(Q36385749)

13 August 2017

A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone (English)

1 reference

Mycobacterium tuberculosis

13 August 2017

0 references

13

Brigitte Gicquel

0 references

Mary Jackson

object named as

Mary Jackson

19

0 references

Jana Korduláková

object named as

Jana Korduláková

2

0 references

Mamadou Daffé

14

object named as

Mamadou Daffé

1 reference

13 August 2017

Juan M Belardinelli

5

0 references

author name string

Anna E Grzegorzewicz

1

1 reference

13 August 2017

Victoria Jones

3

1 reference

13 August 2017

Sarah E M Born

4

1 reference

13 August 2017

Adrien Vaquié

6

1 reference

13 August 2017

Vijay A K B Gundi

7

1 reference

13 August 2017

Jan Madacki

8

1 reference

13 August 2017

Nawel Slama

9

1 reference

13 August 2017

Françoise Laval

10

1 reference

13 August 2017

Julien Vaubourgeix

11

1 reference

13 August 2017

Rebecca M Crew

12

1 reference

13 August 2017

Hector R Morbidoni

15

1 reference

13 August 2017

Patrick J Brennan

16

1 reference

13 August 2017

Annaik Quémard

17

1 reference

13 August 2017

Michael R McNeil

18

1 reference

13 August 2017

language of work or name

English

0 references

publication date

21 September 2012

1 reference

Journal of Biological Chemistry

13 August 2017

8

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

13 August 2017

287

1 reference

13 August 2017

46

1 reference

13 August 2017

38434-38441

1 reference

Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

The structure-activity relationship of urea derivatives as anti-tuberculosis agents

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Protein-protein interactions within the Fatty Acid Synthase-II system of Mycobacterium tuberculosis are essential for mycobacterial viability

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Mycolic acids: structure, biosynthesis and physiological functions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Pharmacology and Toxicology of Isoxyl

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Clinical Experience with Thiocarlide (Isoxyl)

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Effects of Ethionamide and Isoxyl on Mycolic Acid Synthesis in Mycobacterium tuberculosis bcg

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493888

Isoniazid’s Bactericidal Activity Ceases because of the Emergence of Resistance, Not Depletion ofMycobacterium tuberculosisin the Log Phase of Growth

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.400994

Mutations in the essential FAS II β-hydroxyacyl ACP dehydratase complex confer resistance to thiacetazone in Mycobacterium tuberculosis and Mycobacterium kansasii

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23002234

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[Monotherapy with isoxyl-DAT in cases of tuberculosis under hospital care]

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23002234

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.400994

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

23002234

1 reference