(Q36347988)

13 August 2017

Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL. (English)

1 reference

13 August 2017

Renate Kirschner-Schwabe

object named as

Renate Kirschner-Schwabe

4

0 references

Arend von Stackelberg

25

object named as

Arend von Stackelberg

1 reference

13 August 2017

Benshang Li

1

1 reference

13 August 2017

Hui Li

2

1 reference

13 August 2017

Yun Bai

3

1 reference

13 August 2017

Jun J Yang

5

1 reference

13 August 2017

Yao Chen

6

1 reference

13 August 2017

Gang Lu

7

1 reference

13 August 2017

Gannie Tzoneva

8

1 reference

13 August 2017

Xiaotu Ma

9

1 reference

13 August 2017

Tongmin Wu

10

1 reference

13 August 2017

Wenjing Li

11

1 reference

13 August 2017

Haisong Lu

12

1 reference

13 August 2017

Lixia Ding

13

1 reference

13 August 2017

Huanhuan Liang

14

1 reference

13 August 2017

Xiaohang Huang

15

1 reference

13 August 2017

Minjun Yang

16

1 reference

13 August 2017

Lei Jin

17

1 reference

13 August 2017

Hui Kang

18

1 reference

13 August 2017

Shuting Chen

19

1 reference

13 August 2017

Alicia Du

20

1 reference

13 August 2017

Shuhong Shen

21

1 reference

13 August 2017

Jianping Ding

22

1 reference

13 August 2017

Hongzhuan Chen

23

1 reference

13 August 2017

Jing Chen

24

1 reference

13 August 2017

Longjun Gu

26

1 reference

13 August 2017

Jinghui Zhang

27

1 reference

13 August 2017

Adolfo Ferrando

28

1 reference

13 August 2017

Jingyan Tang

29

1 reference

13 August 2017

Shengyue Wang

30

1 reference

13 August 2017

Bin-Bing S Zhou

31

1 reference

13 August 2017

language of work or name

English

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publication date

11 May 2015

1 reference

13 August 2017

1 reference

13 August 2017

21

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13 August 2017

6

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13 August 2017

563-571

1 reference

https://scigraph.springernature.com/pub.10.1038/nm.3840

13 August 2017

0 references

cites work

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

From feedback inhibition to allostery: the enduring example of aspartate transcarbamoylase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

ALL-REZ BFM--the consecutive trials for children with relapsed acute lymphoblastic leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Metabolic enzyme IMPDH is also a transcription factor regulated by cellular state

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

A novel retinoblastoma therapy from genomic and epigenetic analyses

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

50th anniversary of the word "allosteric".

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Nucleotide deficiency promotes genomic instability in early stages of cancer development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Biology, risk stratification, and therapy of pediatric acute leukemias: an update

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

PRPS1 mutations: four distinct syndromes and potential treatment.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

The molecular determinants of de novo nucleotide biosynthesis in cancer cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Expression, purification, crystallization and preliminary X-ray diffraction analysis of human phosphoribosyl pyrophosphate synthetase 1 (PRS1)

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Inhibitors of de novo nucleotide biosynthesis as drugs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

New agents in cancer clinical trials

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

The DNA damage response: putting checkpoints in perspective

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Structural basis for the function of Bacillus subtilis phosphoribosyl-pyrophosphate synthetase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

The genetic and functional basis of purine nucleotide feedback-resistant phosphoribosylpyrophosphate synthetase superactivity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Human phosphoribosylpyrophosphate synthetase. Distribution, purification, and properties

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Regulation of purine biosynthesis and turnover

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Mutant feedback-resistant phosphoribosylpyrophosphate synthetase associated with purine overproduction and gout. Phosphoribosylpyrophosphate and purine metabolism in cultured fibroblasts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Comparative investigation of free nucleotides in two neuroblastoma clonal cell lines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Recent advances in the biology and treatment of childhood acute lymphoblastic leukemia.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Phosphoribosylpyrophosphate synthetase superactivity and recurrent infections is caused by a p.Val142Leu mutation in PRS-I.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratification and intensified short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Clinical outcome of children with newly diagnosed acute lymphoblastic leukemia treated in a single center in Shanghai, China

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

HPLC determination of thiopurine nucleosides and nucleotides in vivo in lymphoblasts following mercaptopurine therapy

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Regulation of purine synthesis de novo in human fibroblasts by purine nucleotides and phosphoribosylpyrophosphate

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670083

Thiopurine biology and pharmacology

22 September 2018

1 reference

12 December 2020

[Evaluation on protocol SCMS-ALL-2005 for childhood B lineage acute lymphoblastic leukemia]

1 reference

12 December 2020

Doxorubicin or daunorubicin given upfront in a therapeutic window are equally effective in children with newly diagnosed acute lymphoblastic leukemia. A randomized comparison in trial CoALL 07-03

1 reference

12 December 2020

Overexpression, purification, and characterization of recombinant human 5-phosphoribosyl-1-pyrophosphate synthetase isozymes I and II

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.3840

1 reference

Dimensions Publication ID

13 August 2017

0 references

1 reference

13 August 2017

1 reference