teresa A Zimmers

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Europe PubMed Central

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13 August 2017

Richard Pestell

4

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Richard G Pestell

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Europe PubMed Central

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13 August 2017

Ubaldo E Martinez-Outschoorn

10

object named as

Ubaldo E Martinez-Outschoorn

1 reference

Europe PubMed Central

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13 August 2017

5

object named as

Anthony Howell

1 reference

Europe PubMed Central

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13 August 2017

1

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Carmela Guido

1 reference

Europe PubMed Central

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13 August 2017

8

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Saveria Aquila

1 reference

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13 August 2017

author name string

Zhao Lin

3

1 reference

Europe PubMed Central

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13 August 2017

Mathew C Casimiro

7

1 reference

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13 August 2017

Sebastiano Ando'

9

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Europe PubMed Central

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13 August 2017

language of work or name

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publication date

1 August 2012

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Europe PubMed Central

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13 August 2017

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Europe PubMed Central

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13 August 2017

3

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Europe PubMed Central

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13 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

798-810

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

1 reference

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CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.

1 reference

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30 September 2017

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production

1 reference

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Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue

1 reference

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Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers

1 reference

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Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

1 reference

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Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism

1 reference

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Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue

1 reference

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Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection

1 reference

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Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms

1 reference

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30 September 2017

Mitophagy: a complex mechanism of mitochondrial removal

1 reference

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Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

1 reference

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Energy transfer in "parasitic" cancer metabolism: mitochondria are the powerhouse and Achilles' heel of tumor cells

1 reference

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Together we are stronger: fusion protects mitochondria from autophagosomal degradation

1 reference

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30 September 2017

Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis

1 reference

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30 September 2017

Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment

1 reference

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30 September 2017

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors

1 reference

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30 September 2017

Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells

1 reference

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30 September 2017

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".

1 reference

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30 September 2017

Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator

1 reference

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30 September 2017

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3478457

30 September 2017

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3478457

30 September 2017

Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3478457

30 September 2017

Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3478457

30 September 2017

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3478457

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The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox

1 reference

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Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

1 reference

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HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3478457

30 September 2017

The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

1 reference

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Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment

1 reference

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Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

1 reference

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30 September 2017

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

1 reference

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Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling

1 reference

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Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors

1 reference

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Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

1 reference

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Mitochondrial energetics and therapeutics

1 reference

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Mitochondria, bioenergetics, and the epigenome in eukaryotic and human evolution

1 reference

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The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

1 reference

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

1 reference

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Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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A delicate balance: TGF-beta and the tumor microenvironment

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The expanding phenotype of mitochondrial myopathy

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

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Cancer metabolism: facts, fantasy, and fiction

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On respiratory impairment in cancer cells

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On the Origin of Cancer Cells

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Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

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Mitochondrial biogenesis drives tumor cell proliferation

1 reference

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A history of mitochondrial diseases.

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Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts.

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Why do tumors metastasize?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22878233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer associated fibroblasts stimulated by transforming growth factor beta1 (TGF-beta 1) increase invasion rate of tumor cells: a population study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22878233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial stress signals revise an old aging theory

1 reference

https://pubmed.ncbi.nlm.nih.gov/22878233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22878233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Power surge: supporting cells "fuel" cancer cell mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/22878233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.574

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

0 references

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