(Q36368300)

13 August 2017

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62. (English)

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13 August 2017

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2

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9 June 2020

Miguel A Pineda

4

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9 June 2020

Margaret Harnett

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9 June 2020

author name string

Felicity E Lumb

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9 June 2020

Kara S Bell

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9 June 2020

Marlene Corbet

5

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9 June 2020

Colin J Suckling

6

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9 June 2020

William Harnett

8

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9 June 2020

language of work or name

English

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publication date

10 May 2017

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13 August 2017

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9 June 2020

volume

7

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9 June 2020

issue

1

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9 June 2020

page(s)

1704

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Creative Commons Attribution 4.0 International

9 June 2020

copyright license

start time

10 May 2017

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/s41598-017-01651-1

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cites work

The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ.

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30 September 2017

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Adoptive transfer of helminth antigen-pulsed dendritic cells protects against the development of experimental colitis in mice.

30 September 2017

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Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release.

30 September 2017

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Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

30 September 2017

1 reference

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Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

30 September 2017

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ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae.

30 September 2017

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Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis.

30 September 2017

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Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.

30 September 2017

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The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype

30 September 2017

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The role of inflammasome-derived IL-1 in driving IL-17 responses

30 September 2017

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Helminth antigens enable CpG-activated dendritic cells to inhibit the symptoms of collagen-induced arthritis through Foxp3+ regulatory T cells

30 September 2017

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Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures

30 September 2017

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Pathogen recognition by the innate immune system

30 September 2017

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

30 September 2017

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Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses

30 September 2017

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The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function

30 September 2017

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Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function

30 September 2017

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Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites

30 September 2017

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Regulatory T cells and infection: a dangerous necessity

30 September 2017

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

30 September 2017

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A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62.

30 September 2017

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Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-kappa B.

30 September 2017

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An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

30 September 2017

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Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5431997

ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the joints

21 September 2018

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Application of dendritic cells stimulated with Trichinella spiralis excretory-secretory antigens alleviates experimental autoimmune encephalomyelitis.

21 September 2018

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Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo.

21 September 2018

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Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5431997

ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo.

21 September 2018

1 reference

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Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism

21 September 2018

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Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses

21 September 2018

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Dendritic cell survival and maturation are regulated by different signaling pathways.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5431997

The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-017-01651-1

CD8- dendritic cell activation status plays an integral role in influencing Th2 response development

21 January 2018

1 reference

12 December 2020

A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells

1 reference

12 December 2020

Excretory-secretory products (ESP) from Fasciola hepatica induce tolerogenic properties in myeloid dendritic cells

1 reference

12 December 2020

Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62

1 reference

12 December 2020

Selective inhibition of NF-?B in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization

1 reference

12 December 2020

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites

1 reference

12 December 2020

10.1038/S41598-017-01651-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28490801%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

9 June 2020

0 references

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9 June 2020

PubMed publication ID

28490801

1 reference