(Q36347766)

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Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes.

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12 February 2020

Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22930750%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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Laura Mangiavini

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12 February 2020

Johanna Myllyharju

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Johanna Myllyharju

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12 February 2020

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Ellinoora Aro

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12 February 2020

Richa Khatri

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12 February 2020

Rita Gerard-O'Riley

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12 February 2020

Ernestina Schipani

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12 February 2020

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publication date

28 August 2012

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12 February 2020

Journal of Biological Chemistry

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12 February 2020

287

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12 February 2020

44

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12 February 2020

37134-37144

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22930750%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Inhibition of hypoxia-inducible factor-targeting prolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

HIF prolyl 4-hydroxylases and their potential as drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Extracellular matrix genes as hypoxia-inducible targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Acute postnatal ablation of Hif-2alpha results in anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Hypoxia-inducible factors: central regulators of the tumor phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Integrins in growth plate cartilage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Collagens, modifying enzymes and their mutations in humans, flies and worms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Oxygen tension regulates the expression of a group of procollagen hydroxylases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Identification of a novel proline-rich peptide-binding domain in prolyl 4-hydroxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Chondrocyte-matrix attachment complexes mediate survival and differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

Characterization of the human prolyl 4-hydroxylase tetramer and its multifunctional protein disulfide-isomerase subunit synthesized in a baculovirus expression system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

30 September 2017

HIF-1 and HIF-2: working alone or together in hypoxia?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

29 June 2018

VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

22 September 2018

Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

22 September 2018

Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

22 September 2018

Hypoxia, HIFs and bone development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

22 September 2018

Localization of erythropoietin in and around growing cartilage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

22 September 2018

Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

22 September 2018

Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

22 September 2018

HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481313

22 September 2018

Modified procedure for the assay of H-3-or C-14-labeled hydroxyproline

1 reference

https://pubmed.ncbi.nlm.nih.gov/22930750

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

10 Posttranslational enzymes in the biosynthesis of collagen: Intracellular enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22930750

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel type II prolyl 4-hydroxylase is the main enzyme form in chondrocytes and capillary endothelial cells, whereas the type I enzyme predominates in most cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22930750

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 2alpha is essential for hypoxic induction of the human articular chondrocyte phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/22930750

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor: roles in development, physiology, and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22930750

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III

1 reference

https://pubmed.ncbi.nlm.nih.gov/22930750

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22930750

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.352872

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22930750%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22930750%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22930750%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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